Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ULP1 (Q02724) - Overview - Molecular Target Synopsis

Protein


ULP1, Ubiquitin-like-specific protease 1
Enzyme Classification 3.4.22.68
UniProt Q02724

Also Known as ULP1_YEAST, ULP1

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SMT3 to its mature form and deconjugation of SMT3 from targeted proteins. Has an essential role in the G2/M phase of the cell cycle.

5H2W
17 RESIDUE FRAGMENT OF
UBIQUITIN-LIKE-SPECIFIC PROTEASE 1
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF THE KARYOPHERIN KAP60P BOUND TO THE SUMO PROTEASE ULP1P (150-340)
RCSB/PDB
Inspect Structure
See all 3D Structures for ULP1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
621Q02724-1

Sub-cellular localization


GO terms: ULP1 is active in the following subcellular-locations: nuclear envelope, nucleolus, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ULP1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For ULP1 there are:
7 structures (8 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis