Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

lecA (Q05097) - Overview - Molecular Target Synopsis

Protein


lecA, PA-I galactophilic lectin
UniProt Q05097

Also Known as PA1L_PSEAE, lecA, pa1L

D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl-beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity.

5MIH
CRYSTAL STRUCTURE OF THE LECTIN LECA FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH A PHENYL-EPOXY-GALACTOPYRANOSIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for lecA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
122Q05097-1

Sub-cellular localization


UniProt: lecA is active in the following subcellular-locations: cell surface, cytoplasm, periplasm.
GO terms: lecA is active in the following subcellular-locations: cell surface, cytoplasm, periplasmic space.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project lecA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For lecA there are:
23 structures (137 chains) solved
21 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

lecA is solved in complex with the approved drug(s):

BGC/DEXTROSE (2VXJ_A, 2VXJ_B, 2VXJ_D, 2VXJ_F, 2VXJ_G, 2VXJ_H, 2VXJ_I, 2VXJ_J, 2VXJ_K, 2VXJ_L, 2VXJ_M, 2VXJ_N, 2VXJ_O, 2VXJ_P, 2VXJ_Q, 2VXJ_R, 2VXJ_S, 2VXJ_T).

(see details)
Molecular Target 3D Synopsis