Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TJP1 (Q07157) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed30
Chains with at least one site assessed as druggable using the strict criteria7
Chains with at least one site assessed as druggable using the relaxed criteria23


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4OEP_A Tight junction protein ZO-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.89 65.8 14.2 No No
2 bound 2.32 71.8 16.3 No No
3 bound 2.25 61.9 16.4 No No
4 bound 1.79 54.6 10.8 No No
5 empty 2.7 61.7 11.7 No No
6 empty 2.37 49.7 8.5 No No
7 empty 2.06 61.2 8.8 No No
8 empty 2.77 56.8 9.3 No No
9 empty 2.28 68.3 6.4 No No
10 empty 2.83 65.1 7 No No
2H3M_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 71.3 17.8 Yes No
2 bound 1.93 66.9 18.4 No No
3 empty 2.55 66.4 13.1 No No
4 empty 1.96 58.4 10.7 No No
5 empty 2.42 71.4 6.2 No No
6 empty 1.57 62.7 9.2 No No
7 empty 2.76 71.7 0 No No
8 empty 2.5 58.8 7.1 No No
9 empty 2.63 62.1 7.5 No No
10 empty .15 100 0 Yes No
4Q2Q_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 65.6 34.3 Yes No
2 empty 2.46 65 9.4 No No
3 empty 2.26 62.3 12.3 No No
4 empty 2.34 62.5 12.2 No No
5 empty 2.37 56.3 11.3 No No
6 empty 2.79 58.3 8.6 No No
7 empty 3.05 60.6 11.1 No No
8 empty 2.65 62.4 5.6 No No
9 empty 1.57 63 8.2 No No
10 empty 2.63 63.9 5.7 No No
4OEP_B Tight junction protein ZO-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 57.4 22.8 No No
2 empty 2.1 58.6 22.8 No No
3 empty 1.66 68.8 9.6 No No
4 empty 2.77 65.2 17.7 No No
5 empty 2.39 72 5.8 No No
6 empty 2.07 58.1 11.7 No No
7 empty 3.08 67.7 6.1 No No
8 empty 2.92 64.5 5.6 No No
9 empty 2.28 72.2 6 No No
10 empty 2.5 58.5 5 No No
2RCZ_B Tight junction protein ZO-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 67.8 28.4 Yes Yes
2 empty 2.09 57.8 14 No No
3 empty 2.78 55.2 17.4 No No
4 empty 2.49 62.8 13.9 No No
5 empty 1.59 45.2 11.4 No No
6 empty 2.79 50.3 11 No No
7 empty 3.16 55.8 8.7 No No
8 empty 3.06 73.2 6 No No
9 empty 3.49 55.3 6.5 No No
10 empty 2.92 63 7.4 No No
2H2B_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.43 62.8 25.2 Yes No
2 empty 2.3 55.9 19.7 No No
3 empty 1.92 67.7 11.1 No No
4 empty 2.55 57 12.5 No No
5 empty 2.5 50.6 11.7 No No
6 empty 1.84 17.4 9.9 No No
7 empty 1.23 50.7 7.8 No No
8 empty 2.34 73.3 5.5 No No
9 empty 2.81 42.5 9.2 No No
10 empty 2.33 67.2 7.9 No No
2H2C_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 60.7 25.3 Yes No
2 empty 2.58 71.3 16.3 No No
3 empty 2.09 63.7 14.2 No No
4 empty 2.67 64.3 12.1 No No
5 empty 2.23 51.2 11.5 No No
6 empty 2.85 60.5 11.6 No No
7 empty 3.05 64.3 7.8 No No
8 empty 2.64 68.1 8 No No
9 empty 2.54 76 6.8 No No
10 empty 2.51 70.5 7.5 No No
3TSW_D Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 55.9 24.9 Yes No
2 empty 1.99 66.2 17.1 No No
3 bound 2.45 55.6 17.7 No No
4 empty 2.13 58.9 15 No No
5 empty 1.89 55.4 16.7 No No
6 empty 2.25 69.2 14 No No
7 empty 2.33 53.1 15.4 No No
8 empty 2.19 46.9 15.3 No No
9 empty 1.97 59.4 10.1 No No
10 empty 2.17 65.6 10.9 No No
3CYY_B Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 63.7 27.7 Yes No
2 empty 2.13 50.9 17 No No
3 empty 2.28 61.7 11.6 No No
4 empty 2.78 45.5 10.6 No No
5 empty 2.72 67.3 8.1 No No
6 empty 2.88 49 8.6 No No
7 empty 2.31 67.8 8.1 No No
8 empty 2.71 72.6 6.7 No No
9 empty 2.49 66.9 6.9 No No
10 empty 2.52 62.4 7.1 No No
