Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

AMPD3 (Q01432) - Overview - Molecular Target Synopsis


AMPD3, AMP deaminase 3
Enzyme Classification
UniProt Q01432

Also Known as AMPD3_HUMAN, AMPD3

AMP deaminase plays a critical role in energy metabolism. Homotetramer.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: AMPD3 is active in the following subcellular-locations: cytosol, extracellular region, ficolin-1-rich granule lumen, secretory granule lumen.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project AMPD3 has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SR, K_562, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Capan-2, DMS 53, CPC-N

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, NHLF, AG445

(see details)

3D Structures

At greater than 50% identity similarity to AMPD3 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

AMPD3 has been screened with 49 compounds (51 bioactivities), 22 compounds have bioactivities that show binding affinity of <= 500nM (24 bioactivities). (see details)