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Mitf (Q08874) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 07/05/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 07/05/2019)


Chains assessed9
Chains with at least one site assessed as druggable using the strict criteria0
Chains with at least one site assessed as druggable using the relaxed criteria1


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4ATK_A Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 61.1 22 No No
2 empty 2.24 63.4 18.2 No No
3 empty 2.27 67.1 14.8 No No
4 empty 2.57 57.8 10.6 No No
5 empty 2.12 54.2 10.4 No No
6 empty 1.83 57.4 10.2 No No
7 empty 2.75 68.5 10.3 No No
8 empty 3.05 57.7 7.4 No No
9 empty 2.72 51.5 8.1 No No
10 empty 3.09 55 8 No No
6FX5_A Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 62.6 15 No No
2 empty 1.89 60.3 20.4 No No
3 empty 1.76 52.3 15.7 No No
4 empty 3.03 67.6 10.3 No No
5 empty 1.52 66.8 9.7 No No
6 empty 2.36 55.3 12.4 No No
7 empty 2.73 54.2 12.8 No No
8 empty 2.8 49.7 8.5 No No
9 empty 2.64 57.7 6 No No
10 empty 2.42 66.7 9.7 No No
4ATH_A Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 58.9 19.2 No No
2 empty 2.13 67.2 14.3 No No
3 empty 2.84 53.1 19.5 No No
4 empty 1.9 53.2 13.4 No No
5 empty 2.62 53.8 9.5 No No
6 empty 3.16 59.6 8.2 No No
7 empty 2.76 56 10.2 No No
8 empty 2.98 58.4 10.7 No No
9 empty 1.4 80.5 6.7 No No
10 empty 2.13 55.1 8.8 No No
4ATI_A Microphthalmia-associated transcription factor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 64.4 25.3 Yes No
2 empty 1.81 62.3 12.8 No No
3 empty 1.67 65 10 No No
4 empty 2.32 58 11.7 No No
5 empty 2.71 69 8.1 No No
6 empty 2.28 58.7 7.8 No No
7 empty 3.32 67.7 5.7 No No
8 empty 2.65 35.9 7.6 No No
9 empty 1.7 64.2 5.5 No No
10 empty 3.4 69.7 7.6 No No
4ATK_B Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 60.8 23.9 No No
2 empty 1.6 63.6 13 No No
3 empty 2.07 66.5 10.5 No No
4 empty 2.5 55.4 16.3 No No
5 empty 2.93 69 6.7 No No
6 empty 2.31 57.9 6.9 No No
7 empty 2.7 77.4 5.5 No No
8 empty 1.94 46.3 7.5 No No
9 empty 3.16 72 5.4 No No
10 empty 3.08 71.6 4.9 No No
4ATI_B Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 63.3 19.4 No No
2 empty 1.95 67.9 11.1 No No
3 empty 3.23 61.1 10.9 No No
4 empty 1.08 68.5 12.1 No No
5 empty 2.34 60.8 8.6 No No
6 empty 2.79 57.6 12.1 No No
7 empty 2.88 53.3 8.7 No No
8 empty 2.55 66.2 12.8 No No
9 empty 3.01 62.8 7.2 No No
10 empty 2.34 62.2 10.7 No No
6FX5_B Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 63.6 13.4 No No
2 empty 2.03 66.2 14.7 No No
3 empty 1.11 70.5 11.3 No No
4 bound 2.5 66.3 7.3 No No
5 empty 2.77 65.5 6.4 No No
6 empty 2.4 65.7 5.8 No No
7 empty 2.86 56.3 6.2 No No
8 empty 2.54 52.1 7.7 No No
9 empty 2.77 72.3 6.6 No No
10 empty 1.56 60.4 6.5 No No
4ATH_B Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.16 68.7 13.9 No No
2 empty 2.63 58.2 14.9 No No
3 empty 1.89 66.6 11.7 No No
4 empty 2.01 66.4 11.1 No No
5 empty 2.7 52.7 8 No No
6 empty 2.48 55.6 8.7 No No
7 empty 2.15 55.7 8.5 No No
8 empty 3.09 64.9 8.1 No No
9 bound 2.29 51.5 8.9 No No
10 empty 2.32 47.6 7.9 No No
6G1L_A Microphthalmia-associated transcription factor No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 61 17.6 No No
2 empty 1.95 65.3 10.8 No No
3 empty 2.76 54.1 9.9 No No
4 empty 1.79 68.3 10.5 No No
5 empty 2.56 60.9 10.9 No No
6 empty 2.81 60.3 12.5 No No
7 empty 2.06 55.2 10.6 No No
8 empty 2.93 53.7 11.6 No No
9 empty 2.61 75.7 0 No No
10 empty 2.71 56.1 10.6 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score