Molecular Target Synopsis
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MDM2 (Q00987) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/07/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/07/2019)


Chains assessed210
Chains with at least one site assessed as druggable using the strict criteria10
Chains with at least one site assessed as druggable using the relaxed criteria128


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4HBM_E E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 76.8 17.1 Yes No
2 empty 2.4 52.4 18.7 No No
3 empty 1.82 51.6 10.7 No No
4 empty 2.57 51.9 9.4 No No
5 empty 2.21 64.8 7.6 No No
6 empty 1.76 66.7 6.5 No No
7 empty 2.2 69.9 7.1 No No
8 empty 1.26 57 8.9 No No
9 empty 1.08 61.7 7.4 No No
10 empty 3.19 59.8 7 No No
5MNJ_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 55.8 23.6 No No
2 empty 2.28 71.3 7.6 No No
3 empty 2.46 68.8 7.7 No No
4 empty 2.36 57.1 12.2 No No
5 empty 2.3 51 8.1 No No
6 empty 2.03 67.6 7.9 No No
7 empty 1.72 53.7 8.9 No No
8 empty 2.18 67.4 8.6 No No
9 empty 2.09 51.2 8.1 No No
10 empty 1.55 66 6 No No
4HBM_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 77.4 18.8 Yes No
2 empty 2.55 60.1 13.3 No No
3 empty 2.06 54.9 8.9 No No
4 empty 2.2 56 12.7 No No
5 empty 1.61 68.2 9.8 No No
6 empty 2.08 64.6 8.8 No No
7 empty 2.12 71.7 9.2 No No
8 empty 1.88 62.1 7.5 No No
9 empty 2.5 67.6 5.8 No No
10 empty 1.93 61.5 10 No No
4OBA_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 71.8 16.6 Yes No
2 empty 2.33 71.2 9.5 No No
3 empty 2.49 58.3 12.3 No No
4 empty 2.47 60.7 11.7 No No
5 empty 1.81 60.8 10.8 No No
6 empty 2.79 56.1 11.2 No No
7 empty 1.98 56.4 10.4 No No
8 empty 1.76 63.3 7.7 No No
9 empty 1.94 66.2 7.2 No No
10 empty 2.33 56.7 8.9 No No
5VK0_U E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 67.5 15.5 No No
2 empty 2.37 61.8 9.6 No No
3 empty 2.59 61.4 10.3 No No
4 empty 2.23 61.6 14.9 No No
5 empty 2.26 57.7 10.3 No No
6 empty 2.87 61.8 6.4 No No
7 empty 1.7 65.1 8.3 No No
8 empty 2.54 60.6 10.7 No No
9 empty 2.55 63 9.5 No No
10 empty 3 62.6 6.1 No No
5J7F_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 75.6 15.8 Yes No
2 empty 2.18 59.7 17 No No
3 empty 1.82 61.9 20.2 No No
4 empty 1.94 61.7 8.2 No No
5 empty 2.47 57.2 8.6 No No
6 empty 2.17 49.4 8.1 No No
7 empty 1.94 71.5 6.4 No No
8 empty 2.46 65.3 6 No No
9 empty 1.86 68.1 6.4 No No
10 empty 3.29 64.3 5 No No
2GV2_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.55 69.2 20.4 No No
2 empty 1.9 63.5 13.1 No No
3 empty 2.8 58.3 12 No No
4 empty 2.1 51.5 9.8 No No
5 empty 2.79 60.9 12.1 No No
6 empty 2.79 54.3 10.1 No No
7 empty 1.84 62.6 8 No No
8 empty 2.74 54.3 10.6 No No
9 empty 2.98 54.5 7.3 No No
10 empty 3.07 78.3 0 No No
5HMH_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 69.8 14.6 No No
2 empty 2.18 63.4 18.5 No No
3 empty 2.69 57.2 13.8 No No
4 empty 1.93 55.1 10.6 No No
5 empty 2.25 66.9 12.8 No No
6 empty 2.14 59.6 13.6 No No
7 empty 2.87 53.4 11.4 No No
8 empty 2.2 59.4 10.2 No No
9 empty 2.93 57.1 7.7 No No
10 empty 2 61.3 10.1 No No
2RUH_A E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 68.4 27.1 Yes Yes
2 empty 2.16 59.8 22.8 No No
3 empty 2.31 68.5 17.7 No No
4 empty 2.78 53.9 21.6 No No
5 empty 2.3 58.8 14.6 No No
6 empty 2.39 65.6 10.9 No No
7 empty 2.58 63.9 14.4 No No
8 empty 2.22 62.3 14 No No
9 empty 3.14 65.7 7.3 No No
10 empty 2.03 76 6.1 No No
3LNZ_M E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 74.9 13.7 Yes No
2 empty 2.14 54.5 14.3 No No
3 empty 1.86 70.1 7.1 No No
4 empty 2.83 62.7 10.3 No No
5 empty 2.54 56.2 7.8 No No
6 empty 2.11 72.7 9.1 No No
7 empty 2.87 63.8 6.2 No No
8 empty 2.33 65.3 6.6 No No
9 empty 2.28 63.3 7 No No
10 empty 2.97 79.6 5.6 No No
4MDQ_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 70.9 18.9 No No
2 empty 2.14 59.5 8.5 No No
3 empty 2.45 72.1 5.4 No No
4 empty 2.12 74.8 7.3 No No
5 empty 1.3 61.1 6.6 No No
6 empty 3.11 66.2 5.5 No No
7 empty 1.79 64.5 7.6 No No
8 empty 2.32 59.3 4.9 No No
9 empty 3.12 69.1 6 No No
10 empty 1.85 81 6.8 No No
2HDP_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 71.9 19.4 Yes No
2 empty 1.52 73.4 21.1 Yes No
3 empty 2.4 61 15.1 No No
4 empty 2.92 64.3 8.7 No No
5 empty 1.51 48.8 8.2 No No
6 empty 2.4 68.2 6.7 No No
7 empty 2.36 63.8 4.6 No No
8 empty 2.75 55 6.4 No No
9 empty 2.32 63.9 5.8 No No
5VK0_G E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 69.8 19.3 No No
2 empty 2.24 69.1 8.8 No No
3 empty 2.11 55.2 9.6 No No
4 empty 2.58 70.1 6.5 No No
5 empty 2.19 72.4 7.6 No No
6 empty 2.93 60.2 11.9 No No
7 empty 2.78 53.7 9.6 No No
8 empty 2.77 39.8 7.2 No No
9 empty 1.93 67.7 6.7 No No
10 empty 2.81 64.9 8 No No
2VJE_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 61.2 22 No No
2 empty 2 52.6 14.6 No No
3 empty 2.2 57.3 11.6 No No
4 empty 2.36 60.8 13.2 No No
5 empty 2.36 68.3 8.4 No No
6 empty 1.97 62.1 9.2 No No
7 empty 2.69 58.7 8 No No
8 empty 2.23 67 5.9 No No
9 empty 2.21 60 6.8 No No
10 empty 2.85 42 5.8 No No
3LBL_E E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.39 73.6 16.3 Yes No
2 empty 2.58 58.1 9.6 No No
3 empty 1.86 63 10.3 No No
4 empty 1.77 61.7 11 No No
5 empty 2.45 70 6.1 No No
6 empty 1.65 63.4 9 No No
7 empty 2.37 68.9 6 No No
8 empty 2.83 55.9 8.8 No No
9 empty 2.78 69.4 7.5 No No
10 empty 2.89 66.4 5.9 No No
5J7F_D E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 71.3 20.1 Yes No
2 empty 1.66 60.2 13.1 No No
3 empty 2.16 62.9 12 No No
4 empty 3 54.6 9.4 No No
5 empty 2.43 54.8 8.9 No No
6 empty 1.71 73.5 6 No No
7 empty 1.78 73.6 6.4 No No
8 empty 3.26 65.2 6.9 No No
9 empty 2.08 74.2 0 No No
10 empty 2.54 65.5 5.4 No No
4UMN_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.79 70.2 19.2 No No
2 empty 2.34 55.6 16.3 No No
3 empty 2.35 61.3 12.2 No No
4 empty 2.44 61.9 7.8 No No
5 empty 2.12 56 8.9 No No
6 empty 2.64 73 6.3 No No
7 empty 2.43 64.2 5.4 No No
8 empty 2.08 66.3 5.5 No No
9 empty 3.03 59.4 7 No No
10 empty 2.11 54.8 6.3 No No
3IUX_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 73.1 11.8 Yes No
2 empty 1.94 64.2 12.9 No No
3 empty 2.35 57.8 10.6 No No
4 empty 2.12 53.2 9.6 No No
5 empty 2.01 72.4 9.4 No No
6 empty 2.35 75 6.7 No No
7 empty 2.95 46.8 8.7 No No
8 empty 2.64 63.4 8.3 No No
9 empty 2.35 61 7.3 No No
10 empty 1.92 66.3 5.9 No No
3LNZ_I E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 70.2 15.5 No No
2 empty 2.32 65.8 11.4 No No
3 empty 2.5 60.6 10.1 No No
4 empty 2.12 61.4 9.7 No No
5 empty 2.58 65.8 14.8 No No
6 empty 2.32 73.4 5.9 No No
7 empty 2.93 63.1 7.3 No No
8 empty 2.29 64.9 7.7 No No
9 empty 2.74 57.8 7 No No
10 empty 1.79 60.5 7.1 No No
