NSUN2 (Q08J23) - Overview - Molecular Target Synopsis
NSUN2, tRNA (cytosine(34)-C(5))-methyltransferase
Enzyme Classification 220.127.116.11
Also Known as NSUN2_HUMAN, NSUN2, SAKI, TRM4
RNA methyltransferase that methylates tRNAs, and possibly RNA polymerase III transcripts. Methylates cytosine to 5-methylcytosine (m5C) at positions 34 and 48 of intron-containing tRNA(Leu)(CAA) precursors, and at positions 48, 49 and 50 of tRNA(Gly)(GCC) precursors. May act downstream of Myc to regulate epidermal cell growth and proliferation. Required for proper spindle assembly and chromosome segregation, independently of its methyltransferase activity. Interacts with NPM1 and NCL during interphase; interaction is disrupted following phosphorylation at Ser-139.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: NSUN2 is active in the following subcellular-locations: cytoplasm, cytoskeleton, nucleolus, nucleus, spindle.
GO terms: NSUN2 is active in the following subcellular-locations: chromatoid body, cytoplasm, nucleolus, nucleoplasm, nucleus, spindle.