Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AMPD2 (Q01433) - Overview - Molecular Target Synopsis

Protein


AMPD2, AMP deaminase 2
Enzyme Classification 3.5.4.6
UniProt Q01433

Also Known as AMPD2_HUMAN, AMPD2

AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. Homotetramer.

4NO5
9 RESIDUE FRAGMENT OF
AMP DEAMINASE 2
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF NON-PHOSPHORYLATED FORM OF AMPD2 PHOSPHOPEPTIDE BOUND TO HLA-A2
RCSB/PDB
Inspect Structure
See all 3D Structures for AMPD2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: AMPD2 is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AMPD2 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: 786_0, RXF_393, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, 786-O, COV318

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, IMR-90

(see details)

3D Structures


For AMPD2 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


AMPD2 has been screened with 42 compounds (43 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (3 bioactivities). (see details)