Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ROR1 (Q01973) - Overview - Molecular Target Synopsis

Protein


ROR1, Inactive tyrosine-protein kinase transmembrane receptor ROR1
UniProt Q01973

Also Known as ROR1_HUMAN, ROR1, NTRKR1

Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443). Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350). In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).

6BA5
POTENT AND SELECTIVE ANTITUMOR ACTIVITY OF A T-CELL ENGAGING BISPECIFIC ANTIBODY TARGETING A MEMBRANE-PROXIMAL EPITOPE OF ROR1
RCSB/PDB
Inspect Structure
See all 3D Structures for ROR1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ROR1 is active in the following subcellular-locations: axon, cell projection, membrane.
GO terms: ROR1 is active in the following subcellular-locations: axon, axon terminus, cell surface, cytoplasm, integral component of plasma membrane, plasma membrane, receptor complex, stress fiber.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ROR1 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, TK_10, 786_0

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, AGS, PA-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHLF, HMEC

(see details)

RNA Interference


ROR1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: G292, CAL120. (see details)

3D Structures


For ROR1 there are:
3 structures (9 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ROR1 has been screened with compounds ( bioactivities). (see details)