2VJE_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 61.6 14.4 No No
2 empty 1.58 55.4 14 No No
3 empty 2.32 60.3 10.5 No No
4 empty 2 53.6 13.7 No No
5 empty 2.59 64.4 10.3 No No
6 empty 1.88 61.3 11.3 No No
7 empty 2.07 66.4 6.8 No No
8 empty 2.74 65.5 7 No No
9 empty 2.91 46.2 6 No No
10 empty 2.14 58.1 5.5 No No
4ZGK_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.53 60.8 20.7 No No
2 bound 1.89 73.2 13.8 No No
3 empty 2.01 54.1 14.5 No No
4 empty 2.06 64.3 12.4 No No
5 empty 2.02 67.5 8.1 No No
6 empty 1.9 68.6 6.5 No No
7 empty 2.39 50.6 8.2 No No
8 empty 2.33 54.7 8.9 No No
9 empty 1.95 66.7 6.4 No No
10 empty 1.84 58.4 5.9 No No
3LBL_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 71 18.5 No No
2 empty 2.41 55.7 11.1 No No
3 empty 2.28 66.7 7.6 No No
4 empty 2.86 53.7 13.1 No No
5 empty 2.35 52.2 10.6 No No
6 empty 2.83 56.4 9.5 No No
7 empty 2.33 61.3 7.2 No No
8 empty 1.75 66.7 9 No No
9 empty 1.83 63.6 9.5 No No
10 empty 1.95 62.7 8.1 No No
3VZV_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 67.6 23.6 No No
2 empty 2.33 62.9 17.5 No No
3 empty 2.44 55.9 11.2 No No
4 empty 2.53 52.6 10.1 No No
5 empty 2.6 52 9.6 No No
6 empty 2.35 67.6 5.8 No No
7 empty 2.13 66.7 6.3 No No
8 empty 1.7 51.9 8.3 No No
9 empty 2.22 62.4 8.4 No No
10 empty 1.84 65.5 6.6 No No
4OBA_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 68.1 17.3 No No
2 empty 2.34 64.4 14.8 No No
3 empty 2.45 62.6 10.6 No No
4 empty 2.05 68.1 7.4 No No
5 empty 2.03 57.8 8.8 No No
6 empty 2.81 45 8.1 No No
7 empty 1.84 56.5 9.3 No No
8 empty 1.87 62.8 6.3 No No
9 empty 1.87 60 10.5 No No
10 empty 3.03 52.6 8.8 No No
3G03_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 67 21 No No
2 empty 2.17 53.7 11 No No
3 empty 2.62 60.3 8.1 No No
4 empty 1.73 61.7 8 No No
5 empty 2.77 52.1 7.3 No No
6 empty 2.93 64.4 6.7 No No
7 empty 2.11 70 5.1 No No
8 empty 2.46 65.7 6.4 No No
9 empty 2.53 72.4 6 No No
10 empty 2.72 62.6 6.8 No No
2C6A_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.99 55.5 14.3 No No
2 empty 2.45 58.6 13 No No
3 empty 2.58 52.1 13.8 No No
4 empty 2.73 71 15.3 No No
5 empty 1.72 71.2 9 No No
6 empty 1.95 52.1 7.4 No No
7 empty 2.43 65.4 6.8 No No
8 empty 3.33 61 6.9 No No
9 empty 2.49 65.9 5.4 No No
10 empty 2.98 63.2 6.9 No No
5VK0_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 72.4 14.2 Yes No
2 empty 1.94 64.2 13.3 No No
3 empty 2.2 56.1 11.4 No No
4 empty 2.96 60.1 12.5 No No
5 empty 2.11 51.7 10.7 No No
6 empty 2.45 72.9 6.6 No No
7 empty 2.41 46.3 10 No No
8 empty 1.86 75.4 8.4 No No
9 empty 2.36 65.3 5.8 No No
10 empty 2.94 58 5.4 No No
3IUX_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.62 74.4 11.5 Yes No
2 empty 1.96 58.7 15.8 No No
3 empty 2.3 59.3 10.5 No No
4 empty 2.15 53.2 10 No No
5 empty 2.85 53.3 11.4 No No
6 empty 1.86 65.2 7.1 No No
7 empty 2.15 64.7 7.2 No No
8 empty 1.87 62.8 11 No No
9 empty 3.16 43.7 7.1 No No
10 empty 1.93 54.6 6.2 No No
5XXK_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 72.9 16.2 Yes No
2 empty 2.08 55.3 16.6 No No
3 empty 2.04 60 16 No No
4 empty 2.31 52.9 12.7 No No
5 empty 2.06 54.7 7.9 No No
6 empty 2.56 49.8 10.5 No No
7 empty 1.65 70.5 7.3 No No
8 empty 2.63 66.5 9.1 No No
9 empty 3.14 71.3 5.8 No No
10 empty 3.63 68.1 6.8 No No
5LN2_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 69.5 19 No No
2 empty 2.86 62.4 10.7 No No
3 empty 2.31 54.7 10.9 No No
4 empty 1.66 69.3 7.7 No No
5 empty 2.14 64.4 9.1 No No
6 empty 2.37 63.2 9.2 No No
7 empty 2.4 73.7 5.6 No No
8 empty 2.85 46.6 8.2 No No
9 empty 2.14 66.1 7.5 No No
10 empty 2.63 58.2 7.9 No No
4OCC_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.98 70.6 16.8 No No
2 empty 2.82 56.9 19.5 No No
3 empty 2.27 67.7 9.4 No No
4 empty 1.71 67.1 10.3 No No
5 empty 2.81 62.7 9.1 No No
6 empty 2.38 56.5 10.1 No No
7 empty 1.55 63.7 11.1 No No
8 empty 1.95 61 9.8 No No
9 empty 2.46 58.6 9.7 No No
10 empty 2.02 58.1 7.5 No No
3V3B_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.47 71.7 19.1 Yes No
2 empty 1.81 67.1 12.8 No No
3 empty 2.05 59.6 10.3 No No
4 empty 1.93 49.4 8.4 No No
5 empty 2.36 66.7 7.3 No No
6 empty 2.11 67 6.3 No No
7 empty 2.48 65 5.2 No No
8 empty 2.35 64.7 4.4 No No
9 empty 2.72 66.7 5.4 No No
10 empty 2 73.4 5.6 No No
1RV1_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 62.3 31.3 Yes No
2 empty 2.56 49.6 12.4 No No
3 empty 2.34 60.3 6.9 No No
4 empty 2.85 68.5 10.1 No No
5 empty 2.07 74.2 6.6 No No
6 empty 1.8 64.8 8.2 No No
7 empty 2.13 58.3 10.8 No No
8 empty 2.95 63.9 5.9 No No
9 empty 1.72 48.4 7.6 No No
10 empty 3.25 60 6.4 No No
4OCC_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.75 71.5 15.3 Yes No
2 empty 2.4 63.6 16.2 No No
3 empty 2.51 55.6 9.8 No No
4 empty 2.42 65.4 15.1 No No
5 empty 2.64 56.1 10.6 No No
6 empty 2.75 68.2 9.5 No No
7 empty 2.04 65.3 9.2 No No
8 empty 1.87 55.1 9.5 No No
9 empty 1.83 62.4 7.9 No No
10 empty 2 57.5 7.5 No No
5VK0_M E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 72.4 15.5 Yes No
2 empty 2.41 67.8 12.6 No No
3 empty 2.17 53.1 14.2 No No
4 empty 2.34 60 11.2 No No
5 empty 2.38 61 13.9 No No
6 empty 1.93 68.3 6.4 No No
7 empty 3.11 62.6 8.5 No No
8 empty 2.92 77.5 0 No No
9 empty 1.16 66.7 6.2 No No
10 empty 3.09 58.6 6.6 No No
3JZS_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.75 68.4 18.6 No No
2 empty 2.33 61.3 11.8 No No
3 empty 2.36 55.1 10.1 No No
4 empty 2.3 56.9 8.2 No No
5 empty 2.16 58.7 8.4 No No
6 empty 2.61 62.5 7.1 No No
7 empty 1.55 57 8.4 No No
8 empty 2.33 75.9 5.9 No No
9 empty 1.99 70.4 6.4 No No
10 empty 3.03 70.1 5.1 No No
5HMK_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 69.5 24.9 Yes No
2 empty 2.49 55.6 16.5 No No
3 empty 2.58 59.9 14.8 No No
4 empty 2.72 60.4 10.2 No No
5 empty 1.48 66.4 7 No No
6 empty 2.84 64.2 8.5 No No
7 empty 1.86 69 6.8 No No
8 empty 1.85 73.5 6.6 No No
9 empty 3.03 65.7 6.6 No No
10 empty 2.52 67 7.5 No No
3TPX_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 66.3 20.9 No No
2 empty 2.18 59.9 23.7 No No
3 empty 2.09 52.3 16 No No
4 empty 2.34 61 10.3 No No
5 empty 2.56 59.4 10.5 No No
6 empty 2.51 62 8.4 No No
7 empty 1.9 55.8 9.9 No No
8 empty 2.44 69.5 6.4 No No
9 empty 1.8 65.6 6.8 No No
10 empty 2.92 68.6 5.7 No No
4OQ3_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 72 17.6 Yes No
2 empty 2.54 58.9 12.8 No No
3 empty 2.5 74.6 7.3 No No
4 empty 2.28 60.1 8.7 No No
5 empty 1.84 49.4 5.6 No No
6 empty 2.84 75.8 0 No No
7 empty 2.29 70.3 4.8 No No
8 empty 3.12 59.8 6.2 No No
9 empty 2.69 63.3 5.7 No No
10 empty 2.8 82.2 0 No No
5LAY_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 73.7 16.8 Yes No
