Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MDM2 (Q00987) - Pathways - Molecular Target Synopsis

Data acquired from 22 pathway associations found
Pathway Name Source
AKT phosphorylates targets in the cytosolReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Constitutive Signaling by AKT1 E17K in CancerReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Oncogene Induced SenescenceReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Oxidative Stress Induced SenescenceReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Regulation of RUNX3 expression and activityReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Regulation of TP53 Activity through MethylationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Regulation of TP53 Activity through PhosphorylationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Regulation of TP53 DegradationReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Stabilization of p53Reactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SUMOylation of transcription factorsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
SUMOylation of ubiquitinylation proteinsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Trafficking of AMPA receptorsReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
Ub-specific processing proteasesReactome v61 (only 'Homo_sapiens.owl') 23-Jun-2017
AndrogenReceptorNetPath 12/2011
FSHNetPath 12/2011
Insulin/IGF pathway-protein kinase B signaling cascadePANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Integrated Breast Cancer Pathwaywikipathways
Integrated Cancer pathwaywikipathways
p53 pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
P53 pathway feedback loops 1PANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)
Tryptophan degradation ( Tryptophan degradation )INOH 4.0 (signal transduction and metabolic data), 22-MAR-2011
Ubiquitin proteasome pathwayPANTHER Pathways 3.4.1 on 04-Jul-2016 (auto-converted to human-only model)