Molecular Target Synopsis
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RPA49 (Q01080) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 10/09/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 10/09/2019)


Chains assessed32
Chains with at least one site assessed as druggable using the strict criteria12
Chains with at least one site assessed as druggable using the relaxed criteria24


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
5W66_M DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.95 65.5 32.6 Yes No
2 empty 2.16 66 34.7 No No
3 empty 2.41 70.8 22.1 No No
4 empty 2.75 67.9 23 No No
5 empty 1.96 62.6 23.3 No No
6 empty 2.52 65 21 No No
7 empty 2.25 61.5 22.4 No No
8 empty 2.52 53.3 19.4 No No
9 empty 1.79 75.7 12.7 No No
10 empty 1.89 63.1 20 No No
4C3I_M DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 61.2 16.8 No No
2 empty 2.07 59.2 23.9 No No
3 empty 2.45 72.6 19.2 No No
4 empty 2.57 56.3 19.8 No No
5 empty 1.73 60.9 14.9 No No
6 empty 1.86 51.1 12.5 No No
7 empty 1.65 54.9 8.6 No No
8 empty 2.29 80.5 9.1 No No
9 empty 2.79 78.2 6.5 No No
10 empty 2.18 68.8 8.1 No No
6H67_M DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.61 77.1 21.9 Yes No
2 empty 2.01 59.3 27.1 No No
3 empty 2.28 57.2 26 No No
4 empty 2.47 70.7 9.3 No No
5 empty 2.19 64.3 19.3 No No
6 empty 2.64 70.5 10.9 No No
7 empty 2.24 62.7 10.6 No No
8 empty 2.35 56.1 11.9 No No
9 empty 2.72 74.3 8.7 No No
10 empty 2.99 46.6 8.9 No No
5G5L_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 74.5 19.7 Yes Yes
2 empty 2.05 56.3 26.4 No No
3 empty 2.06 62.2 20.1 No No
4 empty 2.13 59.4 15.1 No No
5 empty 2.59 79.9 9.2 No No
6 empty 2.15 73.5 9.8 No No
7 empty 1.85 70.6 8.7 No No
8 empty 2.29 56.2 10.4 No No
9 empty 2.23 59.6 7.5 No No
10 empty 2.81 48.4 7.6 No No
5M5X_M DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 61.8 22.8 No No
2 empty 2.55 73.2 10.2 No No
3 empty 2.35 58.6 14.9 No No
4 empty 2.47 63.8 20.2 No No
5 empty 2.18 63.7 9.9 No No
6 empty 2.15 60.6 13.7 No No
7 empty 2.62 67 16.6 No No
8 empty 2.2 56.8 16.4 No No
9 empty 2.57 82.6 0 No No
10 empty 1.22 62.2 13.1 No No
3NFI_A DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.6 65 36.1 Yes No
2 empty 2 65.4 29.8 No No
3 empty 2.3 62.1 21.9 No No
4 empty 2.43 65.8 18.1 No No
5 empty 2.35 62.8 16.1 No No
6 empty 2.07 64.1 11.7 No No
7 empty 1.95 69 11.7 No No
8 empty 2.26 61 19.6 No No
9 empty 1.8 58.3 10.6 No No
10 empty 2.28 58.8 12.1 No No
6H68_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 70.7 38.1 Yes Yes
2 empty 2.09 69.3 28.9 No No
3 empty 2.13 58.6 26.4 No No
4 empty 2.5 73.4 19.1 No No
5 empty 1.69 62.6 21.1 No No
6 empty 2.37 67.2 25.1 No No
7 empty 1.92 70.9 22 No No
8 empty 2.22 66.8 17.3 No No
9 empty 2.33 64 18.8 No No
10 empty 2.24 44.3 15.4 No No
3NFI_C DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.04 70.1 23.2 No No
2 empty 2.71 63.7 20.4 No No
3 empty 2.28 65.5 19.9 No No