2 empty 2.34 66 13 No No
3 empty 2.38 64.5 11 No No
4 empty 2.34 60.1 12.3 No No
5 empty 2.97 60.5 9.9 No No
6 empty 2.27 50.3 10.5 No No
7 empty 2.58 63.9 9.5 No No
8 empty 2.2 53.5 7.8 No No
9 empty 2.75 59 7.7 No No
10 empty 2.6 58 6.9 No No
4JVR_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 74.6 19.7 Yes No
2 empty 2.48 58.6 12.3 No No
3 empty 2.53 60.5 7.8 No No
4 empty 2.67 59.2 10.3 No No
5 empty 2.59 64.9 9.5 No No
6 empty 1.87 64.6 8 No No
7 empty 1.71 62.9 8.9 No No
8 empty 1.89 51.5 9.8 No No
9 empty 2.53 61.2 7.1 No No
10 empty 1.94 67.6 5.5 No No
5ZXF_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 70.6 21 No No
2 empty 2.79 61.8 16.8 No No
3 empty 2.38 56.2 15.3 No No
4 empty 2.27 50.6 12.1 No No
5 empty 2.55 60.7 10.2 No No
6 empty 1.84 65.9 7.7 No No
7 empty 2.91 73.6 5.8 No No
8 empty 2.42 67.2 8.1 No No
9 empty 1.99 62.4 6.3 No No
10 empty 2.48 54.5 8.2 No No
4UE1_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.42 54.5 28.2 Yes No
2 empty 1.73 66 25.1 No No
3 empty 2.33 55.7 11.7 No No
4 empty 2.51 50.7 12.1 No No
5 empty 1.92 67.9 9.6 No No
6 empty 2.15 80.4 6.9 No No
7 empty 1.92 74.8 6.8 No No
8 empty 2.28 65.6 8.3 No No
9 empty 2.72 55.9 8.1 No No
10 empty 2.66 64.6 4.9 No No
4QOC_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 67.7 19.3 No No
2 empty 2.26 64.2 11.9 No No
3 empty 2.59 70.5 7.7 No No
4 empty 2.21 63.9 10.4 No No
5 empty 2.87 64.1 10.3 No No
6 empty 2.59 66.3 11.8 No No
7 empty 2.14 64.3 9.2 No No
8 empty 2.72 51.2 8.4 No No
9 empty 2.89 73.8 5 No No
10 empty 1.86 80.4 5.4 No No
4OGV_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.47 69.4 15.8 No No
2 empty 2.51 62.6 13.4 No No
3 empty 1.75 65 9.8 No No
4 empty 1.98 73.6 8.3 No No
5 empty 2 67.4 7.1 No No
6 empty 2.32 57.8 8.6 No No
7 empty 1.83 56.1 10.6 No No
8 empty 1.45 61.5 7.4 No No
9 empty 2.3 64.8 6.2 No No
10 empty 2.71 57.4 8.5 No No
2VJF_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 62.9 18.5 No No
2 empty 1.85 57.9 19.7 No No
3 empty 2.2 60.5 11.1 No No
4 empty 1.84 53.3 14.9 No No
5 empty 2.42 68.2 8.9 No No
6 empty 2.39 56 8.3 No No
7 empty 2.41 62.9 10.8 No No
8 empty 2.02 69.9 6.6 No No
9 empty 2.28 66.1 6.9 No No
10 empty 1.95 69.2 5.4 No No
5J7G_D E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 71.2 20.5 No No
2 empty 2.27 64.3 12.6 No No
3 empty 1.57 52.5 10.7 No No
4 empty 2.16 55.6 6.8 No No
5 empty 2.29 64.5 8.3 No No
6 empty 1.51 61.6 6.5 No No
7 empty .99 59.8 6 No No
8 empty 1.88 68.4 4.7 No No
9 empty 3.15 64.1 5.1 No No
10 empty 2.57 72.7 0 No No
4ZYC_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.56 68.1 19.2 No No
2 empty 2.24 61.6 11.1 No No
3 empty 2.43 61.8 11.2 No No
4 empty 2.81 62 12.8 No No
5 empty 2 63.6 9.1 No No
6 empty 2.7 57.8 10.4 No No
7 empty 1.59 54.1 11 No No
8 empty 2.22 64.5 6.7 No No
9 empty 2.18 54.3 6.7 No No
10 empty 2.01 72.2 6.4 No No
6Q9O_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.43 76.4 13 Yes No
2 empty 2 63.1 10 No No
3 empty 2.48 61.6 15.3 No No
4 empty 2.8 64.5 8.9 No No
5 empty 1.96 64.8 8.5 No No
6 empty 1.94 54.8 10.1 No No
7 empty 2.84 59.5 10 No No
8 empty 2.19 69.2 8.2 No No
9 bound 2.33 72.2 5.7 No No
10 empty 1.8 58.8 5.2 No No
5LAY_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.79 68.4 22.2 No No
2 empty 2.24 57.7 13.5 No No
3 empty 2.67 55.7 9.3 No No
4 empty 2.32 59.3 13.7 No No
5 empty 1.78 62.7 10.6 No No
6 empty 2.07 65.3 9.9 No No
7 empty 2.11 70.4 6.4 No No
8 empty 2.08 60.2 7.5 No No
9 empty 2.73 54.6 6.9 No No
10 empty 2.73 62.9 6.5 No No
4HG7_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 74 18.6 Yes No
2 empty 2.06 62.8 12.3 No No
3 empty 1.81 59.6 10.4 No No
4 empty 2.47 58.6 8.8 No No
5 empty 2.64 52.1 8 No No
6 empty 1.98 62.9 8.2 No No
7 empty 1.91 65.6 9.1 No No
8 empty 2.05 70.5 7.1 No No
9 empty 2.14 63.1 6.8 No No
10 empty 2.98 65.8 6.2 No No
5C5A_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.84 66.2 25.7 Yes No
2 empty 2.34 59.6 14.4 No No
3 empty 2.22 65 11.5 No No
4 empty 2.11 58.7 12.3 No No
5 empty 2.1 74.2 9.5 No No
6 empty 1.81 57.3 9.2 No No
7 empty 2.24 53.8 7.7 No No
8 empty 3.09 56.2 8.6 No No
9 empty 2.02 52.7 6.9 No No
10 empty 2.31 74.7 0 No No
3VBG_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 69 17.8 No No
2 empty 2 63.7 15.3 No No
3 empty 2.44 57.4 11.5 No No
4 empty 2.25 67.4 14.2 No No
5 empty 2.86 56 9.9 No No
6 empty 2.03 65.4 6.6 No No
7 empty 1.61 58.1 7.5 No No
8 empty 2.15 74.6 5.7 No No
9 empty 2.4 63.5 6.2 No No
10 empty 2.2 69.9 5.4 No No
3LNZ_K E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 72.5 15.9 Yes No
2 empty 2.17 54.6 10.7 No No
3 empty 2.16 58.3 8.4 No No
4 empty 1.99 68.8 7.3 No No
5 empty 2.3 64.5 7 No No
6 empty 2.81 58.1 9.1 No No
7 empty 2.59 67.8 6.3 No No
8 empty 2.5 62.6 7.2 No No
9 empty 1.72 52 7.4 No No
10 empty 2.93 45.5 8.9 No No
3LNZ_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 77.4 11.1 Yes No
2 empty 2.17 67 14.9 No No
3 empty 2.66 60.5 9.9 No No
4 empty 2.69 58.7 12.5 No No
5 empty 2.79 69.1 9.2 No No
6 empty 2.65 55.6 8.7 No No
7 empty 2.23 70.2 6.6 No No
8 empty 2.16 68.8 6.6 No No
9 empty 2.41 64.2 6.6 No No
10 empty 1.96 64.4 7 No No
4ZFI_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.91 74 14.7 Yes No
2 empty 2.01 52.6 13.1 No No
3 empty 2.25 58.9 19.7 No No
4 empty 2.48 55.1 14.3 No No
5 empty 2.49 64 11.9 No No
6 empty 1.64 61.2 9.5 No No
7 empty 2.27 71.7 6.8 No No
8 empty 1.44 69.7 5.5 No No
9 empty 1.75 71.1 8.2 No No
10 empty 2.52 77 0 No No
4HFZ_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.94 62.8 30.6 Yes No
2 empty 2.17 65.6 11.3 No No
3 empty 1.94 55.4 12.2 No No
4 empty 2.73 54.7 10.5 No No
5 empty 2.61 63 11.6 No No
6 empty 2.23 73 7.7 No No
7 empty 2.21 59.8 9.2 No No
8 empty 1.88 65.6 9.9 No No
9 empty 2.89 66.9 5.6 No No
10 empty 1.73 62.3 6.8 No No
5XXK_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 73.7 18.1 Yes No
2 empty 2.35 55.6 16 No No
3 empty 2.37 51.9 12.3 No No
4 empty 2.28 56.7 12.9 No No
5 empty 2.81 76.2 6.1 No No
6 empty 2.86 46.5 8.4 No No
7 empty 2.26 66.7 6.3 No No
8 empty 2.28 73.5 6.2 No No
9 empty 1.17 49.4 5.6 No No
10 empty 3.18 60.5 6.3 No No
5LAZ_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 70.8 15.2 No No
2 empty 2.41 57.9 19.5 No No
3 empty 2.65 51.1 19 No No
4 empty 2.13 56.5 12.1 No No
5 empty 2.56 62 13.7 No No
6 empty 2.03 67.9 9.5 No No
7 empty 1.71 64.7 8.1 No No
8 empty 1.92 59.9 5.4 No No
9 empty 2.51 75 6.2 No No
10 empty 2.93 58.1 7.6 No No
5VK0_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 69 17.9 No No
2 empty 2.39 62.5 20.3 No No
3 empty 2.26 64.1 14.2 No No
4 empty 2.2 52.5 14 No No
