Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GSTM4 (Q03013) - Overview - Molecular Target Synopsis

Protein


GSTM4, Glutathione S-transferase Mu 4
Enzyme Classification 2.5.1.18
UniProt Q03013

Also Known as GSTM4_HUMAN, GSTM4

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Active on 1-chloro-2,4-dinitrobenzene. Homodimer.

4GTU
LIGAND-FREE HOMODIMERIC HUMAN GLUTATHIONE S-TRANSFERASE M4-4
RCSB/PDB
Inspect Structure
See all 3D Structures for GSTM4

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GSTM4 is active in the following subcellular-locations: cytoplasm.
GO terms: GSTM4 is active in the following subcellular-locations: cytoplasm, cytosol, intercellular bridge.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GSTM4 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: U251, SNB_19, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SW 1573, AGS, A-673

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, SK-N-SH, IMR-90

(see details)

3D Structures


For GSTM4 there are:
1 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GSTM4 has been screened with 1 compounds (1 bioactivities). (see details)