Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GUCY1A1 (Q02108) - Overview - Molecular Target Synopsis

Protein


GUCY1A1, Guanylate cyclase soluble subunit alpha-1
Enzyme Classification 4.6.1.2
UniProt Q02108

Also Known as GCYA1_HUMAN, GUCY1A1, GUC1A3, GUCSA3, GUCY1A3

The active enzyme is formed by a heterodimer of an alpha and a beta subunit. Heterodimer with GUCY1B1 (PubMed:9742212, PubMed:23505436, PubMed:24669844).

4NI2
CRYSTAL STRUCTURE OF THE HETERODIMERIC CATALYTIC DOMAIN OF WILD-TYPE HUMAN SOLUBLE GUANYLATE CYCLASE
RCSB/PDB
Inspect Structure
See all 3D Structures for GUCY1A1

Isoforms / Transcripts (Protein Coding)


Drugs


GUCY1A1 is targeted by Approved Drugs Riociguat, Isosorbide Dinitrate. (see details)
Riociguat
Isosorbide Dinitrate

Sub-cellular localization


UniProt: GUCY1A1 is active in the following subcellular-locations: cytoplasm.
GO terms: GUCY1A1 is active in the following subcellular-locations: GABA-ergic synapse, glutamatergic synapse, guanylate cyclase complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GUCY1A1 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

3D Structures


For GUCY1A1 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


GUCY1A1 has been screened with 148 compounds (212 bioactivities), 23 compounds have bioactivities that show binding affinity of <= 500nM (28 bioactivities). (see details)