Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCY1 (Q08828) - Overview - Molecular Target Synopsis

Protein


ADCY1, Adenylate cyclase type 1
Enzyme Classification 4.6.1.1
UniProt Q08828

Also Known as ADCY1_HUMAN, ADCY1

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca(2+)/calmodulin levels (By similarity). May be involved in regulatory processes in the central nervous system. May play a role in memory and learning. Plays a role in the regulation of the circadian rhythm of daytime contrast sensitivity probably by modulating the rhythmic synthesis of cyclic AMP in the retina. Interacts with CALM.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1119ENSG00000164742ENST00000297323ENSP00000297323Q08828-1
338ENSG00000164742ENST00000432715ENSP00000392721

Sub-cellular localization


UniProt: ADCY1 is active in the following subcellular-locations: cell membrane, cytoplasm, membrane, membrane raft.
GO terms: ADCY1 is active in the following subcellular-locations: cytoplasm, extracellular exosome, glutamatergic synapse, hippocampal mossy fiber to CA3 synapse, integral component of plasma membrane, integral component of postsynaptic density membrane, membrane raft, nucleus, plasma membrane, Schaffer collateral - CA1 synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCY1 has gain in 8 cell-lines, loss in 1 cell-lines and no signal in 996 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, UACC_257, RPMI_8226

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KMS-27, HT-144, HCC2911

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 50% identity similarity to ADCY1 there are:
17 structures (34 chains) solved
17 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADCY1 has been screened with 100 compounds (286 bioactivities), 65 compounds have bioactivities that show binding affinity of <= 500nM (93 bioactivities). (see details)