DMPK (Q09013) - Overview - Molecular Target Synopsis
DMPK, Myotonin-protein kinase
Enzyme Classification 184.108.40.206
Also Known as DMPK_HUMAN, DMPK, DM1PK, MDPK
Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. Homodimer; homodimerization stimulates the kinase activity. Interacts with HSPB2; may enhance DMPK kinase activity. Interacts with PLN; phosphorylates PLN. May interact with RAC1; may regulate DMPK kinase activity. Interacts with LMNA; may regulate nuclear envelope stability.
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UniProt: DMPK is active in the following subcellular-locations: cell membrane, cytoplasm, cytosol, endoplasmic reticulum membrane, mitochondrion membrane, mitochondrion outer membrane, nucleus outer membrane, sarcoplasmic reticulum membrane.
GO terms: DMPK is active in the following subcellular-locations: cytosol, endoplasmic reticulum membrane, integral component of mitochondrial outer membrane, nuclear membrane, nuclear outer membrane, plasma membrane, sarcoplasmic reticulum membrane.