Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FLI1 (Q01543) - Overview - Molecular Target Synopsis

Protein


FLI1, Friend leukemia integration 1 transcription factor
UniProt Q01543

Also Known as FLI1_HUMAN, FLI1

Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'. Can form homodimers or heterodimers with ETV6/TEL1.

5JVT
CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF TRANSCRIPTION FACTOR FLI1 IN COMPLEX WITH AN 11-MER DNA GACCGGAAGTG
RCSB/PDB
Inspect Structure
See all 3D Structures for FLI1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: FLI1 is active in the following subcellular-locations: nucleus.
GO terms: FLI1 is active in the following subcellular-locations: cytosol, nuclear body, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FLI1 has gain in 1 cell-lines, loss in 9 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HL_60, NCI_H226, UO_31

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, UKE-1, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HUVEC, CD20-positive B cell, CD14-positive monocyte

(see details)

3D Structures


For FLI1 there are:
6 structures (14 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FLI1 has been screened with 12 compounds (13 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)