Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Rabggtb (Q08603) - Overview - Molecular Target Synopsis

Protein


Rabggtb, Geranylgeranyl transferase type-2 subunit beta
Enzyme Classification 2.5.1.60
UniProt Q08603

Also Known as PGTB2_RAT, Rabggtb, Ggtb

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp. Interaction of RABGGTB with prenylated PTP4A2 precludes its association with RABGGTA and inhibits enzyme activity. Interacts with CHODL.

4GTT
ENGINEERED RABGGTASE IN COMPLEX WITH BMS ANALOGUE 12
RCSB/PDB
Inspect Structure
See all 3D Structures for Rabggtb

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
331Q08603-1

Sub-cellular localization


GO terms: Rabggtb is active in the following subcellular-locations: Rab-protein geranylgeranyltransferase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Rabggtb has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Rabggtb there are:
21 structures (22 chains) solved
17 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Rabggtb has been screened with compounds ( bioactivities). (see details)