5 empty 2.5 65.1 14.1 No No
6 empty 2.34 62.7 11.3 No No
7 empty 2.43 49.7 9.1 No No
8 empty 2.82 67.7 7.4 No No
9 empty 2.47 63.6 7.3 No No
10 empty 2.2 65.4 6.5 No No
2MPS_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 61.6 32.7 Yes No
2 empty 2.56 45.9 14.5 No No
3 empty 2.29 51.7 14.1 No No
4 empty 2.49 47.8 11.6 No No
5 empty 2.42 48.9 13.6 No No
6 empty 2.44 52.5 8.5 No No
7 empty 2.39 62.2 8.1 No No
8 empty 1.96 64.3 8.5 No No
9 empty 2.69 55 10.2 No No
10 empty 2.55 72.9 9 No No
5J7G_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 74.2 20.6 Yes No
2 empty 1.57 48.8 9.7 No No
3 empty 1.83 63.5 7.7 No No
4 empty 2.35 58.7 7.5 No No
5 empty 3.09 61 9.3 No No
6 empty 2.06 73 5.9 No No
7 empty .77 55.7 6.5 No No
8 empty 1.43 74.3 5.5 No No
9 empty 2.98 63.9 5.2 No No
10 empty 3.08 62.8 6 No No
1T4E_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 71.6 18.6 Yes No
2 empty 1.95 64.5 14.1 No No
3 empty 2.12 52.1 13.4 No No
4 empty 2.38 61.2 12.1 No No
5 empty 2.35 70.5 7.2 No No
6 empty 2.32 67.7 7.6 No No
7 empty 2.97 55.3 7 No No
8 empty 2.01 72.8 5.4 No No
9 empty 2.46 42.6 7.3 No No
10 empty 2.06 59.2 7.2 No No
5LAV_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 70.1 16.2 No No
2 empty 2.44 61.9 14.9 No No
3 empty 2.2 58 12.1 No No
4 empty 2.68 60.3 15.6 No No
5 empty 2.29 53.3 12.9 No No
6 empty 2.58 66.1 8.2 No No
7 empty 2.74 59.7 9.7 No No
8 empty 1.85 63.1 7.9 No No
9 empty 1.84 65.2 9.7 No No
10 empty 2.26 57.8 9.5 No No
4UD7_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 70.4 26.7 Yes No
2 empty 2.07 63.9 10.8 No No
3 empty 1.53 69.6 6.6 No No
4 empty 2.45 56.9 11.5 No No
5 empty 2.84 60.8 10.4 No No
6 empty 2.77 52.8 9.4 No No
7 empty 2.6 66.2 7.7 No No
8 empty 2.33 62.2 7.5 No No
9 empty 2.03 61.3 11.9 No No
10 empty 2.05 62.4 6.6 No No
1RV1_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.37 63.1 21.6 No No
2 bound 1.49 74.5 14.7 Yes No
3 empty 2.56 60.1 13.8 No No
4 empty 2.16 68 9 No No
5 empty 2.36 57.5 11.1 No No
6 empty 2.5 61.5 17 No No
7 empty 2.44 53.7 10.7 No No
8 empty 2.46 66.5 7.6 No No
9 empty 1.73 63.2 7.1 No No
10 empty 2.51 71.6 6 No No
4JVR_E E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.77 73.7 15 Yes No
2 empty 2.11 62.3 8.5 No No
3 empty 2.35 63 12.7 No No
4 empty 2.65 59.2 8 No No
5 empty 2.47 61.2 7.7 No No
6 empty 2.33 60.3 11 No No
7 empty 1.75 64 9.3 No No
8 empty 2.78 73.6 8 No No
9 empty 1.96 59.9 6.9 No No
10 empty 2.94 61.8 8.3 No No
4OCC_E E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 67.3 25.3 Yes No
2 empty 2.3 63.5 13.9 No No
3 empty 2.43 60.4 10.2 No No
4 empty 2.21 60.8 13.5 No No
5 empty 2.51 60.6 10.6 No No
6 empty 2.24 67 8.5 No No
7 empty 2.06 64 8.8 No No
8 empty 1.74 63.3 8.3 No No
9 empty 2.36 60.5 6.8 No No
10 empty 2.18 62.6 7.9 No No
2C6B_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 55.5 12.6 No No
2 empty 2.76 50.8 11.4 No No
3 empty 2.61 64 13.4 No No
4 empty 2.55 55.9 12.3 No No
5 empty 2.91 58.8 9.8 No No
6 empty 2.97 66.5 7.5 No No
7 empty 2.32 66.5 8.8 No No
8 empty 2.64 58.4 8.3 No No
9 empty 2.08 59.8 7.2 No No
10 empty 3.06 59.6 5 No No
5LAY_D E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 69.1 17.9 No No
2 empty 1.84 58.2 16.8 No No
3 empty 2.32 57.7 14 No No
4 empty 2.91 59.4 7.8 No No
5 empty 1.98 55.5 9 No No
6 empty 1.96 59.8 7.1 No No
7 empty 1.74 48.6 7.8 No No
8 bound 3.51 66.7 5.5 No No
9 empty 2.77 69.9 6 No No
10 empty 1.99 52 6.4 No No
3JZR_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.86 69.7 18.7 No No
2 empty 2.02 60.9 12.3 No No
3 empty 2.35 62.5 8.3 No No
4 empty 2.55 62.6 13.1 No No
5 empty 1.79 60.9 9.2 No No
6 empty 3.09 61.3 9.2 No No
7 empty 2.23 61.9 8.7 No No
8 empty 2.38 47.9 8.2 No No
9 empty 1.85 64.8 8.5 No No
10 empty 1.98 64.8 8.9 No No
5VK0_O E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.45 73.6 13.6 Yes No
2 empty 2.28 64.9 9.5 No No
3 empty 2.69 59.3 10.6 No No
4 empty 2.96 61.8 7.5 No No
5 empty 2.04 67.6 8.5 No No
6 empty 2.86 61.8 6.7 No No
7 empty 2.48 53.6 9.1 No No
8 empty 2.63 53.8 8.5 No No
9 empty 2.66 68.8 7 No No
10 empty 1.77 72.7 5.3 No No
3JZK_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 75.4 13.4 Yes No
2 empty 2.21 59.5 14.7 No No
3 empty 2.37 58.5 13.7 No No
4 empty 2.3 66.9 7.6 No No
5 empty 1.69 66.3 6.2 No No
6 empty 1.9 49.5 7.3 No No
7 empty 2.33 65.8 4.7 No No
8 empty 3.35 52.4 5.4 No No
9 empty 2.05 48.9 6 No No
10 empty 2.95 73.9 0 No No
2VJF_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 58.8 22.8 No No
2 empty 1.93 53.7 13.6 No No
3 empty 2.25 63.4 8.6 No No
4 empty 2.39 68 8 No No
5 empty 2.47 70.2 5.9 No No
6 empty 2.03 67.8 7.5 No No
7 empty 2.33 67.3 5.3 No No
8 empty 2.13 62.3 7.9 No No
9 empty 3.21 56.1 4.2 No No
4OAS_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 73.3 14.1 Yes No
2 empty 2.59 58 16.2 No No
3 empty 2.71 59.9 12.2 No No
4 empty 1.77 59.9 12.9 No No
5 empty 2.3 67.6 9.5 No No
6 empty 2.41 57.4 9.6 No No
7 empty 1.55 63.5 7 No No
8 empty 1.79 62.3 9.7 No No
9 empty 2.41 57.6 7.2 No No
10 empty 1.75 57.3 8.3 No No
1Z1M_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.01 58.5 28.7 Yes No
2 empty 2.31 65 20.2 No No
3 empty 2.36 72.7 11.7 No No
4 empty 2.67 51.3 14.3 No No
5 empty 2 69.4 8.8 No No
6 empty 2.54 61.1 11.8 No No
7 empty 1.84 64.7 7.9 No No
8 empty 3.09 48.8 7.8 No No
9 empty 1.82 62.4 8.6 No No
10 empty 3.1 61.9 8.1 No No
6Q9L_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.83 71.2 26.4 Yes No
2 empty 1.97 60.7 13.5 No No
3 empty 2.69 59.4 13.7 No No
4 empty 1.87 59.1 11.2 No No
5 empty 2.37 52.2 10.2 No No
6 empty 1.7 69.6 9 No No
7 empty 2.14 69.9 8.7 No No
8 empty 2.07 54.6 10.4 No No
9 empty 3.22 64 6.1 No No
10 empty 2.44 58 8.3 No No
6Q96_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.5 66.3 24.7 Yes No
2 bound 2.28 67.4 13.5 No No
3 empty 1.59 59 15.2 No No
4 empty 2.21 49.8 12.1 No No
5 empty 2.2 68.7 8.9 No No
6 empty 2.08 70.4 5.4 No No
7 empty 2.54 57.5 6.9 No No
8 empty 1.44 56.1 6.9 No No
9 empty 2.06 70.8 5 No No
10 bound 2.73 53.3 8.2 No No
6GGN_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.12 72.2 15.8 Yes No
2 empty 2.4 63.9 19.8 No No
3 empty 2.61 57.2 19.1 No No
4 empty 2.23 55.9 10.2 No No
5 empty 1.73 64.8 9.6 No No
6 empty 2.12 62.8 9.1 No No
7 empty 1.74 66.2 6.6 No No
8 empty 2.47 56.1 10 No No
9 empty 2.14 64.3 6.7 No No
10 empty 2.99 54.7 6.5 No No
5TRF_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.14 76.7 18.5 Yes No
2 empty 2.24 61.5 12.7 No No
3 empty 2.01 54.1 13.8 No No
4 empty 2.72 62.8 9.5 No No
5 empty 2.34 60.7 11.9 No No
6 empty 2.12 67.2 8.3 No No
7 empty 2.49 61 11 No No