4 empty 2.12 62.9 16.9 No No
5 empty 2.26 64.3 24.7 No No
6 empty 2.2 68.3 14.5 No No
7 empty 2.52 68.8 12.2 No No
8 empty 1.83 61.4 18.9 No No
9 empty 2.23 66.3 20.1 No No
10 empty 1.85 61.2 10.7 No No
5OA1_M DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 60.6 16.6 No No
2 empty 2.56 59.9 20.2 No No
3 empty 2.41 71 19.2 No No
4 empty 2.11 59.1 22.5 No No
5 empty 1.83 62.2 16.6 No No
6 empty 1.94 46.5 13.1 No No
7 empty 1.49 59.4 9.5 No No
8 empty 2.28 80.8 8.5 No No
9 empty 2.72 72.5 10.4 No No
10 empty 2.38 64.2 8.4 No No
5W5Y_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 70.2 24.1 Yes Yes
2 empty 2.2 60.8 23.3 No No
3 empty 1.39 61.5 15.9 No No
4 empty 1.86 60.6 14.1 No No
5 empty 2.65 67.1 11.4 No No
6 empty 2.19 56.3 8.4 No No
7 empty 1.93 51.7 9.6 No No
8 empty 2.4 65.8 9 No No
9 empty 2.81 45.2 9.8 No No
10 empty 2.87 44.1 10.3 No No
3NFI_B DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 66.6 36.1 Yes No
2 empty 2.36 62.1 37.5 No No
3 empty 2.12 64.6 34.4 No No
4 empty 2.49 70.5 18.6 No No
5 empty 1.97 59 21.1 No No
6 empty 2.63 52.8 18.6 No No
7 empty 1.88 73.6 8.5 No No
8 empty 2.36 65.6 15.7 No No
9 empty 2.44 65 12.1 No No
10 empty 2.08 63.5 14.7 No No
5M5Y_M DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.46 73.6 19.3 Yes No
2 empty 2.27 59.6 16.8 No No
3 empty 2.35 57.2 15.6 No No
4 empty 1.78 61.3 15.4 No No
5 empty 2.29 73.3 11.8 No No
6 empty 2.13 56.5 12.4 No No
7 empty 2.55 54.6 12.2 No No
8 empty 2.2 65.6 9.1 No No
9 empty 1.9 63.3 9.2 No No
10 empty 1.85 65.8 8.2 No No
5W65_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 70.9 20.5 Yes Yes
2 empty 2.16 61.6 25.9 No No
3 empty 1.35 65.4 16.4 No No
4 empty 1.85 61.1 15.1 No No
5 empty 1.91 67.3 10.8 No No
6 empty 2.24 52.2 10 No No
7 empty 2.55 67 12.5 No No
8 empty 2.06 50.9 10.1 No No
9 empty 2.05 68.7 9.1 No No
10 empty 2.28 66.5 9.7 No No
5N5Z_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 75.3 19.3 Yes Yes
2 empty 2.1 56.1 28.9 No No
3 empty 2.05 65.8 20 No No
4 empty 2 61.4 16.5 No No
5 empty 2.58 78.7 9.1 No No
6 empty 2.29 47.7 12.1 No No
7 empty 2.19 70.9 10.2 No No
8 empty 1.82 75.4 9.3 No No
9 empty 2.19 54.9 8.6 No No
10 empty 2.3 62 7.5 No No
4C2M_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.36 74.7 19.5 Yes Yes
2 empty 2.04 55.8 26.5 No No
3 empty 2.1 60.9 20.5 No No
4 empty 2.09 55.5 16.7 No No
5 empty 2.6 78.1 8.7 No No
6 empty 1.91 70 8.7 No No
7 empty 2.23 73.7 10.9 No No
8 empty 2.29 55.2 11.2 No No
9 empty 2.66 62.3 8.4 No No
10 empty 2.28 61.2 9.6 No No
4C2M_2 DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 56.3 26.3 Yes No
2 empty 2.74 75.3 12.6 No No
3 empty 2.02 54.7 16.6 No No
4 empty 1.89 61.8 15.2 No No
5 empty 1.86 70.2 12.3 No No
6 empty 2.24 74.1 10 No No
7 empty 2.26 55.7 10.6 No No
8 empty 2.28 62.4 9.1 No No
9 empty 2.31 59.3 10.2 No No
10 empty 2.82 47.1 7.9 No No
3NFI_D DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.45 63.8 43.9 Yes No
