Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MVK (Q03426) - Overview - Molecular Target Synopsis

Protein


MVK, Mevalonate kinase
Enzyme Classification 2.7.1.36
UniProt Q03426

Also Known as KIME_HUMAN, MVK

Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis (PubMed:9325256, PubMed:18302342). Homodimer.

2R3V
THE BIOCHEMICAL AND STRUCTURAL BASIS FOR FEEDBACK INHIBITION OF MEVALONATE KINASE AND ISOPRENOID METABOLISM
RCSB/PDB
Inspect Structure
See all 3D Structures for MVK

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MVK is active in the following subcellular-locations: cytoplasm, peroxisome.
GO terms: MVK is active in the following subcellular-locations: cytosol, peroxisome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MVK has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: KM12, T47D, HCC_2998

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: BHY, LCLC-103H, SK-N-AS

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HMEC, HUVEC

(see details)

RNA Interference


MVK was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HS578T, SKGT4. (see details)

3D Structures


For MVK there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MVK has been screened with compounds ( bioactivities). (see details)