Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAP3K10 (Q02779) - Overview - Molecular Target Synopsis

Protein


MAP3K10, Mitogen-activated protein kinase kinase kinase 10
Enzyme Classification 2.7.11.25
UniProt Q02779

Also Known as M3K10_HUMAN, MAP3K10, MLK2, MST

Activates the JUN N-terminal pathway. Homodimer. Interacts with SH3RF2.

2RF0
CRYSTAL STRUCTURE OF HUMAN MIXED LINEAGE KINASE MAP3K10 SH3 DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for MAP3K10

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: MAP3K10 is active in the following subcellular-locations: cytoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MAP3K10 has gain in 13 cell-lines, loss in 1 cell-lines and no signal in 990 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_OV_3, TK_10, SN12C

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H820, NIH:OVCAR-3, PANC-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, NHLF

(see details)

RNA Interference


MAP3K10 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: DU4475, PCI30. (see details)

3D Structures


For MAP3K10 there are:
1 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MAP3K10 has been screened with 136 compounds (183 bioactivities), 15 compounds have bioactivities that show binding affinity of <= 500nM (20 bioactivities). (see details)