BAX (Q07812) - Overview - Molecular Target Synopsis
BAX, Apoptosis regulator BAX
Also Known as BAX_HUMAN, BAX, BCL2L4
Plays a role in the mitochondrial apoptotic process. Under normal conditions, BAX is largely cytosolic via constant retrotranslocation from mitochondria to the cytosol mediated by BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at the mitochondrial outer membrane (MOM) (PubMed:21458670). Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis. Homodimer. Forms higher oligomers under stress conditions. Forms heterooligomers with BAK (PubMed:29531808). Interacts with BCL2L11. Interaction with BCL2L11 promotes BAX oligomerization and association with mitochondrial membranes, with subsequent release of cytochrome c. Forms heterodimers with BCL2, BCL2L1 isoform Bcl-X(L), BCL2L2, MCL1 and A1. Interacts with SH3GLB1 and HN. Interacts with SFN and YWHAZ; the interaction occurs in the cytoplasm. Under stress conditions, JNK-mediated phosphorylation of SFN and YWHAZ, releases BAX to mitochondria. Isoform Sigma interacts with BCL2A1 and BCL2L1 isoform Bcl-X(L). Interacts with RNF144B, which regulates the ubiquitin-dependent stability of BAX. Interacts with CLU under stress conditions that cause a conformation change leading to BAX oligomerization and association with mitochondria. Does not interact with CLU in unstressed cells. Interacts with FAIM2/LFG2. Interacts with RTL10/BOP. Interacts (via a C-terminal 33 residues) with NOL3 (via CARD domain); inhibits BAX activation and translocation and consequently cytochrome c release from mitochondria.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|164||ENSG00000087088||ENST00000356483, ENST00000539787||ENSP00000348871, ENSP00000441413||Q07812-5|
|41||ENSG00000087088||ENST00000391871, ENST00000515540||ENSP00000375744, ENSP00000426328||Q07812-3|
UniProt: BAX is active in the following subcellular-locations: cytoplasm, mitochondrion outer membrane.
GO terms: BAX is active in the following subcellular-locations: BAX complex, Bcl-2 family protein complex, cytoplasm, cytosol, endoplasmic reticulum, endoplasmic reticulum membrane, extracellular exosome, membrane, mitochondrial outer membrane, mitochondrial permeability transition pore complex, mitochondrion, nuclear envelope, nucleus, pore complex.