Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
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RRN11 (Q04712) - Overview - Molecular Target Synopsis

Protein


RRN11, RNA polymerase I-specific transcription initiation factor RRN11
UniProt Q04712

Also Known as RRN11_YEAST, RRN11

Acts as component of the core factor (CF) complex which is essential for the initiation of rDNA transcription by RNA polymerase I. After binding of UAF (upstream activation factor) to an upstream element of the promoter, CF is recruited in a SPT15/TBP-dependent manner to form a preinitiation complex. Component of the core factor (CF) complex, which consists of RRN6, RRN7 and RRN11. The CF heterotrimer may further dimerize to form a hexamer. RRN11 interacts with RRN6, RRN7 and SPT15.

5O7X
CRYSTAL STRUCTURE OF S. CEREVISIAE CORE FACTOR AT 3.2A RESOLUTION
RCSB/PDB
Inspect Structure
See all 3D Structures for RRN11

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
507Q04712-1

Sub-cellular localization


UniProt: RRN11 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: RRN11 is active in the following subcellular-locations: nucleolus, RNA polymerase I core factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RRN11 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For RRN11 there are:
10 structures (15 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis