Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ADCY2 (Q08462) - Overview - Molecular Target Synopsis


ADCY2, Adenylate cyclase type 2
Enzyme Classification
UniProt Q08462

Also Known as ADCY2_HUMAN, ADCY2, KIAA1060

Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642). Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors (By similarity). Interacts with RAF1 (PubMed:15385642). Interacts with GNAS. Interacts with the G protein beta and gamma subunit complex (By similarity).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: ADCY2 is active in the following subcellular-locations: cell membrane, cytoplasm, membrane.
GO terms: ADCY2 is active in the following subcellular-locations: cytoplasm, dendrite, integral component of plasma membrane, membrane, membrane raft, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ADCY2 has gain in 31 cell-lines, loss in 2 cell-lines and no signal in 972 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, MALME_3M, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2198, 624 mel, MT-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 90% identity similarity to ADCY2 there are:
17 structures (18 chains) solved
4 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ADCY2 has been screened with 49 compounds (55 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (24 bioactivities). (see details)