Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDK18 (Q07002) - Overview - Molecular Target Synopsis

Protein


CDK18, Cyclin-dependent kinase 18
Enzyme Classification 2.7.11.22
UniProt Q07002

Also Known as CDK18_HUMAN, CDK18, PCTAIRE3, PCTK3

May play a role in signal transduction cascades in terminally differentiated cells.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: CDK18 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDK18 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-475, NCI-H2596, COV318

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, SK-N-SH, NHLF

(see details)

RNA Interference


CDK18 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCC38, SUM44. (see details)

3D Structures


At greater than 75% identity similarity to CDK18 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDK18 has been screened with 138 compounds (217 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (10 bioactivities). (see details)