Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CYP27A1 (Q02318) - Overview - Molecular Target Synopsis


CYP27A1, Sterol 26-hydroxylase, mitochondrial
Enzyme Classification
UniProt Q02318

Also Known as CP27A_HUMAN, CYP27A1, CYP27

Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3-25-hydroxylase activity.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: CYP27A1 is active in the following subcellular-locations: mitochondrion membrane.
GO terms: CYP27A1 is active in the following subcellular-locations: mitochondrial matrix, mitochondrial membrane, mitochondrion.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CYP27A1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: COLO205, SK_MEL_28, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COLO 792, HT-144, Hep G2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, BJ, CD14-positive monocyte

(see details)

RNA Interference

CYP27A1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: . (see details)

Screening and Chemistry

CYP27A1 has been screened with 7 compounds (7 bioactivities), 1 compounds have bioactivities that show binding affinity of <= 500nM (1 bioactivities). (see details)