Molecular Target Synopsis
Overview
Domains and Structures
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Druggability
Chemistry
Ligand Efficiency Plot
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Gene Copy Number Variation
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TJP1 (Q07157) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP3 (O95049) - HUMAN 3KFV_A 51.82 2.0E-78 2.8Å - 2009-11-03
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 4OEP_A 100 0 2.35Å 12P 2015-01-14
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 4Q2Q_A 100 0 1.45Å - 2014-09-10
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2H3M_A 100 0 2.8Å - 2006-06-13
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 4OEP_B 100 0 2.35Å - 2015-01-14
PDZ domain (100%) (view alignment) DLG1 (Q12959) APC (P25054) HUMAN 3RL7_B 36.08 2.0E-11 2.3Å - 2011-12-14
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2RCZ_B 100 0 1.7Å - 2007-10-09
PDZ domain (99%) (view alignment) TJP2 (Q9UDY2) - HUMAN 2OSG_B 70.13 2.0E-27 - 2007-09-25
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2H2B_A 100 0 1.6Å - 2006-06-13
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2H2C_A 100 0 2Å - 2006-06-13
PDZ domain (100%), Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP1 (Q07157) - HUMAN 3TSW_D 100 0 2.83Å - 2011-10-12
PDZ domain (100%) (view alignment) TJP1 (Q07157) Gja1 (P08050) HUMAN 3CYY_B 100 0 2.4Å - 2008-09-23
PDZ domain (100%) (view alignment) DLG1 (Q12959) APC (P25054) HUMAN 3RL7_A 36.08 2.0E-11 2.3Å - 2011-12-14
PDZ domain (100%), Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP1 (Q07157) GJC1 (P36383) HUMAN 3SHW_A 100 0 2.9Å - 2011-09-28
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 3SHU_A 100 0 2.75Å - 2011-09-28
PDZ domain (100%), Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP1 (Q07157) - HUMAN 3TSW_C 100 0 2.83Å - 2011-10-12
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2JWE_A 100 0 - 2007-10-30
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 3SHU_B 100 0 2.75Å - 2011-09-28
PDZ domain (100%) (view alignment) Tjp1 (P39447) - MOUSE 2RRM_A 100 5.0E-51 - 2011-05-25
PDZ domain (100%) (view alignment) CLDN2 (P57739), TJP1 (Q07157) - HUMAN 4YYX_A 100 0 1.79Å - 2015-04-01
PDZ domain (100%) (view alignment) DLG1 (Q12959) APC (P25054) HUMAN 3RL7_D 36.08 2.0E-11 2.3Å - 2011-12-14
ZU5 domain (91%) (view alignment) Unc5b (O08722) - RAT 3G5B_A 42.35 8.0E-14 2Å - 2009-04-07
Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP1 (Q07157) - 3LH5_A 100 0 2.6Å - 2010-03-02
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 4OEO_A 100 0 1.89Å - 2015-01-14
PDZ domain (100%) (view alignment) DLG1 (Q12959) APC (P25054) HUMAN 3RL7_E 36.08 2.0E-11 2.3Å - 2011-12-14
PDZ domain (100%), Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP1 (Q07157) - HUMAN 3TSW_B 100 0 2.83Å - 2011-10-12
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 4OEO_C 100 0 1.89Å 12P 2015-01-14
ZU5 domain (100%) (view alignment) MYZAP (P0CAP1), TJP1 (Q07157) - HUMAN, SYNTHETIC, HUMAN 2KXS_A 100 0 - 2011-03-30
PDZ domain (100%) (view alignment) DLG1 (Q12959) APC (P25054) HUMAN 3RL7_C 36.08 2.0E-11 2.3Å - 2011-12-14
PDZ domain (100%) (view alignment) CLDN2 (P57739), TJP1 (Q07157) - HUMAN 4YYX_B 100 0 1.79Å - 2015-04-01
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2RCZ_A 100 0 1.7Å - 2007-10-09
PDZ domain (99%) (view alignment) TJP2 (Q9UDY2) - HUMAN 2OSG_A 70.13 2.0E-27 - 2007-09-25
ZU5 domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2KXR_A 100 0 - 2011-03-30
PDZ domain (100%), Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP1 (Q07157) F11R (Q9Y624) HUMAN 3TSZ_A 100 0 2.5Å - 2011-10-12
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 2JWE_B 100 0 - 2007-10-30
PDZ domain (100%) (view alignment) DLG1 (Q12959) APC (P25054) HUMAN 3RL7_F 36.08 2.0E-11 2.3Å - 2011-12-14
PDZ domain (100%) (view alignment) TJP1 (Q07157) Gja1 (P08050) HUMAN 3CYY_A 100 0 2.4Å - 2008-09-23
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 3TSV_A 100 0 1.989Å - 2011-10-12
PDZ domain (99%) (view alignment) TJP2 (Q9UDY2) - HUMAN 3E17_A 70.13 2.0E-27 1.75Å - 2009-07-21
PDZ domain (99%) (view alignment) TJP2 (Q9UDY2) - HUMAN 3E17_B 70.13 2.0E-27 1.75Å - 2009-07-21
PDZ domain (100%) (view alignment) Tjp2 (Q9Z0U1) - HOUSE MOUSE 2CSJ_A 69.9 1.0E-36 - 2005-11-21
PDZ domain (100%) (view alignment) TJP1 (Q07157) - HUMAN 4OEO_B 100 0 1.89Å 12P 2015-01-14
PDZ domain (100%), Variant SH3 domain (100%), Guanylate kinase (100%) (view alignment) TJP1 (Q07157) - HUMAN 3TSW_A 100 0 2.83Å - 2011-10-12