Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations

GLO1 (Q04760) - Overview - Molecular Target Synopsis

Protein


GLO1, Lactoylglutathione lyase
Enzyme Classification 4.4.1.5
UniProt Q04760

Also Known as LGUL_HUMAN, GLO1

Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. Homodimer.

3W0T deposition date (02-NOV-12)
HUMAN GLYOXALASE I WITH AN N-HYDROXYPYRIDONE DERIVATIVE INHIBITOR
RCSB/PDB
Inspect Structure
See all 3D Structures for GLO1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
184ENSG00000124767ENST00000373365ENSP00000362463Q04760-1
169Q04760-2

Sub-cellular localization


GO terms: GLO1 is active in the following subcellular-locations: cytoplasm, cytosol, extracellular exosome, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GLO1 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, COLO205, MDA_MB_231

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC4011, MG-63, COLO 206F

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, NHEK, HMEC

(see details)

RNA Interference


GLO1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

3D Structures


There are 7 structures (22 chains) solved for GLO1
7 are solved in complex with at least one small molecule ligand

GLO1 is solved in complex with the approved drug(s):

IMN/ (4KYK_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GLO1 has been screened with 144 compounds (211 bioactivities), 29 compounds have bioactivities that show binding affinity of <= 500nM (32 bioactivities). (see details)