Molecular Target Synopsis
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Rabggta (Q08602) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed22
Chains with at least one site assessed as druggable using the strict criteria4
Chains with at least one site assessed as druggable using the relaxed criteria21


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3C72_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 65.5 27.2 Yes No
2 empty 2.16 70.2 22.8 No No
3 empty 2.01 68.2 24.9 No No
4 empty 2.26 58.8 22 No No
5 empty 1.7 69.1 13.9 No No
6 empty 2 65.6 18.4 No No
7 empty 2.19 67.4 18.7 No No
8 empty 1.74 61.2 20.1 No No
9 empty 1.58 71.1 12.3 No No
10 empty 2.01 65.9 11 No No
3HXC_A Geranylgeranyl transferase type-2 subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 66.8 27.5 Yes Yes
2 empty 2.02 71.8 23.4 No No
3 empty 2.15 68.8 17.7 No No
4 empty 1.79 73.1 18 No No
5 empty 1.54 64.2 12.5 No No
6 empty 2.2 81.3 15.4 No No
7 empty 2.26 70.1 17.6 No No
8 empty 1.58 70.4 10.8 No No
9 empty 2.27 61.3 12.9 No No
10 empty 1.6 73.3 11.4 No No
4GTV_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 63.3 28.4 Yes No
2 empty 1.98 73.7 23.7 No No
3 empty 2.32 68.8 16.9 No No
4 empty 2.13 62.9 18.6 No No
5 empty 2.15 61 18.4 No No
6 empty 2.07 82.5 12.9 No No
7 empty 1.79 70.3 17.8 No No
8 empty 2.15 66.1 17.2 No No
9 empty 2.27 69.5 12.4 No No
10 empty 1.44 63.7 15.7 No No
1DCE_C Geranylgeranyl transferase type-2 subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 73.3 43.4 Yes Yes
2 empty 2.1 53.8 27.9 No No
3 empty 2.03 69 22 No No
4 empty 2.11 66 20.4 No No
5 empty 2.09 69 20.4 No No
6 empty 2.57 62.8 23 No No
7 empty 2.39 72 24.9 No No
8 empty 2.11 62.8 18.5 No No
9 empty 1.95 62.6 26.7 No No
10 empty 2.04 59.8 21 No No
1DCE_A Geranylgeranyl transferase type-2 subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 70.6 48.9 Yes Yes
2 empty 2.11 57.4 45.5 No No
3 empty 1.81 68.2 21.8 No No
4 empty 2.09 66.9 19.7 No No
5 empty 2.13 67.3 21.9 No No
6 empty 2.31 63.7 22.4 No No
7 empty 1.98 71.1 26.9 No No
8 empty 1.92 63.7 13 No No
9 empty 2.69 66.8 16.4 No No
10 empty 2.2 62.5 19.4 No No
4EHM_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 61.3 30.4 Yes No
2 bound 2.01 54.2 20.9 No No
3 empty 2.14 58.7 17.4 No No
4 empty 1.98 65.2 17.5 No No
5 empty 1.34 30.7 15 No No
6 empty 2.13 71.8 12.4 No No
7 empty 1.43 67.8 14.8 No No
8 empty 1.87 57 17.2 No No
9 empty 1.55 72.2 10.7 No No
10 empty 1.92 54.1 14 No No
3DSW_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 54.6 33.8 Yes No
2 empty 1.85 74.8 16.6 No No
3 empty 2.16 70.3 28.6 No No
4 empty 2.02 62 18.1 No No
5 empty 1.81 71.9 16.9 No No
6 empty 1.97 58 16.8 No No
7 empty 1.97 67.1 17.3 No No
8 empty 2.19 78.6 12.7 No No
9 empty 2.3 70.9 13 No No
10 empty 1.57 71.5 13.8 No No
4GTS_A Geranylgeranyl transferase type-2 subunit alpha No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 70.3 15.9 No No
2 empty 2 70.5 19.7 No No
3 empty 2.09 58 19.4 No No
4 empty 1.81 67.4 24.3 No No
5 empty 2.13 63.8 28.6 No No
6 empty 2.07 68 16.8 No No
7 empty 1.93 59 21.3 No No
8 empty 1.47 66.9 14.4 No No
9 empty 2.2 81.2 11.2 No No
10 empty 2.02 65.6 12.4 No No
3PZ1_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 60.6 31 Yes No
2 empty 2.09 66.2 22.4 No No
3 empty 2 57.3 16.8 No No
4 empty 2.09 67.5 17.1 No No
5 empty 1.75 71.4 18 No No
6 empty 2.12 69 12.3 No No
7 empty 2.11 79.8 12.6 No No
8 empty 1.66 66.1 15.9 No No
9 empty 2.21 69.8 14.2 No No
