Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ROR2 (Q01974) - Overview - Molecular Target Synopsis

Protein


ROR2, Tyrosine-protein kinase transmembrane receptor ROR2
Enzyme Classification 2.7.10.1
UniProt Q01974

Also Known as ROR2_HUMAN, ROR2, NTRKR2

Tyrosine-protein kinase receptor which may be involved in the early formation of the chondrocytes. It seems to be required for cartilage and growth plate development (By similarity). Phosphorylates YWHAB, leading to induction of osteogenesis and bone formation (PubMed:17717073). In contrast, has also been shown to have very little tyrosine kinase activity in vitro. May act as a receptor for wnt ligand WNT5A which may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443). Homodimer; promotes osteogenesis. Binds YWHAB (PubMed:17717073). Interacts with WTIP.

4GT4
STRUCTURE OF UNLIGANDED, INACTIVE ROR2 KINASE DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for ROR2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
943ENSG00000169071ENST00000375708ENSP00000364860Q01974-1
704ENSG00000169071ENST00000375715ENSP00000364867

Sub-cellular localization


UniProt: ROR2 is active in the following subcellular-locations: cell membrane.
GO terms: ROR2 is active in the following subcellular-locations: axon, cell surface, clathrin-coated endocytic vesicle membrane, dendrite, integral component of plasma membrane, microtubule, neuronal cell body, plasma membrane, receptor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ROR2 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, K_562, HCT_116

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, NCI-H1155, MHH-NB-11

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HFDPC, SK-N-SH, HSMM

(see details)

RNA Interference


ROR2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: CAMA1, SUM149. (see details)

3D Structures


For ROR2 there are:
2 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ROR2 has been screened with compounds ( bioactivities). (see details)