8 empty 1.85 73.2 7.1 No No
9 empty 2.3 54.5 8.8 No No
10 empty 2.6 68.6 5.9 No No
5LAY_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.71 72.1 15.8 Yes No
2 empty 2.1 59.4 12.3 No No
3 empty 2.26 72.8 7.5 No No
4 empty 2.49 68.4 6.3 No No
5 empty 1.78 62.7 8.3 No No
6 empty 2.52 55.5 11.8 No No
7 empty 2.27 69 8 No No
8 empty 2.66 46.1 8.2 No No
9 empty 2.75 49.3 7.3 No No
10 empty 2.73 63.8 7.2 No No
6Q9H_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 71.6 14.5 Yes No
2 empty 2.21 65.3 13.6 No No
3 empty 2.69 53.9 15 No No
4 empty 1.85 69.8 5.9 No No
5 empty 2.76 54.7 10.7 No No
6 empty 2.54 54.8 10.4 No No
7 empty 2.64 60.8 9.1 No No
8 empty 2.53 60.6 9.1 No No
9 empty 1.96 57.4 9.7 No No
10 empty 2.77 47.5 8 No No
2M86_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.63 75.4 23.4 Yes No
2 empty 2.22 63.8 16.7 No No
3 empty 2.2 72.5 11.7 No No
4 empty 2.38 63.2 11.7 No No
5 empty 2.72 63.8 10.9 No No
6 empty 2.46 54.2 8.4 No No
7 empty 2.05 70.5 8.9 No No
8 empty 2.58 61.6 8 No No
9 empty 2.27 73.1 6.8 No No
10 empty 2.75 53.7 7.9 No No
5J7G_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.69 74.6 16.7 Yes No
2 empty 1.86 63.1 15.3 No No
3 empty 2.43 61.1 6.9 No No
4 empty 2.46 51.7 7.6 No No
5 empty 3.06 55.7 7 No No
6 empty 1.96 52 8 No No
7 empty 2.78 63.2 5.6 No No
8 empty 1.6 65.2 5.3 No No
9 empty 2.8 80.9 0 No No
10 empty 2.18 73.1 5.3 No No
4JVE_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 77.2 18.7 Yes No
2 empty 2.35 62.6 25.5 No No
3 empty 2.21 55.6 14.5 No No
4 empty 2.73 51.6 8.4 No No
5 empty 2.89 62.1 8.5 No No
6 empty 1.69 55.5 8.9 No No
7 empty 2.06 59 7.7 No No
8 empty 2.3 71.1 5.9 No No
9 empty 2.11 61.9 5 No No
10 empty 2.94 77.3 0 No No
4QO4_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 67.6 25.2 Yes No
2 empty 2.06 59.7 12.7 No No
3 empty 2.96 61.2 9.2 No No
4 empty 2.21 61.9 7.5 No No
5 empty 2.57 62.7 8.7 No No
6 empty 3 64.3 8.7 No No
7 empty 1.78 66 8.8 No No
8 empty 1.98 57.9 9 No No
9 empty 2.39 59.8 9.1 No No
10 empty 2.16 67.6 7 No No
4JWR_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 70 18.1 No No
2 empty 2.29 62.9 11.4 No No
3 empty 2.22 64.3 10.3 No No
4 empty 2.65 59.1 12.9 No No
5 empty 1.84 71.2 6.5 No No
6 empty 2.57 66.9 9.8 No No
7 empty 2.19 60.6 10.8 No No
8 empty 2.75 65.1 10.6 No No
9 empty 2.64 54.9 11.6 No No
10 empty 2.01 60 7.2 No No
3LNJ_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.57 65.2 22.1 No No
2 empty 1.86 64 14.5 No No
3 empty 2.29 66 8.1 No No
4 empty 2.78 61.3 9.3 No No
5 empty 2.84 60 9.5 No No
6 empty 2.29 52.8 8 No No
7 empty 1.87 70.7 5.6 No No
8 empty 2.12 70.1 6 No No
9 empty 2.19 63.8 8.7 No No
10 empty 2.97 68.3 5.6 No No
5HMI_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.03 57.1 24.9 Yes No
2 bound 1.78 69.8 20.4 No No
3 empty 2.62 59.5 13.1 No No
4 empty 2.34 64.3 17.2 No No
5 empty 1.94 59.2 11 No No
6 empty 2.57 52.3 9.3 No No
7 empty 1.55 60.9 8.1 No No
8 empty 1.48 74.8 7 No No
9 empty 1.62 55.8 8.4 No No
10 empty 2.47 63.7 6.3 No No
1RV1_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.35 56.4 26.3 Yes No
2 bound 1.56 68.7 16.5 No No
3 empty 2.83 59.4 13.5 No No
4 empty 2.45 58.3 12 No No
5 empty 2.45 50 11.1 No No
6 empty 2.11 57.8 11.4 No No
7 empty 1.97 72.8 6.2 No No
8 empty 2.04 66.9 9.5 No No
9 empty 2.06 61.7 8 No No
10 empty 3.16 70.6 5.9 No No
4QOC_K E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.03 66.7 29.5 Yes No
2 empty 2.16 62.9 11.4 No No
3 empty 2.33 57.4 11.8 No No
4 empty 2.14 67.5 6.9 No No
5 empty 2.29 73.4 5.7 No No
6 empty 2.49 58.6 10.2 No No
7 empty 2.01 66.7 6.9 No No
8 empty 2.8 49.7 9.6 No No
9 empty 2.66 58.4 8.2 No No
10 empty 2.62 55.6 7.7 No No
3LNZ_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 68.3 17.2 No No
2 empty 2.54 64 20.8 No No
3 empty 2.69 58.4 11.4 No No
4 empty 2.34 69.5 7.4 No No
5 empty 2.61 66.3 9.5 No No
6 empty 2.88 60.6 10 No No
7 empty 3.06 63.2 8 No No
8 empty 2.88 54.7 9.9 No No
9 empty 2.71 57.7 8.1 No No
10 empty 2.51 60 5.4 No No
1T4F_M E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 64.9 26 Yes No
2 empty 2.18 59.1 13.4 No No
3 empty 2.45 61.4 11.8 No No
4 empty 2.56 59.2 9.2 No No
5 empty 2.11 57.2 9.2 No No
6 empty 1.51 52.4 7.7 No No
7 empty 2.64 75.4 7.9 No No
8 empty 2.01 76.7 0 No No
9 empty 1.98 64.9 6.2 No No
10 empty 2.66 62.8 5.5 No No
4OGV_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 73.6 15.1 Yes No
2 empty 2.53 59 12.1 No No
3 empty 1.76 66.2 10.7 No No
4 empty 2.68 58.7 13.3 No No
5 empty 1.71 70.8 6.8 No No
6 empty 2.03 68 7.5 No No
7 empty 1.77 56.7 9.9 No No
8 empty 2.21 64.8 7.2 No No
9 empty 1.47 62 6.6 No No
10 empty 2.69 54.8 8.3 No No
3G03_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.84 73 10.7 Yes No
2 empty 2.36 56 10.1 No No
3 empty 2.42 61.6 7.9 No No
4 empty 2.54 66.4 6.4 No No
5 empty 1.96 61.5 6.3 No No
6 empty 2.73 58.9 7.4 No No
7 empty 2.8 63.9 9.8 No No
8 empty 2.91 70.7 5.6 No No
9 empty 2.01 61.8 6.8 No No
10 empty 1.88 65 6.3 No No
5HMI_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.87 68 19.6 No No
2 empty 2.2 67.8 15.3 No No
3 empty 2.23 52.3 12.5 No No
4 empty 2.49 62.2 9.5 No No
5 empty 1.82 66.7 9.3 No No
6 empty 2.58 59.6 11.6 No No
7 empty 2.94 56.7 12.9 No No
8 empty 2.9 60.9 8 No No
9 empty 1.59 57.1 8 No No
10 empty 1.81 69.8 6.2 No No
3VBG_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.41 67.1 23.3 No No
2 empty 2.24 63.2 10.4 No No
3 empty 1.77 55.4 12.4 No No
4 empty 2.4 61.9 12.4 No No
5 empty 2.31 65.6 6.5 No No
6 empty 1.86 63.9 5.9 No No
7 empty 1.75 66.7 7 No No
8 empty 2.4 42.5 8.1 No No
9 empty 1.78 65.7 6.7 No No
10 empty 1.7 47.7 7.5 No No
4MDN_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.51 76.2 18.4 Yes No
2 empty 1.93 59.7 10.4 No No
3 empty 2.54 57.3 13.2 No No
4 empty 2.5 63.3 7.9 No No
5 empty 2.22 68.8 6.7 No No
6 bound 2.38 49.6 8 No No
7 empty 1.92 63.3 8.4 No No
8 empty 2.34 63 8.1 No No
9 empty 2.07 63.4 8.8 No No
10 empty 2.78 65 8.2 No No
4HBM_F E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 77.2 18.1 Yes No
2 empty 2.11 55.1 13.9 No No
3 empty 2.15 61.5 11.4 No No
4 empty 2.69 53.7 8.9 No No
5 empty 1.96 64.3 9.3 No No
6 empty 1.8 50.9 11.6 No No
7 empty 1.63 66.4 9.1 No No
8 empty 1.67 54.3 7.9 No No
9 empty 2.61 53.3 7.7 No No
10 empty 1.77 68 7.9 No No
3W69_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 66.5 20.4 No No
2 empty 2.23 59.2 13.4 No No
3 empty 2.12 64.3 13.5 No No
4 empty 2.52 58.8 10.8 No No
5 empty 2.21 69.3 6.3 No No
6 empty 1.99 53.1 8.3 No No
7 bound 3.17 59.8 8.9 No No
8 empty 2.38 68 8 No No
9 empty 3.36 53.8 6.5 No No
10 empty 3.08 59 6.3 No No
5SWK_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.53 75.3 11.1 Yes No
2 empty 2.49 60.5 11.2 No No
3 bound 2.52 51.6 10.2 No No
4 empty 3.1 71.8 12.3 No No
5 empty 2.53 68 7.2 No No
6 empty 2.09 61.4 7.6 No No
7 empty 2.1 68.6 5.7 No No
8 empty 3.06 69.6 5.7 No No
9 empty 2.89 63.4 5.9 No No
10 empty 2.72 55.6 5.8 No No
5OC8_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 71.5 17.4 Yes No
2 empty 2.29 59.4 22.7 No No
3 empty 2.08 56.5 12.5 No No
4 empty 2.61 53 12.8 No No
5 empty 2.32 65.9 13.2 No No
6 empty 2.55 64.1 7.7 No No
7 empty 2.48 59.9 9.3 No No
8 empty 1.88 64.6 7.8 No No
9 empty 2.07 58.3 10.4 No No
10 empty 2.41 58.4 8.9 No No
3TJ2_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 68.9 31.7 Yes No
2 empty 2.63 62.4 18 No No
3 empty 2.52 49.5 10.1 No No
4 empty 2.57 65.7 9.8 No No
5 empty 1.5 63.8 7.1 No No
6 empty 1.46 61.9 5.8 No No
7 empty 1.79 70.8 6.9 No No
8 empty 3.15 53.3 5.9 No No
9 empty 2.48 52.5 6.2 No No
10 empty 3.09 77.3 0 No No
4HBM_H E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 72.9 18.7 Yes No
2 empty 1.9 62.2 14.9 No No
3 empty 1.43 57.7 12.7 No No
4 empty 2.39 58.8 11.6 No No
5 empty 2.06 59.9 7.9 No No
6 empty 1.87 73.2 6 No No
7 empty 1.96 72 4.6 No No
8 empty 2.03 70.8 6.8 No No
9 empty 2.73 62.6 6.9 No No
10 empty 2.83 60.5 4.8 No No
4OGT_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 74.9 19.3 Yes No
2 empty 2.51 63.1 16.6 No No
3 empty 2.23 62.7 10.6 No No
4 empty 2.78 53 8.7 No No
5 empty 2.34 65.6 7.3 No No
6 empty 1.71 67.1 6.4 No No
7 empty 2.72 67.6 9 No No
8 empty 2.17 58 6.6 No No
9 empty 1.69 64.1 6.2 No No
10 empty 2.65 72 6.7 No No
5TRF_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.38 78.6 15.9 Yes No
2 empty 2.1 64.9 14.4 No No
3 empty 2.36 64.8 11.1 No No
4 bound 2.25 66.7 9.5 No No
5 empty 2.65 58.4 10.9 No No
6 empty 2.09 53.3 8.1 No No
7 empty 3.02 67.6 5.8 No No
8 empty 2.63 67.7 6.7 No No
9 empty 2.24 74.7 0 No No
10 empty 1.22 56.2 5.9 No No
5VK0_Q E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 69.9 21.8 No No
2 empty 1.98 54.2 13 No No
3 empty 2.21 55.6 9.4 No No
4 empty 2.4 65.1 6.3 No No
5 empty 2.28 67.9 7 No No
6 empty 2.83 65.1 7.4 No No
7 empty 3 51.4 7.8 No No
8 empty 2.96 61.9 6.9 No No
9 empty 2.65 56.8 9.6 No No
10 empty 2.18 47.7 6.6 No No
3LNZ_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 66.7 22.3 No No
2 empty 2.22 53.2 10.3 No No
3 empty 2.4 57.6 10.1 No No
4 empty 2.66 56.4 10 No No
5 empty 1.92 69.2 7.2 No No
6 empty 1.94 71.6 5.7 No No
7 empty 2.83 67.7 6.3 No No
8 empty 3.12 68.4 5.6 No No
9 empty 2.68 50 7.5 No No
10 empty 3.04 55.9 7.8 No No
4DIJ_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 70.6 19.7 No No
2 empty 2.08 62.8 11 No No
3 empty 2.19 69.6 7.9 No No
4 empty 2.34 57.4 9.4 No No
5 empty 1.79 64.1 9.7 No No
6 empty 2.72 63.2 6.1 No No
7 empty 2.18 75.8 5.4 No No
8 empty 1.84 49.2 7 No No
9 empty 1.49 59.8 7.4 No No
10 empty 2.13 72.5 0 No No
2AXI_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 63.9 20.9 No No
2 empty 2.5 62.4 11.1 No No
3 bound 2.19 53.8 14.4 No No
4 empty 2.39 52.6 9.2 No No
5 empty 2.21 69.3 8.5 No No
6 empty 1.98 55.3 7.8 No No
7 empty 3.48 68.4 6.8 No No
8 empty 3.11 55.4 6.2 No No
9 empty 2.62 52.6 7.5 No No
10 empty 3.4 41.9 6.5 No No
3IWY_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 64.1 22.4 No No
2 empty 1.85 57.2 17 No No
3 empty 2.21 61.3 15.3 No No
4 empty 2.21 62 9.7 No No
5 empty 2.78 58.5 9.4 No No
6 empty 2.58 53.1 8.4 No No
7 empty 1.94 60.1 9.9 No No
8 empty 2.93 68 8 No No
9 empty 2.46 75.6 5.1 No No
10 empty 2.07 65.5 7.5 No No
3LNJ_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 65.4 24 Yes No
2 empty 2.2 52.5 20.1 No No
3 empty 2.31 67.7 9.4 No No
4 empty 2.35 63.8 8.1 No No
5 empty 2.08 65 7.3 No No
6 empty 2.7 55.4 11.2 No No
7 empty 1.95 57.1 9.8 No No
8 empty 2.43 70.5 6.5 No No
9 empty 1.9 61.3 7.1 No No
10 empty 2.78 69 5.9 No No
5TRF_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 71.4 25.9 Yes No
2 empty 2.21 63.4 11.6 No No
3 empty 2.67 65.8 9.6 No No
4 empty 1.91 66.2 10.7 No No
5 empty 1.89 65.1 10.5 No No
6 empty 2.05 53.8 8.5 No No
7 empty 2.14 62.2 11.4 No No
8 bound 1.87 62.9 10.5 No No
9 empty 2.19 53.3 7.4 No No
10 empty 2.69 65.1 6.4 No No
3LNZ_O E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 67.2 26.6 Yes No
2 empty 2.66 65.9 22.1 No No
3 empty 2.75 61.4 9.4 No No
4 empty 1.81 57.4 11.3 No No
5 empty 3.01 68.3 6.1 No No
6 empty 2.43 68.8 6.5 No No
7 empty 2.8 56.9 7.8 No No
8 empty 1.9 66.7 7.3 No No
9 empty 2.16 57.8 6 No No
10 empty 3.09 66.3 6 No No
4JWR_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.64 71.2 15.5 No No
2 empty 2.27 60.1 11.2 No No
3 empty 2.45 64.7 9 No No
4 empty 2.35 72.1 6.1 No No
5 empty 2.62 56 13.1 No No
6 empty 2.5 66.5 9.9 No No
7 empty 2.03 60.3 9.6 No No
8 empty 2.22 53.3 10.2 No No
9 empty 2.25 64.5 9.9 No No
10 empty 2.78 56.6 8.1 No No
5AFG_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 68.4 19.5 No No
2 empty 2.13 59.3 11.2 No No
3 empty 2.54 60.4 10.2 No No
4 empty 2.61 55.5 8.4 No No
5 empty 1.97 78.3 0 No No
6 empty 1.82 58.7 7.2 No No
7 empty 2.14 55.8 7.9 No No
8 empty 1.63 61.4 6.2 No No
9 empty 2.69 59.6 6.7 No No
10 empty 2.45 57.5 6.5 No No
3TPX_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 65.5 18.6 No No
2 empty 2.36 58.8 20.5 No No
3 empty 2.19 70.8 10.3 No No
4 empty 2.64 62.1 6.6 No No
5 empty 1.9 69 7.3 No No
6 empty 1.79 73.8 7.4 No No
7 empty 2.28 62.4 7.9 No No
8 empty 2.82 69.5 6 No No
9 empty 3.08 63.2 5.8 No No
10 empty 1.98 55.1 6.8 No No
5J7G_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 71.9 18 Yes No
2 empty 2.02 64.2 16.1 No No
3 empty 1.79 60.8 14.5 No No
4 empty 2.06 62.6 13.4 No No
5 empty 2.31 56.9 9.2 No No
6 empty 2.99 69.7 5.5 No No
7 empty 1.73 53.5 7.8 No No
8 empty 1.49 73 5.5 No No
9 empty 3.14 76.7 0 No No
10 empty 2.25 70 0 No No
5HMH_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 69.2 17.7 No No
2 empty 2.4 68.7 14.1 No No
3 empty 2.22 64.1 10.6 No No
4 empty 2.11 55.2 11.9 No No
5 empty 2.38 60.1 9.6 No No
6 empty 1.88 58.4 10.8 No No
7 empty 2.54 57.3 10.5 No No
8 empty 1.81 67.6 8.4 No No
9 empty 1.97 70.1 7.8 No No
10 empty 1.82 71.7 4.9 No No
4JV7_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.55 66.4 18.7 No No
2 empty 2.13 63.1 11.8 No No
3 empty 2.64 54.9 12 No No
4 empty 2.17 67.6 7.4 No No
5 empty 2.19 67.5 6.4 No No
6 empty 2.75 56.6 10.1 No No
7 bound 2.98 62.1 5.8 No No
8 bound 1.53 60 6.3 No No
9 empty 2.33 60.5 6.7 No No
10 empty 3.16 67.5 6.9 No No
5LAY_F E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.92 61.9 32.6 Yes No
2 empty 1.83 79.8 10.2 Yes Yes
3 empty 2.21 77 11.4 No No
4 empty 2.5 59 7.2 No No
5 empty 2.62 69.7 9.5 No No
6 empty 2.02 59.3 8.9 No No
7 empty 3.17 65.5 5.9 No No
8 empty 1.29 71 6.1 No No
9 empty 2.57 64.2 8.4 No No
10 empty 2.31 65.4 7.2 No No
4UD7_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 58.5 40.3 Yes No
2 empty 2.34 57.2 11.9 No No
3 empty 2.48 51.1 12.1 No No
4 empty 2.21 65.9 7.5 No No
5 empty 1.7 65.6 8.9 No No
6 empty 2.09 63.7 8.2 No No
7 empty 2.95 64.1 8 No No
8 empty 2.35 74.4 5.4 No No
9 empty 2.8 65.2 5.9 No No
10 empty 1.72 50.6 6.2 No No
3TJ2_A E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.29 67 34 Yes Yes
2 empty 2.24 60.5 8.2 No No
3 empty 1.87 71.8 6 No No
4 empty 1.43 44.1 6.6 No No
5 empty 3.19 64.9 7 No No
6 empty 2.81 67.9 5.7 No No
7 empty 3.21 73.6 5.7 No No
8 empty 2.44 57.6 4.6 No No
9 empty 2.24 68.5 4.2 No No
10 empty 2.45 56.9 6.2 No No
3EQS_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 67.6 34.5 Yes No
2 empty 2.33 62 15.4 No No
3 empty 2.13 61 10.6 No No
4 empty 2.81 57.8 9.5 No No
5 empty 1.82 57.6 8 No No
6 empty 3.16 65.9 6.2 No No
7 empty 1.9 71.7 5.9 No No
8 empty 2.75 55.6 7.6 No No
9 empty 2.32 61.2 6.3 No No
10 empty 2.21 74.3 0 No No
4JVR_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.65 77.5 13.1 Yes No
2 empty 1.85 48.4 10 No No
3 empty 2.09 60.4 12.2 No No
4 empty 1.77 63.1 9.6 No No
5 empty 2.52 53 11.4 No No
6 empty 2.44 63.3 6.6 No No
7 empty 1.47 62.7 7.7 No No
8 empty 2.45 75.7 6.2 No No
9 empty 2.16 66.4 6.8 No No
10 empty 1.95 61.9 7.8 No No
4HBM_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 76 18.1 Yes No
2 empty 1.84 65.6 11.8 No No
3 empty 1.48 57.6 13 No No
4 empty 1.71 61.6 8.1 No No
5 empty 2.04 60.3 8.1 No No
6 empty 3 56 8.8 No No
7 empty 1.77 69.9 8.8 No No
8 empty 2.55 61.6 6.4 No No
9 empty 2.53 51.7 8.1 No No
10 empty 3.05 62.3 7.2 No No
5J7F_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 73 17.3 Yes No
2 empty 1.68 48.3 9.6 No No
3 empty 2.81 66.2 8.2 No No
4 empty 2.44 71.6 6.9 No No
5 empty 2.04 70.1 5.9 No No
6 empty 2.86 62.8 7.8 No No
7 empty 2.56 58.4 7 No No
8 empty 1.82 65 6.2 No No
9 empty 2.52 67.3 4.6 No No
10 empty 3.17 59.5 6.9 No No
4ZFI_D E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 79.2 14.3 Yes Yes
2 empty 1.79 61.1 11.5 No No
3 empty 2.05 64.6 13.8 No No
4 empty 2.42 57.3 11.9 No No
5 empty 2.21 59.5 7.6 No No
6 empty 2.46 55.8 8.4 No No
7 empty 1.45 51.7 7.8 No No
8 empty .87 60.2 6.8 No No
9 empty 1.7 58.1 7.2 No No
10 empty 2.61 69.9 6.3 No No
3LBK_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 70.7 16.3 No No
2 bound 2.45 49.6 12.4 No No
3 empty 2.48 61.1 9.1 No No
4 empty 2.34 55.6 12.9 No No
5 empty 1.92 65.7 7.7 No No
6 empty 2.09 70.3 7.2 No No
7 empty 1.95 67.1 5.9 No No
8 empty 1.5 71.2 4.8 No No
9 empty 2.79 64.1 6.3 No No
10 empty 2.33 86.2 6.1 Yes No
3VBG_D E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.33 69.9 20.2 No No
2 empty 2.44 67.4 19.7 No No
3 empty 1.74 59.7 11.7 No No
4 empty 2.56 54.9 9.7 No No
5 empty 1.73 60.9 10 No No
6 empty 1.87 60.8 11.2 No No
7 empty 2.2 58.9 7.1 No No
8 empty 2.22 53.4 10 No No
9 empty 1.9 61.1 10.4 No No
10 empty 2.87 68.1 5.1 No No
4JV9_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.52 67.9 16.7 No No
2 empty 2.12 62.2 13.4 No No
3 empty 2.28 69.2 9.4 No No
4 bound 2.82 66.2 8.9 No No
5 empty 1.99 60.7 8.6 No No
6 empty 2.79 50 7.7 No No
7 empty 1.89 66.1 6.6 No No
8 empty 2.79 57.6 9.4 No No
9 bound 1 58.1 5.6 No No
10 empty 2.27 67.9 5.8 No No
4UE1_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.53 68.5 26.8 Yes No
2 empty 2.51 61.8 9.4 No No
3 empty 2.64 54.8 11.9 No No
4 empty 2.62 65.6 10.1 No No
5 empty 2.34 75.6 9.8 No No
6 empty 1.42 63.2 10 No No
7 empty 2.71 56.6 9.2 No No
8 empty 2.9 53.8 9 No No
9 empty 2.37 66.7 8.3 No No
10 empty 2.05 62.3 11.2 No No
4XXB_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.34 54.3 18.9 No No
2 empty 2.46 55.8 12.7 No No
3 empty 2.82 69.1 12.3 No No
4 empty 2.46 68.3 7 No No
5 empty 2.3 60.1 10.5 No No
6 empty 1.56 59.2 7.2 No No
7 empty 3.41 61.8 4.7 No No
8 empty 2.51 100 0 Yes No
9 empty 1.84 72.3 0 No No
3LNJ_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 70 17.1 No No
2 empty 2.49 59.4 13.9 No No
3 empty 1.91 60.5 13.3 No No
4 empty 2.45 67 11.3 No No
5 empty 1.62 59.5 9.5 No No
6 empty 2.7 55.7 10.2 No No
7 empty 1.92 56.5 10.9 No No
8 empty 2.66 60.9 10.1 No No
9 empty 2.49 70.8 7.8 No No
10 empty 2.64 47.1 6.9 No No
4OGN_A E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.53 79.8 14 Yes Yes
2 empty 2.08 62.8 13.9 No No
3 empty 2.41 61.8 8.5 No No
4 empty 2.17 73.2 7.3 No No
5 empty 2.95 63.6 8.8 No No
6 empty 2.16 55.6 8.6 No No
7 empty 2.96 64.8 7 No No
8 empty 2.44 69.6 0 No No
9 empty 2.78 82.3 0 No No
10 empty 1.06 70.9 4.8 No No
4ERF_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.11 68.9 28.8 Yes No
2 empty 2.55 64.5 12.4 No No
3 empty 1.73 64.6 10.6 No No
4 empty 2.5 63.9 9.1 No No
5 empty 2.19 69.8 7.5 No No
6 empty 2.45 55.8 11.1 No No
7 empty 2.33 56.4 11.1 No No
8 empty 2.32 59.2 9.8 No No
9 empty 2.48 68.4 0 No No
10 empty 2.35 49.4 6.4 No No
4ZYF_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 75.7 17 Yes No
2 empty 2.8 64.3 18 No No
3 empty 2.74 55.8 13.9 No No
4 empty 2.69 64.5 11.5 No No
5 empty 2.7 67.9 11.3 No No
6 empty 2.27 66.1 10.2 No No
7 empty 2.16 63.1 8.8 No No
8 empty 2.1 68 6.9 No No
9 empty 2.96 57.5 7.5 No No
10 empty 2.57 61.8 7.2 No No
4WT2_A E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.33 75.3 20.3 Yes Yes
2 empty 2.45 63.8 14.6 No No
3 empty 2.11 61.2 14.8 No No
4 empty 2.03 67.1 9.7 No No
5 empty 2.37 63.4 10.1 No No
6 empty 2.66 64.9 10 No No
7 empty 2.19 54.7 7.5 No No
8 empty 2.14 53.1 6.9 No No
9 empty 2.64 67.3 9.2 No No
10 empty 3.06 58.7 8.1 No No
4OQ3_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.93 69.4 16.3 No No
2 empty 2.47 61 14.6 No No
3 empty 2.64 62.5 10.1 No No
4 empty 1.98 69.9 7.6 No No
5 empty 1.89 57.7 5.6 No No
6 empty 2.52 55.7 7.3 No No
7 empty 2.42 64 5.4 No No
8 empty 1.95 56.6 6.5 No No
9 empty 2.53 68.8 0 No No
10 empty 2.54 70.7 4.8 No No
4ZYI_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 71 28.3 Yes No
2 empty 2.76 60.2 18.1 No No
3 empty 2.41 49.3 14 No No
4 empty 2.31 65.8 12.5 No No
5 empty 2.72 61.3 11.1 No No
6 empty 2.03 58 9.9 No No
7 empty 2.99 55.7 7.5 No No
8 empty 2.82 48.1 6.5 No No
9 empty 2.58 63.3 6.7 No No
10 empty 1.94 65.8 6 No No
5VK0_S E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 69.7 29.1 Yes No
2 empty 2.17 54.1 12.6 No No
3 empty 2.58 63.1 8.5 No No
4 empty 2.37 64.3 7.3 No No
5 empty 2.08 63.9 8 No No