10 empty 1.59 69.6 12.5 No No
3HXF_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 64.9 27.7 Yes No
2 empty 2.11 72.9 23.9 No No
3 empty 1.46 55.7 15.3 No No
4 empty 2.22 68.3 19.5 No No
5 empty 1.79 70.2 17.7 No No
6 empty 1.86 68.1 13.5 No No
7 empty 1.87 70.7 12.7 No No
8 empty 2 61.6 18.7 No No
9 empty 1.51 63.7 17.4 No No
10 empty 1.64 67.9 15.7 No No
3HXD_A Geranylgeranyl transferase type-2 subunit alpha Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 67.4 27.8 Yes Yes
2 empty 2.04 69.5 21.5 No No
3 empty 1.61 61.3 16.5 No No
4 empty 2.21 68.6 18 No No
5 empty 1.77 71.8 17.4 No No
6 empty 2.19 74.9 12.5 No No
7 empty 2.28 69.8 12.4 No No
8 empty 1.91 61.1 17.9 No No
9 empty 1.65 71 11.3 No No
10 empty 2.08 66.7 10.3 No No
1LTX_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 74 27.8 Yes No
2 empty 2.23 65.6 33.3 No No
3 empty 1.85 71.4 21.2 No No
4 empty 2.43 67.9 27.4 No No
5 empty 2.01 69.9 32.6 No No
6 empty 2.01 58.1 15.6 No No
7 empty 1.93 56.3 20.8 No No
8 empty 2.21 70.3 13.4 No No
9 empty 2.04 53.1 16.9 No No
10 empty 2.18 63.3 19.4 No No
3DSU_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 62.6 26.1 Yes No
2 empty 1.98 72 22.6 No No
3 empty 1.93 70.1 24.5 No No
4 empty 1.79 62.3 22.8 No No
5 empty 2.05 61.2 21 No No
6 empty 2.2 81.6 12.8 No No
7 empty 2.06 65.2 13.7 No No
8 empty 2.27 69.2 12.9 No No
9 empty 2.33 73.4 13.1 No No
10 empty 1.58 71.5 13.6 No No
4GTT_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.73 64.9 28.4 Yes No
2 empty 1.96 70.4 20.5 No No
3 empty 1.9 68.2 23.2 No No
4 empty 2.19 83.3 12.9 No No
5 empty 2.16 60 19.6 No No
6 empty 2.1 65.5 15.8 No No
7 empty 1.4 63.7 12.8 No No
8 empty 2.13 67.4 14.4 No No
9 empty 1.57 70.5 13.5 No No
10 empty 1.59 75.3 10.4 No No
3HXE_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 65.9 27.4 Yes No
2 empty 2.01 70.2 21.4 No No
3 empty 1.71 62.1 15.2 No No
4 empty 1.77 72.2 18.7 No No
5 empty 1.82 69.4 14.9 No No
6 empty 1.55 65.3 16 No No
7 empty 1.6 71.1 12.9 No No
8 empty 1.95 62.4 18.8 No No
9 empty 2.26 69.5 13.1 No No
10 empty 1.59 72.5 11.3 No No
3PZ3_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 71.8 28 Yes No
2 empty 1.79 70.9 18 No No
3 empty 1.87 56.9 19.4 No No
4 empty 2.1 59.5 18.6 No No
5 empty 1.75 73.4 17.5 No No
6 empty 2.1 66.7 16.8 No No
7 empty 1.43 66.7 12.5 No No
8 empty 2.2 80.5 12.5 No No
9 empty 2.32 68.5 15.6 No No
10 empty 1.87 63.4 18.7 No No
3DSV_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.06 55.9 28.2 Yes No
2 empty 1.65 61.6 26.1 No No
3 empty 2.12 69.9 28.7 No No
4 empty 2.05 63.3 19.3 No No
5 empty 1.75 73 18 No No
6 empty 2.38 65.2 13.6 No No
7 empty 2.23 70.4 17.5 No No
8 empty 1.55 66.2 13.3 No No
9 empty 1.95 68.6 14.8 No No
10 empty 2.23 80.3 13.4 No No
3PZ2_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 59.8 32.3 Yes No
2 empty 2.08 68.9 23.3 No No
3 empty 1.84 58.4 16.4 No No
4 empty 2.12 74.7 13 No No
5 empty 2.07 65.5 19.8 No No
6 empty 1.71 75.8 15.8 No No
7 empty 1.69 68.9 16.7 No No
8 empty 1.56 68.7 14.4 No No
9 empty 2.03 66.9 11.2 No No
10 empty 2.15 62.6 17 No No
3DSX_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.98 56.9 31.2 Yes No
2 empty 1.85 73.9 16.5 No No
3 empty 2.1 65.7 23 No No
4 empty 2.14 67.2 17.1 No No
5 empty 1.97 64.2 19.1 No No
6 empty 1.8 70.6 17.7 No No
7 empty 2.08 79.4 13.3 No No
8 empty 1.45 64.5 13.7 No No
9 empty 1.56 68.2 14.3 No No
10 empty 1.92 53.1 17.3 No No
