Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NSUN2 (Q08J23) - Overview - Molecular Target Synopsis

Protein


NSUN2, tRNA (cytosine(34)-C(5))-methyltransferase
Enzyme Classification 2.1.1.203
UniProt Q08J23

Also Known as NSUN2_HUMAN, NSUN2, SAKI, TRM4

RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. Interacts with NPM1 and NCL during interphase; interaction is disrupted following phosphorylation at Ser-139.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NSUN2 is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleolus, nucleus, spindle.
GO terms: NSUN2 is active in the following subcellular-locations: chromatoid body, cytoplasm, nucleolus, nucleoplasm, nucleus, spindle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NSUN2 has gain in 29 cell-lines, loss in 1 cell-lines and no signal in 975 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: K_562, 786_0, DU_145

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SiHa, NCI-H2009, NCI-H1703

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, HSMM

(see details)