Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

FABP5 (Q01469) - Overview - Molecular Target Synopsis


FABP5, Fatty acid-binding protein 5
UniProt Q01469

Also Known as FABP5_HUMAN, FABP5

Intracellular carrier for long-chain fatty acids and related active lipids, such as the endocannabinoid, that regulates the metabolism and actions of the ligands they bind. In addition to the cytosolic transport, selectively delivers specific fatty acids from the cytosol to the nucleus, wherein they activate nuclear receptors (PubMed:22170058). Delivers retinoic acid to the nuclear receptor peroxisome proliferator-activated receptor delta; which promotes proliferation and survival. May also serve as a synaptic carrier of endocannabinoid at central synapses and thus controls retrograde endocannabinoid signaling. Modulates inflammation by regulating PTGES induction via NF-kappa-B activation, and prostaglandin E2 (PGE2) biosynthesis during inflammation (By similarity). May be involved in keratinocyte differentiation (PubMed:8092987). Monomer. Homodimer.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: FABP5 is active in the following subcellular-locations: cell junction, cytoplasm, nucleus, postsynaptic cell membrane, postsynaptic density, secreted, synapse.
GO terms: FABP5 is active in the following subcellular-locations: azurophil granule lumen, cell junction, cytoplasm, cytosol, extracellular exosome, extracellular region, nucleoplasm, nucleus, plasma membrane, postsynaptic density, postsynaptic membrane, secretory granule membrane, synapse.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project FABP5 has gain in 18 cell-lines, loss in 2 cell-lines and no signal in 985 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, SR, UACC_62

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OV-90, SR-786, GP2d

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, HMEC, A549

(see details)

3D Structures

For FABP5 there are:
8 structures (20 chains) solved
6 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

FABP5 has been screened with 55 compounds (58 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (9 bioactivities). (see details)