Molecular Target Synopsis
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RRN11 (Q04712) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed15
Chains with at least one site assessed as druggable using the strict criteria2
Chains with at least one site assessed as druggable using the relaxed criteria15


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5O7X_L RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.05 64.9 71.5 Yes No
2 empty 1.68 74.5 17 Yes No
3 empty 2.17 60.8 20.5 No No
4 empty 1.61 63.9 14.5 No No
5 empty 2.03 63.9 15.7 No No
6 empty 1.97 62 16.5 No No
7 empty 2.37 62.2 15.4 No No
8 empty 1.9 22.7 18.8 No No
9 empty 1.79 81.9 10.9 No No
10 empty 2.16 44.8 12.9 No No
5O7X_I RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 65.5 71.4 Yes No
2 empty 1.65 74.3 17.5 Yes No
3 empty 2.18 59.4 19.5 No No
4 empty 1.59 68.2 10.6 No No
5 empty 2.1 63.8 12.1 No No
6 empty 2.39 58.2 16.2 No No
7 empty 1.81 26.6 18.6 No No
8 empty 2.1 64.2 11 No No
9 empty 2.35 45.1 13.8 No No
10 empty 3.2 50.9 12.7 No No
5W64_Q RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 65.4 51.1 Yes No
2 empty 2.02 64.5 47.6 No No
3 empty 1.8 61.4 26.3 No No
4 empty 2.18 63.6 33.6 No No
5 empty 1.86 67.9 27.3 No No
6 empty 2.08 62.7 23.1 No No
7 empty 1.88 61.3 17.6 No No
8 empty 2.31 86.1 16.7 Yes No
9 empty 2.1 56.9 18.6 No No
10 empty 2.14 63 20.1 No No
5W65_Q RNA polymerase I-specific transcription initiation factor RRN11 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2 67.3 40.2 Yes Yes
2 empty 2.02 69.5 32.1 No No
3 empty 1.68 62.7 25.8 No No
4 empty 1.87 63 35.4 No No
5 empty 1.89 66.3 26.2 No No
6 empty 1.9 64.5 31.2 No No
7 empty 2.28 61.8 18.6 No No
8 empty 2.34 65.5 26.4 No No
9 empty 1.87 66 23.5 No No
10 empty 2.1 59.3 21 No No
5N61_R RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.09 65.7 75.7 Yes No
2 empty 2.27 60.3 18.2 No No
3 empty 1.99 25.9 19.2 No No
4 empty 2.19 60.3 15.7 No No
5 empty 1.96 66.9 12.2 No No
6 empty 1.8 66.6 11.4 No No
7 empty 2.14 64.9 10 No No
8 empty 1.82 80.4 10 No No
9 empty 2.61 58.7 8.6 No No
10 empty 2.29 45.5 12.3 No No
5O7X_C RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 64.9 70.3 Yes No
2 empty 1.69 74 15.8 Yes No
3 empty 2.11 58.9 19.1 No No
4 empty 1.77 74.7 14.5 No No
5 empty 2.04 63 15.1 No No
6 empty 1.62 66.6 15 No No
7 empty 1.94 68.1 13.6 No No
8 empty 2.28 57.5 15.9 No No
9 empty 1.79 24.2 18.6 No No
10 empty 2.23 44.7 11.9 No No
5W66_Q RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 65.7 54.8 Yes No
2 empty 1.9 65 35 No No
3 empty 1.9 65.6 27.8 No No
4 empty 1.94 63.5 31.1 No No
5 empty 2.51 65.8 20.7 No No
6 empty 2.2 60.5 18.6 No No
7 empty 2.12 60.3 21.1 No No
8 empty 1.83 68.4 17.1 No No
9 empty 2.15 86.8 16.1 Yes No
10 empty 2.39 57.5 15.1 No No
5N5Z_R RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 62.4 81.3 Yes No
2 empty 2.07 75.5 41.5 No No
3 empty 2.31 63 17.8 No No
4 empty 1.74 71.3 14.4 No No
5 empty 1.83 66.5 14.1 No No
6 empty 2.02 62.6 17 No No
7 empty 2.35 59.8 13.9 No No
8 empty 2.33 45.8 13.3 No No
9 empty 2.38 71.3 11.2 No No
10 empty 2.02 66.7 7.3 No No
5W5Y_Q RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 65.6 52.9 Yes No
2 empty 1.57 65.3 23.1 No No
3 empty 1.89 67.5 27.6 No No
4 empty 1.97 64.8 20.2 No No
5 empty 1.87 61.3 18.2 No No
6 empty 2.26 60.2 18.6 No No
7 empty 1.92 66.4 23.2 No No
8 empty 2.32 85.2 16 Yes No
9 empty 2.62 66.9 17.8 No No
10 empty 1.94 58.1 15.6 No No
5N5Y_R RNA polymerase I-specific transcription initiation factor RRN11 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.54 67.1 76.8 Yes Yes
2 empty 2.29 60.4 25.2 No No
3 empty 2.21 64.6 17.6 No No
4 empty 1.76 70.1 14 No No
5 empty 1.84 65.5 12.8 No No
6 empty 1.71 72.2 14.5 No No
7 empty 2.05 66.8 12.6 No No
8 empty 2.13 23.8 18.9 No No
9 empty 2.28 59.9 16 No No
10 empty 2.3 43.3 14 No No
5OA1_W RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 59.2 65.2 Yes No
2 empty 3.12 60.4 5.5 No No
3 empty 2.06 73.6 0 No No
4 empty 2.42 51.2 5.7 No No
5O7X_R RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 65.7 72 Yes No
2 empty 2.46 64.4 41.5 No No
3 empty 1.67 73.7 18.8 No No
4 empty 2.2 58.9 19.7 No No
5 empty 1.96 67.5 13.3 No No
6 empty 1.68 65 13.2 No No
7 empty 2.3 59.5 15.4 No No
8 empty 1.93 62.3 11.7 No No
9 empty 2.05 17.8 18.6 No No
10 empty 1.75 79.6 10.6 No No
5O7X_O RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.97 65.5 74.6 Yes No
2 empty 1.67 73.7 15.2 Yes No
3 empty 2.19 59 18.5 No No
4 empty 2.03 63 17.2 No No
5 empty 1.58 66.7 15.1 No No
6 empty 2.01 65.9 12.6 No No
7 empty 2.35 59.4 15.4 No No
8 empty 2.01 21.9 18.3 No No
9 empty 2.11 66.3 7.6 No No
10 empty 2.37 44.9 12.4 No No
5N60_R RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.13 65.8 77.6 Yes No
2 empty 1.75 78.3 18.3 No No
3 empty 2.12 71.5 16.5 No No
4 empty 2.27 65.1 17 No No
5 empty 2.06 78.4 14.6 No No
6 empty 1.76 69.1 15.2 No No
7 empty 2.54 54.3 12.1 No No
8 empty 2.35 48.6 11.3 No No
9 empty 2.04 65.6 7.9 No No
10 empty 2.38 43.3 13.2 No No
5O7X_F RNA polymerase I-specific transcription initiation factor RRN11 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.96 64.7 75.3 Yes No
2 empty 1.67 73.4 18.9 Yes No
3 empty 2.16 63.5 17.8 No No
4 empty 1.77 70.9 15.2 No No
5 empty 1.83 62.9 18 No No
6 empty 1.63 68.4 10.9 No No
7 empty 1.88 65.7 14.1 No No
8 empty 2.36 55.2 15.3 No No
9 empty 1.8 24.1 18.5 No No
10 empty 1.8 81.9 9.9 No No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score