Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EWSR1 (Q01844) - Overview - Molecular Target Synopsis

Protein


EWSR1, RNA-binding protein EWS
UniProt Q01844

Also Known as EWS_HUMAN, EWSR1, EWS

Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes. Binds POLR2C, SF1, calmodulin and RNA. Interacts with PTK2B/FAK2 and TDRD3. Binds calmodulin in the presence, but not in the absence, of calcium ion.

2CPE
SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OF EWING SARCOMA(EWS) PROTEIN
RCSB/PDB
Inspect Structure
See all 3D Structures for EWSR1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: EWSR1 is active in the following subcellular-locations: cell membrane, cytoplasm, nucleus.
GO terms: EWSR1 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleus, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EWSR1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, MCF7, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1155, LN-18, NCI-H209

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


For EWSR1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


EWSR1 has been screened with compounds ( bioactivities). (see details)