2 bound 2.25 72.6 20.5 No No
3 empty 2.65 59.3 24.3 No No
4 empty 2.29 61.4 29 No No
5 empty 2.38 68.8 23 No No
6 empty 2.38 64.3 18.2 No No
7 empty 2.48 67.4 18.6 No No
8 bound 1.72 70.7 14.9 No No
9 bound 1.33 98 0 Yes No
10 empty 1.92 69.4 11.4 No No
5N60_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 73.6 18.2 Yes Yes
2 empty 1.98 54 26.7 No No
3 empty 2.06 64.7 20 No No
4 empty 2.38 80.3 9.7 No No
5 empty 2.02 58.5 16.6 No No
6 empty 2.16 72 9.8 No No
7 empty 2.36 48.8 12.7 No No
8 empty 1.74 73.3 8.6 No No
9 empty 2.28 57.6 9.9 No No
10 empty 2.29 59.5 6.3 No No
3NFH_B DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.44 63.9 40.8 Yes No
2 empty 1.88 67.5 16.7 No No
3 empty 2.71 61.4 31.4 No No
4 empty 2.04 70.7 13.4 No No
5 empty 2.1 64 17.9 No No
6 empty 2.3 66.4 11.3 No No
7 empty 2.05 63.2 14.7 No No
8 empty 2.22 58.2 10 No No
9 empty 2.43 69.7 7.5 No No
10 empty 1.97 66.7 8.8 No No
5W64_M DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.4 69.5 22.5 No No
2 empty 2.4 62.4 23.2 No No
3 empty 1.38 68.2 17 No No
4 empty 2.49 71.4 11.4 No No
5 empty 2.07 51.1 10.3 No No
6 empty 2.19 55.5 9.9 No No
7 empty 2.35 66 9.2 No No
8 empty 1.97 67.3 7.8 No No
9 empty 2.42 70.4 9.2 No No
10 empty 2.89 44.4 10.2 No No
5M3M_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.33 74.7 18.5 Yes Yes
2 empty 2.01 56.4 28.6 No No
3 empty 2.1 62.7 18.6 No No
4 empty 2.41 81.2 9.3 No No
5 empty 2.07 57.1 13.9 No No
6 empty 1.91 71.6 8.4 No No
7 empty 2.14 75.2 9.1 No No
8 empty 2.3 54.9 9.4 No No
9 empty 2.62 68.1 7.4 No No
10 empty 2.35 64.3 6.6 No No
5M64_M DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.9 61.9 41.1 Yes No
2 empty 2.15 71.9 19.2 No No
3 empty 1.73 63.6 27.1 No No
4 empty 2.46 61.5 22.9 No No
5 empty 1.63 80.9 21.2 No No
6 empty 2.27 75.4 12.7 No No
7 empty 2.03 70.8 13.8 No No
8 empty 2.35 62.7 16.6 No No
9 empty 2.45 58.2 15.1 No No
10 empty 1.64 60.7 12.7 No No
5M5W_M DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.3 70.1 26 Yes No
2 empty 2.06 66.9 21.3 No No
3 empty 2.53 65.1 18.7 No No
4 empty 1.89 65.1 15.6 No No
5 empty 2.11 68.4 12.1 No No
6 empty 2.34 59.1 13.1 No No
7 empty 1.52 54.4 14.6 No No
8 empty 2.24 55.4 8.6 No No
9 empty 1.3 57.3 10.2 No No
10 empty 2.87 46 8.9 No No
5LMX_M DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.24 58.6 16 No No
2 empty 2.57 58.4 20.2 No No
3 empty 2.46 70.1 19.2 No No
4 empty 2.04 55.5 24.2 No No
5 empty 1.85 60.1 14.9 No No
6 empty 2.26 46.8 15.8 No No
7 empty 2.27 79.2 9.4 No No
8 empty 1.47 59.8 7.5 No No
9 empty 2.7 71.2 7.9 No No
10 empty 2.98 58 7.9 No No
6HKO_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.5 80.6 18.8 Yes Yes
2 empty 2.04 57.6 25.9 No No
3 empty 2.03 40 17.1 No No
4 empty 2.29 61.4 12.1 No No
5 empty 2.17 75.9 8.8 No No
6 empty 2.37 67.8 7.6 No No
7 empty 2.66 63.6 10.3 No No
8 empty 2.87 59.7 11.5 No No
9 empty 1.93 53.1 9.8 No No
