Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

FABP5 (Q01469) - Overview - Molecular Target Synopsis

Protein


FABP5, Fatty acid-binding protein 5
UniProt Q01469

Also Known as FABP5_HUMAN, FABP5

Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987). Monomer. Homodimer.

5UR9
ENANTIOMER-SPECIFIC BINDING OF THE POTENT ANTINOCICEPTIVE AGENT SBFI- 26 TO ANANDAMIDE TRANSPORTERS FABP5
RCSB/PDB
Inspect Structure
See all 3D Structures for FABP5

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
135ENSG00000164687ENST00000297258ENSP00000297258Q01469-1
101ENSG00000164687ENST00000396359ENSP00000379647

Sub-cellular localization


UniProt: FABP5 is active in the following subcellular-locations: cell junction, cytoplasm, nucleus, postsynaptic cell membrane, postsynaptic density, secreted, synapse.
GO terms: FABP5 is active in the following subcellular-locations: azurophil granule lumen, cell junction, cytoplasm, cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus, plasma membrane, postsynaptic density, postsynaptic membrane, secretory granule membrane, synapse.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project FABP5 has gain in 18 cell-lines, loss in 2 cell-lines and no signal in 985 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_5, SR, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OV-90, SR-786, GP2d

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, HMEC, A549

(see details)

3D Structures


For FABP5 there are:
8 structures (20 chains) solved
6 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

FABP5 is solved in complex with the approved drug(s):

TAR/TARTARIC ACID (4LKT_B, 4LKT_C, 4LKT_D).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


FABP5 has been screened with 155 compounds (160 bioactivities), 53 compounds have bioactivities that show binding affinity of <= 500nM (53 bioactivities). (see details)