Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADCY2 (Q08462) - Overview - Molecular Target Synopsis

Protein


ADCY2, Adenylate cyclase type 2
Enzyme Classification 4.6.1.1
UniProt Q08462

Also Known as ADCY2_HUMAN, ADCY2, KIAA1060

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors. Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADCY2 is active in the following subcellular-locations: cell membrane, cytoplasm, membrane.
GO terms: ADCY2 is active in the following subcellular-locations: cytoplasm, dendrite, integral component of plasma membrane, membrane, membrane raft, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADCY2 has gain in 31 cell-lines, loss in 2 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, MALME_3M, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2198, 624 mel, MT-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to ADCY2 there are:
17 structures (18 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ADCY2 has been screened with 49 compounds (55 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (24 bioactivities). (see details)