Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Fnta (Q04631) - Overview - Molecular Target Synopsis

Protein


Fnta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Enzyme Classification 2.5.1.58
UniProt Q04631

Also Known as FNTA_RAT, Fnta

Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. Interacts with MUSK; the interaction is direct and mediates AGRIN-induced phosphorylation of FNTA (By similarity). Heterodimer of FNTA and FNTB (farnesyltransferase). Heterodimer of FNTA and PGGT1B (geranylgeranyltransferase).

4GTO
FTASE IN COMPLEX WITH BMS ANALOGUE 14
RCSB/PDB
Inspect Structure
See all 3D Structures for Fnta

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
377Q04631-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project Fnta has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Fnta there are:
52 structures (102 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Fnta has been screened with 423 compounds (527 bioactivities), 206 compounds have bioactivities that show binding affinity of <= 500nM (251 bioactivities). (see details)