3DSS_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 71.3 21.3 Yes No
2 empty 2.14 62.2 19.2 No No
3 empty 1.81 74.5 17.2 No No
4 empty 2.12 83.8 15.4 No No
5 empty 2.17 63.4 18.8 No No
6 empty 2.37 63.8 20.2 No No
7 empty 2.23 72.3 15.2 No No
8 empty 2.06 62.9 20.5 No No
9 empty 1.82 67.4 13.5 No No
10 empty 1.58 70.8 13.1 No No
3HXB_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.91 64.4 26.6 Yes No
2 empty 1.89 64.4 27.6 No No
3 empty 2.03 70.4 28.3 No No
4 empty 2.23 72.8 28.5 No No
5 empty 2.31 68.7 28 No No
6 empty 2.3 66.7 18.7 No No
7 empty 1.75 54.3 15.1 No No
8 empty 1.77 72.9 17 No No
9 empty 2.21 61.4 13.5 No No
10 empty 2.02 67 15.1 No No
3DST_A Geranylgeranyl transferase type-2 subunit alpha Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 63.6 26.5 Yes No
2 empty 2.06 63.2 22.7 No No
3 empty 2.3 70 24.9 No No
4 empty 2.06 64 28.5 No No
5 empty 1.78 68.4 22.2 No No
6 empty 1.94 61.3 16.1 No No
7 empty 1.93 71.4 13 No No
8 empty 1.98 69.7 16.6 No No
9 empty 2.13 67.3 12.7 No No
10 empty 1.58 68.4 14 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed9
Domains assessed as druggable using the strict criteria2
Domains assessed as druggable using the relaxed criteria6

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1DCE_A (19191) Geranylgeranyl transferase type-2 subunit alpha alpha-alpha superhelix, Protein prenylyltransferase, Protein prenylyltransferase 2Å Yes Yes
1DCE_A (19191) Geranylgeranyl transferase type-2 subunit alpha alpha-alpha superhelix, Protein prenylyltransferase, Protein prenylyltransferase 2Å Yes Yes
1DCE_C (19192) Geranylgeranyl transferase type-2 subunit alpha alpha-alpha superhelix, Protein prenylyltransferase, Protein prenylyltransferase 2Å Yes Yes
1DCE_C (19192) Geranylgeranyl transferase type-2 subunit alpha alpha-alpha superhelix, Protein prenylyltransferase, Protein prenylyltransferase 2Å Yes Yes
1DCE_A (23218) Geranylgeranyl transferase type-2 subunit alpha C2 domain-like, Rab geranylgeranyltransferase alpha-subunit insert domain, Rab geranylgeranyltransferase alpha-subunit insert domain 2Å Yes No
1DCE_C (23219) Geranylgeranyl transferase type-2 subunit alpha C2 domain-like, Rab geranylgeranyltransferase alpha-subunit insert domain, Rab geranylgeranyltransferase alpha-subunit insert domain 2Å Yes No
1DCE_C (30868) Geranylgeranyl transferase type-2 subunit alpha Leucine-rich repeat LRR (right-handed beta-alpha superhelix), L domain-like, Rab geranylgeranyltransferase alpha-subunit C-terminal domain 2Å No No
1DCE_A (30867) Geranylgeranyl transferase type-2 subunit alpha Leucine-rich repeat LRR (right-handed beta-alpha superhelix), L domain-like, Rab geranylgeranyltransferase alpha-subunit C-terminal domain 2Å No No
1LTX_A (84713) Geranylgeranyl transferase type-2 subunit alpha Leucine-rich repeat LRR (right-handed beta-alpha superhelix), L domain-like, Rab geranylgeranyltransferase alpha-subunit C-terminal domain 2.7Å Yes No
1LTX_A (84711) Geranylgeranyl transferase type-2 subunit alpha alpha-alpha superhelix, Protein prenylyltransferase, Protein prenylyltransferase 2.7Å Yes No
1LTX_A (84711) Geranylgeranyl transferase type-2 subunit alpha alpha-alpha superhelix, Protein prenylyltransferase, Protein prenylyltransferase 2.7Å Yes No
1LTX_A (84712) Geranylgeranyl transferase type-2 subunit alpha C2 domain-like, Rab geranylgeranyltransferase alpha-subunit insert domain, Rab geranylgeranyltransferase alpha-subunit insert domain 2.7Å No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score