Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TAP1 (Q03518) - Overview - Molecular Target Synopsis

Protein


TAP1, Antigen peptide transporter 1
UniProt Q03518

Also Known as TAP1_HUMAN, TAP1, ABCB2, PSF1, RING4, Y3

Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules. Heterodimer of TAP1 and TAP2. Interacts with PSMB5 and PSMB8 (PubMed:15488952). Similarly to classical MHC class I assembly, HLA-E-B2M complex binds TAP1-TAP2 heterodimer and CALR before the peptide loading (PubMed:9427624). Interacts with HLA-F.

5U1D
CRYO-EM STRUCTURE OF THE HUMAN TAP ATP-BINDING CASSETTE TRANSPORTER
RCSB/PDB
Inspect Structure
See all 3D Structures for TAP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
808ENSG00000168394ENST00000354258ENSP00000346206Q03518-1

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project TAP1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, NCI_H226, HT29

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: M059J, SW 1990, NCI-H596

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, BJ

(see details)

3D Structures


For TAP1 there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TAP1 has been screened with compounds ( bioactivities). (see details)