Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

petB (Q02761) - Overview - Molecular Target Synopsis

Protein


petB, Cytochrome b
UniProt Q02761

Also Known as CYB_RHOSH, petB, fbcB

Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. The main subunits of complex b-c1 are: cytochrome b, cytochrome c1 and the Rieske protein.

5KKZ
RHODOBACTER SPHAEROIDES BC1 WITH FAMOXADONE
RCSB/PDB
Inspect Structure
See all 3D Structures for petB

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
445Q02761-1

Sub-cellular localization


UniProt: petB is active in the following subcellular-locations: cell membrane.
GO terms: petB is active in the following subcellular-locations: integral component of membrane, mitochondrion, plasma membrane, respiratory chain complex III.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project petB has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For petB there are:
6 structures (30 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

petB is solved in complex with the approved drug(s):

ASC/ASCORBIC ACID (5KKZ_A, 5KKZ_E, 5KKZ_K, 5KKZ_O).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


petB has been screened with compounds ( bioactivities). (see details)