Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GUCY2D (Q02846) - Overview - Molecular Target Synopsis

Protein


GUCY2D, Retinal guanylyl cyclase 1
Enzyme Classification 4.6.1.2
UniProt Q02846

Also Known as GUC2D_HUMAN, GUCY2D, CORD6, GUC1A4, GUC2D, RETGC, RETGC1

Probably plays a specific functional role in the rods and/or cones of photoreceptors. It may be the enzyme involved in the resynthesis of cGMP required for recovery of the dark state after phototransduction.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1103ENSG00000132518ENST00000254854ENSP00000254854Q02846-1

Sub-cellular localization


UniProt: GUCY2D is active in the following subcellular-locations: membrane.
GO terms: GUCY2D is active in the following subcellular-locations: integral component of plasma membrane, nuclear outer membrane, photoreceptor disc membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GUCY2D has gain in 0 cell-lines, loss in 7 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, SK_MEL_5, NCI_H522

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H82, Hs 746T, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


GUCY2D was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: KPD, G292. (see details)

3D Structures


At greater than 35% identity similarity to GUCY2D there are:
17 structures (64 chains) solved
7 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GUCY2D has been screened with compounds ( bioactivities). (see details)