Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GALK2 (Q01415) - Overview - Molecular Target Synopsis

Protein


GALK2, N-acetylgalactosamine kinase
Enzyme Classification 2.7.1.157
UniProt Q01415

Also Known as GALK2_HUMAN, GALK2, GK2

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates. Monomer.

2A2C
X-RAY STRUCTURE OF HUMAN N-ACETYL GALACTOSAMINE KINASE COMPLEXED WITH MG-ADP AND N-ACETYL GALACTOSAMINE 1- PHOSPHATE
RCSB/PDB
Inspect Structure
See all 3D Structures for GALK2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: GALK2 is active in the following subcellular-locations: cytoplasm, cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GALK2 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, U251, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KPL-4, LS1034, COLO 205

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, K562, SK-N-SH

(see details)

RNA Interference


GALK2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: HCH1, JHESOAD1. (see details)

3D Structures


For GALK2 there are:
2 structures (2 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis