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Rabggtb (Q08603) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed22
Chains with at least one site assessed as druggable using the strict criteria12
Chains with at least one site assessed as druggable using the relaxed criteria22


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3DSU_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 69.6 43.6 Yes No
2 empty 2.36 65 36.4 No No
3 empty 2.11 74.8 19.3 No No
4 empty 2.13 65.9 23.2 No No
5 empty 2.36 70.9 12.8 No No
6 empty 2.08 67.6 12.8 No No
7 empty 2.58 54.9 17.2 No No
8 empty 2.57 58.2 20.1 No No
9 bound 2.5 69.6 10.4 No No
10 empty 2.13 65.9 9.8 No No
3DSW_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.36 70.9 42.2 Yes No
2 empty 2.31 67.2 29.6 No No
3 empty 2.07 72.6 18.1 No No
4 empty 2.17 65.9 22.7 No No
5 empty 2.2 60.9 23.1 No No
6 empty 2.02 67 12.8 No No
7 empty 2.37 66.6 11.4 No No
8 empty 2.35 61.9 17.3 No No
9 empty 2.48 56.4 16.8 No No
10 empty 2.48 69.4 9 No No
4GTT_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.24 70.7 39.8 Yes No
2 empty 2.27 65.4 32.8 No No
3 empty 2.1 71.6 20.8 No No
4 empty 1.98 65.7 22.2 No No
5 empty 2.26 64.2 15.9 No No
6 empty 2.23 61.2 18.5 No No
7 empty 2.39 67 12.2 No No
8 empty 2.48 53.2 15.6 No No
9 empty 2.09 65.3 11.3 No No
10 empty 2.28 71.1 8.6 No No
3DSV_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 67.3 47.3 Yes Yes
2 empty 2.34 65.5 36.2 No No
3 empty 2.12 76.8 15.2 No No
4 empty 1.98 64.8 19.4 No No
5 empty 2.38 67.5 15.9 No No
6 empty 2.52 65.9 15.9 No No
7 empty 2.18 58.3 12.3 No No
8 empty 2.32 61.5 20.9 No No
9 empty 2.51 55.7 14.7 No No
10 empty 2.2 53.9 14.3 No No
4GTS_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.41 69.5 38 Yes No
2 empty 2.28 67.2 36.8 No No
3 empty 2.11 72.1 18.8 No No
4 empty 2.18 61.5 22.5 No No
5 empty 2.04 67.9 19 No No
6 empty 2.43 62.3 17.5 No No
7 empty 2.21 69.9 11.5 No No
8 empty 2.25 66.5 14.6 No No
9 empty 2.15 64.5 8.7 No No
10 empty 2.58 65.9 7.1 No No
3PZ2_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 68.8 30.9 Yes Yes
2 bound 1.5 69.2 38.1 No No
3 empty 1.96 64.8 21.8 No No
4 empty 2.31 65.8 30.4 No No
5 empty 2.08 69.2 11.6 No No
6 empty 2.23 64.6 12.6 No No
7 empty 2.29 62.7 12.7 No No
8 empty 2.41 70.6 11.1 No No
9 empty 2.26 69.2 9.5 No No
10 empty 2.12 65.2 10.7 No No
4EHM_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.26 72 38.3 Yes Yes
2 empty 2.47 65.2 22.4 No No
3 empty 2.08 66.6 20.8 No No
4 empty 2.22 68.4 15.8 No No
5 empty 2.38 68.1 11 No No
6 empty 2.24 74 10.9 No No
7 empty 2.17 63.9 17.1 No No
8 empty 2.6 60.2 13.3 No No
9 empty 2.29 63.1 10.3 No No
10 empty 2.28 65.1 9.5 No No
3HXB_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.3 70.4 38.6 Yes No
2 empty 1.98 73.9 16.5 No No
3 empty 2.2 68.1 22.4 No No
4 empty 2.24 65.3 22.3 No No
5 empty 2.03 70.6 16.9 No No
6 empty 2.34 64.4 11.5 No No
7 empty 2.25 65.5 13 No No
8 empty 2.35 60.2 19.9 No No
9 empty 2.42 65.6 13.5 No No
10 empty 2.31 59.1 13.6 No No
4GTV_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 70.4 41.4 Yes No
2 empty 2.05 73.1 18.4 No No
3 empty 2.39 64.4 18.3 No No
4 empty 2.06 67 21.3 No No
5 empty 2.28 72 15.5 No No
6 empty 1.99 72 12.7 No No
7 empty 1.98 57.3 16.8 No No
8 empty 2.5 62.2 16.7 No No
9 empty 2.43 56 17.2 No No
10 empty 2.03 66.4 8.6 No No
3DSX_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.35 69.6 37.3 Yes Yes
2 empty 2.32 66.2 30 No No
3 empty 2.1 72.5 17.1 No No
4 empty 2.07 62.9 22.8 No No
5 empty 2.41 67.2 16.2 No No
6 empty 2.39 68.2 9.8 No No
7 empty 2.02 62.3 17.4 No No
8 empty 2.48 58.2 17.1 No No
9 empty 2.6 62.2 24.5 No No
10 empty 2.49 66.1 10.4 No No
1DCE_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 72.9 38.6 Yes Yes
2 empty 2.64 63.8 24.7 No No
3 empty 2.23 64.9 20.1 No No
4 empty 2.17 62.8 20.3 No No
5 empty 2.64 61.6 20.9 No No
6 empty 2.24 60.7 15.8 No No
7 empty 2.22 60.7 18.6 No No
8 empty 2.29 76.1 10.7 No No
9 empty 2.68 61.2 18 No No
10 empty 2.45 61.7 10.7 No No
3HXD_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.33 70.7 39.9 Yes Yes
2 empty 2.08 73.5 18.8 No No
3 empty 2.44 64.7 20.4 No No
4 empty 1.97 64.7 19 No No
5 empty 2.05 64 17.7 No No
6 empty 2.53 68.9 12.8 No No
7 empty 2.07 71 13 No No
8 empty 2.45 64.6 13.8 No No
9 empty 2.33 60.9 15.2 No No
10 empty 2.07 60.1 9.9 No No
3HXC_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.36 70 39.3 Yes No
2 empty 2.07 73.9 17 No No
3 empty 2.42 64.3 32.9 No No
4 empty 1.99 65.2 19.2 No No
5 empty 2.4 67.8 15.1 No No
6 empty 2.43 66.8 15.2 No No
7 empty 2 73.8 14.8 No No
8 empty 2.44 63.3 18.2 No No
9 empty 2.47 55.8 15.7 No No
10 empty 2.2 62.3 10.5 No No
1DCE_D Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 71.1 35.7 Yes No
2 empty 1.83 72.2 19.5 No No
3 empty 2.45 61.5 37.2 No No
4 empty 2.15 64.7 24.5 No No
5 empty 2.23 72.5 14.5 No No
6 empty 2.07 59.4 17.1 No No
7 empty 2.55 61.7 17.6 No No
8 empty 2.03 68.7 15 No No
9 empty 2.42 63.5 16 No No
10 empty 2.44 60.9 10.3 No No
1LTX_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.41 69.8 43.9 Yes Yes
2 empty 2.26 61.6 39.9 No No
3 empty 1.98 67.5 16.2 No No
4 empty 2.47 70.4 17.8 No No
5 empty 2.32 58.4 18.7 No No
6 empty 2.09 62.9 12.6 No No
7 empty 2.42 52.7 13 No No
8 empty 2.44 73.6 8.3 No No
9 empty 2.32 68.6 8.4 No No
10 empty 1.96 65.6 12.3 No No
3HXE_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 70 26.8 Yes Yes
2 bound 1.39 75.5 23.7 Yes No
3 empty 2.41 63.6 36.8 No No
4 empty 2.33 68.8 16.7 No No
5 empty 1.98 67.2 13.5 No No
6 empty 2.44 67.3 13.8 No No
7 empty 1.97 69.8 17.4 No No
8 empty 2.64 62.3 15.8 No No
9 empty 2.52 67.9 11.2 No No
10 empty 2.12 62.2 10 No No
3HXF_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.42 70.3 43 Yes Yes
2 empty 2.09 65.3 21.1 No No
3 empty 2.32 61.6 23.5 No No
4 empty 2.39 72.8 13.6 No No
5 empty 1.91 72.8 11.7 No No
6 empty 2.38 61.3 17.6 No No
7 empty 2.53 57.1 15.4 No No
8 empty 2.18 63.2 9.4 No No
9 bound 2.37 68.8 9.7 No No
10 empty 2.18 61.9 13.5 No No
3PZ1_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.45 71.3 37.7 Yes Yes
2 empty 2.02 72.4 20.1 No No
3 empty 2.44 65.8 33 No No
4 empty 2.16 67 21.1 No No
5 empty 2.11 73.2 17.3 No No
6 empty 1.97 56.2 16.7 No No
7 empty 2.23 72.6 9.3 No No
8 empty 2.61 74.2 9.9 No No
9 empty 2.29 66.6 10.4 No No
10 empty 2.1 61.8 10 No No
3DSS_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.25 70.8 45.3 Yes No
2 empty 2.22 70 23.9 No No
3 empty 2.52 65.8 38.6 No No
4 empty 1.95 64.8 18.7 No No
5 empty 2.2 67.9 12 No No
6 empty 1.85 55.2 16.5 No No
7 empty 2.03 72 9.9 No No
8 empty 2.31 62.2 10.7 No No
9 empty 2.38 62.8 13.2 No No
10 empty 2.1 63.9 10.4 No No
3DST_B Geranylgeranyl transferase type-2 subunit beta Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.44 69.9 42.4 Yes No
2 empty 2.32 63.9 38 No No
3 empty 2.22 76.2 17 No No
4 empty 2.18 65.4 23.1 No No
5 empty 2.46 67.5 17.7 No No
6 empty 2.49 64.8 23.7 No No
7 empty 2.42 61.4 10.9 No No
8 empty 2.14 60.3 10.2 No No
9 empty 2.6 56.5 12.8 No No
10 bound 2.48 70.2 10.9 No No
3PZ3_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.35 70.4 38.6 Yes Yes
2 empty 2.27 66.3 34 No No
3 empty 2.15 73.5 21.6 No No
4 empty 1.98 66.8 19.4 No No
5 empty 2.42 67.1 15 No No
6 empty 2.07 61.3 17 No No
7 empty 2.41 63 17.6 No No
8 empty 2.48 64.1 15.8 No No
9 empty 2.43 64.2 15.2 No No
10 empty 2.42 63.8 11.8 No No
3C72_B Geranylgeranyl transferase type-2 subunit beta Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.27 70.1 44.5 Yes Yes
2 empty 2.01 71.9 21.5 No No
3 empty 2.15 65.1 22.1 No No
4 empty 2.26 61.8 19.7 No No
5 empty 2.54 63.1 13 No No
6 empty 2.34 68.1 12.1 No No
7 empty 2.02 73.1 18.1 No No
8 empty 2.15 62.3 14.9 No No
9 empty 2.43 65.1 13.5 No No
10 empty 2.52 65.7 15.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed10
Domains assessed as druggable using the strict criteria6
Domains assessed as druggable using the relaxed criteria10

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1DCE_B (18872) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 2Å Yes Yes
1DCE_D (18873) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 2Å Yes Yes
1LTX_B (84714) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 2.7Å Yes Yes
3C72_B (155997) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 2.3Å Yes Yes
3DSS_B (157841) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 1.8Å Yes No
3DST_B (157842) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 1.9Å Yes No
3DSU_B (157843) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 1.9Å Yes No
3DSV_B (157844) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 2.1Å Yes Yes
3DSW_B (157845) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 2.15Å Yes No
3DSX_B (157846) Geranylgeranyl transferase type-2 subunit beta alpha/alpha toroid, Terpenoid cyclases/Protein prenyltransferases, Protein prenyltransferases 2.1Å Yes Yes
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score