Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MST1R (Q04912) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 02/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 02/07/2019)


Chains assessed4
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria4


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4FWW_A Macrophage-stimulating protein receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2 78.1 18.6 Yes No
2 empty 2.09 63.5 24.9 No No
3 empty 2.21 69 26.9 No No
4 bound 2.01 56.5 23.2 No No
5 empty 1.79 54.9 23.2 No No
6 empty 1.87 70.1 13.5 No No
7 empty 1.75 65.1 15.4 No No
8 empty 2.26 57.3 18.8 No No
9 empty 1.8 60.9 18.7 No No
10 empty 2.18 57.5 15.5 No No
3PLS_A Macrophage-stimulating protein receptor Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 68.1 38 Yes No
2 empty 2.42 64.8 37.8 No No
3 empty 2.38 66.3 26.7 No No
4 empty 2.33 65.7 19.3 No No
5 empty 1.87 71.2 17.8 No No
6 empty 2.19 68.4 14.3 No No
7 empty 1.85 62.9 21.1 No No
8 empty 2.33 64.3 11.6 No No
9 empty 1.88 62.3 12.6 No No
10 empty 2.13 63.7 14.6 No No
4QT8_A Macrophage-stimulating protein receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.87 67.5 47.9 Yes Yes
2 empty 1.97 76.3 28.3 No No
3 empty 2.22 62.6 35.9 No No
4 empty 1.93 73.1 24.3 No No
5 empty 2.25 65.4 26.5 No No
6 bound 2.27 66.1 32.2 No No
7 empty 2.09 59.2 24.7 No No
8 empty 1.97 67.9 20.3 No No
9 empty 1.88 61.8 20.2 No No
10 empty 1.85 64.2 24.5 No No
4QT8_B Macrophage-stimulating protein receptor Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 67.2 55.5 Yes Yes
2 empty 1.96 66.8 39 No No
3 empty 2.08 77.1 30.2 No No
4 empty 1.7 67.3 40.6 No No
5 empty 1.78 64.2 30.7 No No
6 empty 1.97 62.7 22.8 No No
7 empty 2.03 66.6 19.8 No No
8 empty 2.06 64.9 24.7 No No
9 bound 1.77 65.8 24.5 No No
10 empty 1.78 57.9 16.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed1
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria1

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3PLS_A (3670358) Macrophage-stimulating protein receptor Protein kinase-like (PK-like), Protein kinase-like (PK-like), UNMATCHED 2.24Å Yes No
Ligand-based Druggability Score: 0.05
Ligand-based Druggability Score Percentile: 80%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MST1R is involved in 27 interactions in the network.


Druggability
Overall Druggability Percentile: 98.20
Druggability for Cancer Therapeutics: 98.37
Druggability for Other Therapeutics: 86.76
Cancer-Associated
Cancer-associated percentile : 98.27
Network Articulation Point
Is MST1R critical for communication in the network?


Detailed Graph Legend:Help