3SHU_A Tight junction protein ZO-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.27 64 23.6 No No
2 empty 2.25 51.6 20.1 No No
3 empty 2.13 57.3 10.5 No No
4 empty 1.99 59.4 9.2 No No
5 empty 2.22 58.2 8.2 No No
6 empty 2.32 72.4 8.4 No No
7 empty 2.63 56.3 9.2 No No
8 empty 2.29 54.3 9.5 No No
9 empty 2.44 64.1 8.2 No No
10 empty 2.14 43.5 7.6 No No
3SHW_A Tight junction protein ZO-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 72.8 36.5 Yes Yes
2 empty 1.99 67.2 32.5 No No
3 empty 2.53 69.2 32 No No
4 empty 2.3 64.7 21.3 No No
5 empty 2.07 62 21.5 No No
6 empty 2.24 66.6 15.7 No No
7 empty 2.58 56.8 16.2 No No
8 empty 2.33 54.7 18.3 No No
9 empty 2.19 57.9 17.6 No No
10 empty 1.98 58.9 16.7 No No
3TSW_C Tight junction protein ZO-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 68.9 39.2 Yes Yes
2 empty 2.17 66.2 35.8 No No
3 empty 2.28 70.3 28.7 No No
4 empty 2.48 62.2 18.2 No No
5 empty 2.44 82.9 13.1 No No
6 empty 1.91 64.7 13.8 No No
7 empty 2.33 55.7 16.7 No No
8 empty 2.25 65.7 16.2 No No
9 empty 2.46 64.2 14.6 No No
10 empty 2.31 68.5 14.2 No No
2JWE_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 65 32.5 Yes No
2 empty 2.64 67.8 20.2 No No
3 empty 2.51 61.5 17.9 No No
4 empty 2.33 57.1 17.5 No No
5 empty 2.6 54.4 11.6 No No
6 empty 1.83 47 13.7 No No
7 empty 2.26 58.2 8.7 No No
8 empty 3.1 60 10.2 No No
9 empty 2.86 54.7 8 No No
10 empty 2.57 65.8 7.1 No No
3SHU_B Tight junction protein ZO-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.55 64.3 22.1 No No
2 empty 2.17 49.9 18.9 No No
3 empty 2.09 72.6 10.8 No No
4 empty 2.22 54.4 12.9 No No
5 empty 2.06 63.6 13.1 No No
6 empty 2.21 51.5 12 No No
7 empty 2.52 57.3 11.6 No No
8 empty 2.18 65.1 7.1 No No
9 empty 1.94 61.7 10.6 No No
10 empty 2.53 62.4 6.8 No No
2RRM_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.17 62.7 26.7 Yes No
2 empty 2.23 57.4 13.6 No No
3 empty 2.79 65.3 14.2 No No
4 empty 2.58 67.3 11.8 No No
5 empty 2.53 59.8 11.4 No No
6 empty 2.4 54.6 11.3 No No
7 empty 2.88 68.3 8.5 No No
8 empty 2.03 69.6 6.9 No No
9 empty 1.93 63 7.1 No No
10 empty 2.98 69.1 6.6 No No
4YYX_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.54 59.7 33 Yes No
2 empty 2.05 67.2 16 No No
3 empty 2.51 69.6 13.6 No No
4 empty 2.04 60.6 10.3 No No
5 empty 2.43 51.7 6.7 No No
6 bound 2.47 85.7 0 Yes No
7 empty 2.59 79.3 6.1 No No
8 empty 2.17 59.8 7.1 No No
9 empty 2.35 67 4.3 No No
10 empty 2.26 50 5.2 No No
3LH5_A Tight junction protein ZO-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 71.5 47.1 Yes Yes
2 empty 2.3 67.3 14.9 No No
3 empty 1.99 60.1 19.7 No No
4 empty 2.3 60.6 15.9 No No
5 empty 2.23 65.6 17.2 No No
6 empty 1.89 60.8 16 No No
7 empty 2.44 61.5 20.8 No No
8 empty 2.6 59.7 19.7 No No
9 empty 1.98 80.1 11.5 No No
10 empty 2 69 7.7 No No
4OEO_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.26 70.3 15.4 No No
2 bound 1.87 62.7 16.7 No No
3 empty 2.57 68.5 14.1 No No
4 empty 2.05 48.3 9.2 No No
5 empty 2.55 69.2 7.1 No No
6 empty 1.58 65.8 5.1 No No
7 empty 2.25 65.7 7.1 No No
8 empty 2.3 71.9 6.5 No No
9 empty .12 97.8 0 Yes No
10 empty 2.4 64.6 5.5 No No
3TSW_B Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.23 65.7 33.5 Yes No
2 empty 2.26 65.5 29.7 No No
3 empty 2.11 60.7 19.3 No No
4 empty 2.33 63.4 18.3 No No
5 empty 2.42 54.1 17.9 No No
6 empty 1.95 64.9 19.3 No No
7 empty 2.09 74.3 10.6 No No
8 empty 2.12 62.9 16.2 No No
