Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSM2A (Q08AH3) - Overview - Molecular Target Synopsis

Protein


ACSM2A, Acyl-coenzyme A synthetase ACSM2A, mitochondrial
Enzyme Classification 6.2.1.2
UniProt Q08AH3

Also Known as ACS2A_HUMAN, ACSM2A, ACSM2, MACS2

Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro). Monomer.

2WD9
CRYSTAL STRUCTURE OF HUMAN ACYL-COA SYNTHETASE MEDIUM-CHAIN FAMILY MEMBER 2A (L64P MUTATION) IN COMPLEX WITH IBUPROFEN
RCSB/PDB
Inspect Structure
See all 3D Structures for ACSM2A

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSM2A is active in the following subcellular-locations: mitochondrion matrix.
GO terms: ACSM2A is active in the following subcellular-locations: mitochondrial matrix, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSM2A has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, KM12, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ACSM2A there are:
7 structures (13 chains) solved
6 are solved in complex with at least one small molecule ligand
3 are solved with an approved drug

ACSM2A is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (2VZE_A, 2VZE_B, 2VZE_C, 3EQ6_A, 3EQ6_B),
IBP/DEXIBUPROFEN (2WD9_A, 2WD9_B, 2WD9_C).

(see details)
Molecular Target 3D Synopsis