10 empty 2.13 54.5 9.5 No No
5N61_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.41 77 18.1 Yes Yes
2 empty 1.92 55.7 25.7 No No
3 empty 2.24 60.1 16.5 No No
4 empty 2.06 64.6 12.6 No No
5 empty 2.4 57.7 10.4 No No
6 empty 2.28 55.9 9.4 No No
7 empty 2.78 41.7 8.2 No No
8 empty 2.52 71.1 7.6 No No
9 empty 2.6 44.9 9 No No
10 empty 2.62 58.1 8.8 No No
3NFH_A DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.29 66.8 27.6 Yes No
2 empty 1.96 64.5 36.4 No No
3 empty 2.65 60 27.6 No No
4 empty 2.18 71.3 11.7 No No
5 empty 2.31 70.8 12.6 No No
6 empty 2.49 69.3 12.6 No No
7 empty 2.28 66 12.6 No No
8 empty 2.03 74.7 9.1 No No
9 empty 1.84 60.5 9.9 No No
10 empty 2.02 58.9 11 No No
4C3J_M DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.21 60 17 No No
2 empty 2.37 68.6 17.8 No No
3 empty 2.48 59.2 19.8 No No
4 empty 2.11 58.4 24.7 No No
5 empty 1.9 61.8 14.4 No No
6 empty 1.89 48.1 11.8 No No
7 empty 2.32 81.4 9.1 No No
8 empty 1.46 56 9.2 No No
9 empty 2.74 71.5 9.3 No No
10 empty 2.87 51.4 8.2 No No
4C3H_M DNA-directed RNA polymerase I subunit RPA49 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.19 60.2 16.3 No No
2 empty 2.37 68.6 16.9 No No
3 empty 2.47 56 20.3 No No
4 empty 2.13 59.8 24.5 No No
5 empty 1.93 58.5 15.2 No No
6 empty 2.28 46.8 16.6 No No
7 empty 1.42 57.4 9.3 No No
8 empty 2.28 77.7 9.2 No No
9 empty 2.77 78.9 6.7 No No
10 empty 2.15 72.3 5.5 No No
5N5Y_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 74.8 19.4 Yes Yes
2 empty 2.05 55.8 29.2 No No
3 empty 2.06 61.6 20 No No
4 empty 1.96 61.9 14.5 No No
5 empty 2.6 82.5 9.3 No No
6 empty 1.82 72.6 9.8 No No
7 empty 2.34 48 12.6 No No
8 empty 2.24 79.9 8.6 No No
9 empty 2.29 57.3 9.2 No No
10 empty 2.24 63.2 6.8 No No
5M3F_M DNA-directed RNA polymerase I subunit RPA49 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 74.1 19 Yes Yes
2 empty 1.96 56.5 26.5 No No
3 empty 2.1 62.3 19.1 No No
4 empty 2.03 58.9 15 No No
5 empty 2.48 77.2 10 No No
6 empty 1.74 73.4 8.6 No No
7 empty 2.24 76.2 7.2 No No
8 empty 2.34 57.9 9.3 No No
9 empty 2.19 59.6 8.1 No No
10 empty 2.27 58.9 8.9 No No
3NFI_E DNA-directed RNA polymerase I subunit RPA49 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.31 65.1 43.9 Yes No
2 empty 2.41 68.2 34.7 No No
3 empty 1.84 62.2 18.7 No No
4 empty 2.26 73.1 14.1 No No
5 empty 2.03 74.2 9.6 No No
6 empty 1.87 63.2 14.5 No No
7 empty 2.22 61.7 11.7 No No
8 empty 2.1 67.2 12.9 No No
9 empty 1.97 63.2 15.9 No No
10 empty 2.12 60.6 11.6 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
3NFH_A (3560663) DNA-directed RNA polymerase I subunit RPA49 PFAM, PFAM, PFAM RNA_pol_I_A49 2.17Å Yes No
3NFI_A (3560664) DNA-directed RNA polymerase I subunit RPA49 PFAM, PFAM, PFAM RNA_pol_I_A49 1.9Å Yes No
Ligand-based Druggability Score:
Ligand-based Druggability Score Percentile: %
Ligand-based Druggability Help: Help




		
This protein has no network-based druggability score