9 empty 2.17 58.6 9.7 No No
10 empty 2.27 63.3 10.7 No No
4OEO_C Tight junction protein ZO-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.38 70.3 14.1 No No
2 empty 1.87 64.7 16 No No
3 empty 2.84 59.9 16.8 No No
4 empty 2.61 68.2 10.1 No No
5 empty 2.15 47.2 8.7 No No
6 empty 1.61 66.7 5.9 No No
7 empty 2.07 72 0 No No
8 empty 2.29 64.1 5.4 No No
9 empty 2.43 62.7 5 No No
10 empty 2.4 66.2 4.6 No No
2KXS_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 64.3 34.2 Yes No
2 empty 2.49 62.2 22.4 No No
3 empty 2.07 65.6 13.1 No No
4 empty 2.54 69.4 13.3 No No
5 empty 2.91 65.2 13.7 No No
6 empty 2.22 66.5 10 No No
7 empty 2.29 63.6 8.8 No No
8 empty 2.66 65.3 7.6 No No
9 empty 1.88 69.7 7.8 No No
10 empty 2.81 59.8 7.3 No No
4YYX_B Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.52 62.3 33.4 Yes No
2 empty 2.46 69.6 15 No No
3 empty 2.02 66.9 16.1 No No
4 empty 2.42 51.8 9.8 No No
5 empty 2.05 51.2 9.1 No No
6 empty 2.05 60.1 10.3 No No
7 empty 2.63 61.3 7.7 No No
8 empty 2.46 51.8 6.2 No No
9 bound 2.38 80.8 0 No No
10 empty 2.61 79.6 0 No No
2RCZ_A Tight junction protein ZO-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 66.6 29.7 Yes Yes
2 empty 2.64 60.4 16.2 No No
3 empty 2.54 53.8 17.3 No No
4 empty 1.8 46.4 10.6 No No
5 empty 2.79 60.1 9 No No
6 empty 2.22 58.2 11.2 No No
7 empty 2.45 72.9 6.9 No No
8 empty 2.23 48.5 8.9 No No
9 empty 2.84 65.2 5.7 No No
10 empty 3.09 42.4 7.9 No No
2KXR_A Tight junction protein ZO-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.47 58.8 16.4 No No
2 empty 2.3 67.5 19.5 No No
3 empty 2.39 64.5 11.1 No No
4 empty 1.89 65 8.9 No No
5 empty 1.78 56.3 11.6 No No
6 empty 2.71 69.3 9.3 No No
7 empty 2.53 66.1 7.9 No No
8 empty 2.97 62 10.6 No No
9 empty 2.06 61 9.5 No No
10 empty 2.19 67.7 8.4 No No
3TSZ_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 65.3 56 Yes No
2 empty 2.07 75.9 27.3 No No
3 empty 2.21 67.8 36.1 No No
4 empty 2.47 63.9 18.3 No No
5 empty 2 58.8 19.2 No No
6 empty 2.45 67.1 16.6 No No
7 empty 2.49 56.2 15.1 No No
8 empty 2.02 60.7 16.3 No No
9 empty 2.1 55.4 14.5 No No
10 empty 2.41 72.6 10.1 No No
2JWE_B Tight junction protein ZO-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 68.6 30.1 Yes Yes
2 empty 2.57 55 19.2 No No
3 empty 2.84 59.3 18.3 No No
4 empty 1.9 48.4 13.7 No No
5 empty 2.5 60.4 19.6 No No
6 empty 1.9 55.9 14.9 No No
7 empty 2.74 58.9 12.2 No No
8 empty 2.76 52.6 11.3 No No
9 empty 2.29 47.1 13.6 No No
10 empty 2.7 56.3 7.7 No No
3CYY_A Tight junction protein ZO-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 67.1 29.6 Yes Yes
2 empty 3.03 60.3 18.4 No No
3 empty 2.5 51.7 15.8 No No
4 empty 2.04 44.4 12.4 No No
5 empty 2.69 49.5 9.8 No No
6 empty 2.18 67.9 8.8 No No
7 empty 2.92 72.5 5.6 No No
8 empty 2.3 50.4 8.3 No No
9 empty 3.14 77.5 0 No No
10 empty 2.95 69.5 4.8 No No
3TSV_A Tight junction protein ZO-1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.2 63.5 23.8 No No
2 empty 2.19 61 11.7 No No
3 empty 2.53 58.1 15 No No
4 empty 1.97 61.8 9.4 No No
5 empty 2.68 52.7 12 No No
6 empty 1.83 66.8 7.2 No No
7 empty 2.16 62.3 9.1 No No
8 empty 2.69 58.8 9.1 No No
9 empty 2.27 51 7.6 No No
10 empty 2.39 61.3 7.3 No No
4OEO_B Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.25 64.5 22.4 No No
2 bound 1.98 64.5 18.1 No No
3 empty 2.3 61.3 10.8 No No
4 empty 2.6 59 7.4 No No
5 empty 2.93 56.8 5.5 No No
