Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SPIRE1 (Q08AE8) - Overview - Molecular Target Synopsis

Protein


SPIRE1, Protein spire homolog 1
UniProt Q08AE8

Also Known as SPIR1_HUMAN, SPIRE1, KIAA1135, SPIR1

Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Interacts with FMN2.

3RBW
CRYSTAL STRUCTURE OF SPIRE KIND DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for SPIRE1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SPIRE1 is active in the following subcellular-locations: cell membrane, cytoplasm, cytoplasmic vesicle membrane, cytoskeleton, perinuclear region.
GO terms: SPIRE1 is active in the following subcellular-locations: cell cortex, cytoplasmic vesicle membrane, cytoskeleton, cytosol, nucleoplasm, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SPIRE1 has gain in 4 cell-lines, loss in 4 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H226, SK_MEL_5, MCF7

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, SUM 1315M02, RERF-LC-KJ

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, SK-N-SH

(see details)

3D Structures


For SPIRE1 there are:
4 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis