Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Gene Expression
Gene Copy Number Variation
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Mitf (Q08874) - Overview - Molecular Target Synopsis

Protein


Mitf, Microphthalmia-associated transcription factor
UniProt Q08874

Also Known as MITF_MOUSE, Mitf, Bw, Mi, Vit

Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) (PubMed:23207919). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. Homodimer or heterodimer; dimerization is mediated via the coiled coil region (PubMed:23207919). Efficient DNA binding requires dimerization with another bHLH protein (PubMed:23207919). Binds DNA in the form of homodimer or heterodimer with either TFE3, TFEB or TFEC (By similarity). Binds DNA as a homodimer (in vitro) (PubMed:23207919). Interacts with KARS (PubMed:14975237). Identified in a complex with HINT1 and CTNNB1 (By similarity). Interacts with VSX2 (PubMed:23028343).

6FX5
MITF DIMERIZATION MUTANT
RCSB/PDB
Inspect Structure
See all 3D Structures for Mitf

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
526Q08874-1
510Q08874-4
470Q08874-2
454Q08874-7
419Q08874-3
419Q08874-8
413Q08874-9
374Q08874-5
349Q08874-6

Sub-cellular localization


UniProt: Mitf is active in the following subcellular-locations: nucleus.
GO terms: Mitf is active in the following subcellular-locations: nucleus, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Mitf has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Mitf there are:
5 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Mitf has been screened with 1 compounds (10 bioactivities). (see details)