Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

Fntb (Q02293) - Overview - Molecular Target Synopsis

Protein


Fntb, Protein farnesyltransferase subunit beta
Enzyme Classification 2.5.1.58
UniProt Q02293

Also Known as FNTB_RAT, Fntb

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Heterodimer of FNTA and FNTB.

4GTO
FTASE IN COMPLEX WITH BMS ANALOGUE 14
RCSB/PDB
Inspect Structure
See all 3D Structures for Fntb

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
437Q02293-1

Sub-cellular localization


GO terms: Fntb is active in the following subcellular-locations: protein farnesyltransferase complex, protein-containing complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project Fntb has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For Fntb there are:
42 structures (42 chains) solved
39 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


Fntb has been screened with 389 compounds (437 bioactivities), 203 compounds have bioactivities that show binding affinity of <= 500nM (226 bioactivities). (see details)