Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CYP27A1 (Q02318) - Overview - Molecular Target Synopsis

Protein


CYP27A1, Sterol 26-hydroxylase, mitochondrial
Enzyme Classification 1.14.15.15
UniProt Q02318

Also Known as CP27A_HUMAN, CYP27A1, CYP27

Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CYP27A1 is active in the following subcellular-locations: mitochondrion membrane.
GO terms: CYP27A1 is active in the following subcellular-locations: mitochondrial matrix, mitochondrial membrane, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CYP27A1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: COLO205, SK_MEL_28, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 792, HT-144, Hep G2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, BJ, CD14-positive monocyte

(see details)

RNA Interference


CYP27A1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)


Screening and Chemistry


CYP27A1 has been screened with 7 compounds (7 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)