SPIRE1 (Q08AE8) - Overview - Molecular Target Synopsis
SPIRE1, Protein spire homolog 1
Also Known as SPIR1_HUMAN, SPIRE1, KIAA1135, SPIR1
Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament (PubMed:11747823, PubMed:21620703). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (PubMed:11747823). Required for asymmetric spindle positioning and asymmetric cell division during meiosis (PubMed:21620703). Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis (PubMed:21620703). Also acts in the nucleus: together with FMN2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:26287480). Interacts with FMN2.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|458||ENSG00000134278||ENST00000440472, ENST00000383356||ENSP00000404752, ENSP00000372847||Q08AE8-4|
UniProt: SPIRE1 is active in the following subcellular-locations: cell membrane, cytoplasm, cytoplasmic vesicle membrane, cytoskeleton, perinuclear region.
GO terms: SPIRE1 is active in the following subcellular-locations: cell cortex, cytoplasmic vesicle membrane, cytoskeleton, cytosol, nucleoplasm, perinuclear region of cytoplasm, plasma membrane.