6 empty 1.6 70.7 5.1 No No
7 empty .08 100 0 Yes No
8 empty 2.33 72.4 5.9 No No
9 empty 2.22 62.2 5.7 No No
10 empty 2.59 62.5 5.8 No No
3TSW_A Tight junction protein ZO-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 66 46.4 Yes No
2 empty 2.04 65.7 43.6 No No
3 empty 2.21 66 42.5 No No
4 empty 2.69 63.9 27.2 No No
5 empty 2.07 62.4 17.9 No No
6 empty 1.75 67.9 14.1 No No
7 empty 2.43 54.8 13.2 No No
8 empty 2.24 61.7 10.9 No No
9 empty 2.42 71.2 10.2 No No
10 empty 2.34 58.6 14.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed18
Domains assessed as druggable using the strict criteria6
Domains assessed as druggable using the relaxed criteria11

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2H2B_A (3100650) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, UNMATCHED 1.6Å Yes Yes
2H2C_A (3100651) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, UNMATCHED 2Å Yes Yes
2H3M_A (3100697) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, UNMATCHED 2.8Å Yes No
2JWE_A (3140197) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, UNMATCHED Yes No
2JWE_A (4024847) Tight junction protein ZO-1 UNMATCHED, UNMATCHED, UNMATCHED 2JWE HOMO Yes No
2JWE_B (4024847) Tight junction protein ZO-1 UNMATCHED, UNMATCHED, UNMATCHED 2JWE HOMO Yes No
2KXR_A (3570924) Tight junction protein ZO-1 PFAM, PFAM, PFAM ZU5 No No
2KXS_A (3570925) Tight junction protein ZO-1 PFAM, PFAM, PFAM ZU5 Yes No
2RCZ_A (3200477) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, PDZ domain 1.7Å Yes No
2RCZ_A (4040568) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, PDZ domain (Homo Multimer) 1.7Å No No
2RCZ_B (4040568) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, PDZ domain (Homo Multimer) 1.7Å No No
3CYY_A (3350260) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, UNMATCHED 2.4Å Yes Yes
3LH5_A (3530249) Tight junction protein ZO-1 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 2.6Å Yes Yes
3LH5_A (3530248) Tight junction protein ZO-1 PFAM, PFAM, PFAM SH3_2 2.6Å No No
3SHU_A (3710150) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, UNMATCHED 2.75Å No No
3SHW_A (3710152) Tight junction protein ZO-1 PFAM, PFAM, PFAM SH3_2 2.9Å No No
3SHW_A (3710154) Tight junction protein ZO-1 P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 2.9Å Yes Yes
3SHW_A (3710151) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, UNMATCHED 2.9Å No No
3TSV_A (4014993) Tight junction protein ZO-1 PDZ domain-like, PDZ domain-like, PDZ domain 1.989Å No No
3TSW_B (4009151) Tight junction protein ZO-1 UNMATCHED, UNMATCHED, UNMATCHED 3TSW HOMO 2.83Å Yes Yes
3TSW_C (4009151) Tight junction protein ZO-1 UNMATCHED, UNMATCHED, UNMATCHED 3TSW HOMO 2.83Å Yes Yes
3TSW_D (4009151) Tight junction protein ZO-1 UNMATCHED, UNMATCHED, UNMATCHED 3TSW HOMO 2.83Å Yes Yes
3TSW_A (4009151) Tight junction protein ZO-1 UNMATCHED, UNMATCHED, UNMATCHED 3TSW HOMO 2.83Å Yes Yes
Ligand-based Druggability Score: 1.15
Ligand-based Druggability Score Percentile: 92%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


TJP1 is involved in 39 interactions in the network.


Druggability
Overall Druggability Percentile: 96.61
Druggability for Cancer Therapeutics: 81.18
Druggability for Other Therapeutics: 97.20
Cancer-Associated
Cancer-associated percentile : 81.36
Network Articulation Point
Is TJP1 critical for communication in the network?


Detailed Graph Legend:Help