Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CDK18 (Q07002) - Overview - Molecular Target Synopsis


CDK18, Cyclin-dependent kinase 18
Enzyme Classification
UniProt Q07002

Also Known as CDK18_HUMAN, CDK18, PCTAIRE3, PCTK3

May play a role in signal transduction cascades in terminally differentiated cells.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: CDK18 is active in the following subcellular-locations: cytoplasm, nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CDK18 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-475, NCI-H2596, COV318

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, SK-N-SH, NHLF

(see details)

RNA Interference

CDK18 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCC38, SUM44. (see details)

3D Structures

At greater than 75% identity similarity to CDK18 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CDK18 has been screened with 138 compounds (217 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (10 bioactivities). (see details)