6 empty 3.13 63.2 7.3 No No
7 empty 1.93 68.1 6.9 No No
8 empty 1.93 78.1 4.9 No No
9 empty 2.73 78.2 0 No No
10 empty 2.51 75 5.1 No No
5MNJ_G E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.71 55.4 22.4 No No
2 empty 2.26 59.3 9.7 No No
3 empty 2.48 65.4 12.5 No No
4 empty 2.19 66 10.7 No No
5 empty 1.9 69.3 8.4 No No
6 empty 1.61 53.1 7.5 No No
7 empty 2.1 64.8 6.9 No No
8 empty 2.69 78.9 6 No No
9 empty 3.56 65.6 0 No No
4ODE_A E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.31 77 17.1 Yes Yes
2 empty 2.66 59.9 9.7 No No
3 empty 2.14 62.1 9.8 No No
4 empty 2.72 62.6 10.1 No No
5 empty 2.05 69 9.6 No No
6 empty 2.49 51.6 6.7 No No
7 empty 2.33 77.1 6.2 No No
8 empty 2.49 62.7 8.2 No No
9 empty 2.89 54.4 7.8 No No
10 empty 1.68 67.2 7.4 No No
2HDP_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.77 67.6 21.7 No No
2 empty 2.09 71 14.1 No No
3 empty 2.18 53.8 9.2 No No
4 empty 1.89 67.1 9.9 No No
5 empty 2.11 52.5 9.6 No No
6 empty 2.95 59.4 8.6 No No
7 empty 2.61 68.6 6.6 No No
8 empty 1.74 53.8 5.6 No No
9 empty 1.95 63.1 7.6 No No
10 empty 3.28 58.6 6 No No
3IWY_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.51 63.7 21.2 No No
2 empty 2.18 69.2 14.9 No No
3 empty 2.05 53.2 14.6 No No
4 empty 1.86 66.5 8.3 No No
5 empty 2.58 60 7.5 No No
6 empty 2.08 57.1 10 No No
7 empty 2.83 60.9 7.1 No No
8 empty 2.45 66.7 7.7 No No
9 empty 2.31 67.2 0 No No
10 empty 2.64 52.5 8.4 No No
4ZFI_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 76.5 11.2 Yes No
2 empty 1.92 51.3 12.4 No No
3 empty 2.14 59.2 12.4 No No
4 empty 1.94 64 11.7 No No
5 empty 2.13 69.5 9.2 No No
6 empty 1.9 68.9 9.1 No No
7 empty 1.57 51.4 8.3 No No
8 empty 1.44 65.6 5.5 No No
9 empty 2.27 73.4 4.9 No No
10 empty 2.44 61.2 0 No No
5SWK_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 72.3 15.8 Yes No
2 empty 2.3 59.9 11.3 No No
3 empty 2.74 62.6 11.3 No No
4 empty 1.29 84.4 6.9 Yes No
5 empty 3.06 69.4 5.1 No No
6 empty 1.4 70 7 No No
7 empty 2.68 67.4 3.5 No No
8 empty 2.13 61.6 5.3 No No
9 empty 2.56 61.3 6.9 No No
10 empty 2.28 71.2 5.8 No No
5Z02_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.8 71 18.1 No No
2 empty 2.34 56.2 16.9 No No
3 empty 2.02 55.7 9.9 No No
4 empty 2.8 61.3 13.9 No No
5 empty 2.51 56.5 8.4 No No
6 empty 2.17 70.9 7.3 No No
7 empty 3.01 63.1 6.2 No No
8 empty 1.97 63 7.2 No No
9 empty 2.49 65.7 6.3 No No
10 empty 1.77 49.1 7.5 No No
4QOC_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 67 22.7 No No
2 empty 2.35 58.5 19.8 No No
3 empty 2.22 56.2 10.8 No No
4 empty 2.51 56.8 16.6 No No
5 empty 1.89 70.1 6 No No
6 empty 2.43 53.8 9.6 No No
7 empty 2.01 55.4 9 No No
8 empty 3 62.9 8.8 No No
9 empty 1.8 67.3 5.9 No No
10 empty 1.71 56.2 5.2 No No
6AAW_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.59 66.6 20.3 No No
2 empty 2.26 51.9 11.9 No No
3 empty 2.07 60.4 12.6 No No
4 empty 2.41 54.3 12.5 No No
5 empty 2.46 68.4 10.9 No No
6 empty 1.99 56.1 12 No No
7 empty 1.62 66.7 7.5 No No
8 empty 2.26 61.3 9.5 No No
9 empty 2.81 50.8 7.8 No No
10 empty 2.18 70.7 5.6 No No
4HFZ_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.61 63.1 23.6 No No
2 empty 2.08 48.9 15.7 No No
3 empty 2.53 62.4 14.2 No No
4 empty 2.53 57.9 10.6 No No
5 empty 2.82 53.2 8.8 No No
6 empty 2.35 48.5 11 No No
7 empty 1.89 70.4 5.3 No No
8 empty 2.1 56.5 7.8 No No
9 empty 1.72 65.2 6.1 No No
10 empty 2.82 68.2 4.3 No No
5J7F_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.4 77.6 13.6 Yes No
2 empty 2.01 53.5 10.8 No No
3 empty 2.58 55.6 14.3 No No
4 empty 2.8 73.3 7.9 No No
5 empty 2.27 71.2 8 No No
6 empty 1.44 64.2 7.2 No No
7 empty 2.98 63.3 6.2 No No
8 empty 2.54 76.3 5.8 No No
9 empty 1.96 67 7.8 No No
10 empty 1.26 65.7 5.9 No No
3LNZ_G E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.67 74.6 15.1 Yes No
2 empty 2.74 58 13.5 No No
3 empty 2.39 54.5 13.8 No No
4 empty 2.19 57.7 8.6 No No
5 empty 2.45 56.2 12.2 No No
6 empty 2.15 66.3 9.9 No No
7 empty 2.85 68 6.4 No No
8 empty 2.11 71.1 8.1 No No
9 empty 2.71 47.8 9.3 No No
10 empty 2.18 67.7 6.9 No No
4QOC_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 67.7 17.8 No No
2 empty 2.18 65.4 13.4 No No
3 empty 1.83 69.1 10.2 No No
4 empty 2.89 67.8 11.4 No No
5 empty 2.46 64.9 8.4 No No
6 empty 2.84 63.2 9.8 No No
7 empty 1.96 58.2 11 No No
8 empty 2 68.8 7.5 No No
9 empty 2.68 56.5 7.4 No No
10 empty 2.91 54 5.7 No No
3W69_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.49 67.1 20.5 No No
2 empty 2.12 58.7 24.6 No No
3 empty 2.3 61.9 14.5 No No
4 empty 2.85 55 12.5 No No
5 empty 2.12 62 8.5 No No
6 bound 2.83 58.4 10.7 No No
7 empty 2.19 64.5 8.3 No No
8 empty 2.07 54.8 10.3 No No
9 empty 3.11 60.7 6.7 No No
10 empty 2.02 73.3 4.7 No No
5HMK_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.78 72.5 22.4 Yes No
2 empty 2.68 55.2 12.5 No No
3 empty 2.27 54.8 9.8 No No
4 empty 3 64.6 9.1 No No
5 empty 1.78 60 7.1 No No
6 empty 1.84 72.2 5.5 No No
7 empty 1.85 69.1 6.8 No No
8 empty 2.31 64.8 5.9 No No
9 empty 1.26 69.5 0 No No
10 empty 2.14 46.3 7.8 No No
4ZYC_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 64.2 32.4 Yes No
2 empty 2.44 62.6 12.3 No No
3 empty 2.18 51.6 12 No No
4 empty 2.57 67.4 7.5 No No
5 empty 1.72 62.9 8.5 No No
6 empty 1.85 66.8 8.2 No No
7 empty 1.17 51 6 No No
8 empty 2.3 62.2 6.6 No No
9 empty 2.57 61.1 6.1 No No
10 empty 3.04 56.7 6.7 No No
5TRF_E E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.28 77 15.1 Yes No
2 empty 2.45 57.4 11.7 No No
3 empty 2.82 59.3 12.2 No No
4 empty 2.53 76.8 8.7 No No
5 empty 2.7 70.5 8.8 No No
6 empty 2.96 71.5 8.1 No No
7 empty 1.82 67.7 6.9 No No
8 empty 2.59 75.4 5.3 No No
9 empty 2.29 64.7 8.2 No No
10 empty 1.9 67.9 7.3 No No
4ZGK_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.96 75.6 12.6 Yes No
2 empty 2.65 61.1 21.3 No No
3 empty 1.95 59.4 12.2 No No
4 empty 2.07 60 10.5 No No
5 empty 2.07 66.9 7 No No
6 empty 1.87 55.8 7.6 No No
7 empty 2.15 62.6 6.5 No No
8 empty 2.53 45.9 7.6 No No
9 empty 1.97 72.4 6.7 No No
10 empty 2.76 53.2 5.1 No No
4UE1_D E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 66.7 27.8 Yes No
2 empty 2.55 62.6 15.8 No No
3 empty 1.56 61.4 10.8 No No
4 empty 2.69 62.6 12.1 No No
5 empty 2.64 71.6 8.5 No No
6 empty 2.45 60.4 10.7 No No
7 empty 2.58 61.3 7.5 No No
8 empty 2.7 47.5 8.8 No No
9 empty 2.68 66.2 5.8 No No
10 empty 2.87 81.6 0 No No
3V3B_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.64 69.7 13.4 No No
2 empty 2.37 60.1 13.6 No No
3 empty 2.43 59.9 12.7 No No
4 empty 2.42 60.9 6.8 No No
5 empty 2.85 58.2 6.5 No No
6 empty 2.26 67.3 7.7 No No
7 empty 1.06 60.6 5.3 No No
8 empty 2.29 72.9 5.1 No No
9 empty 2.25 68.4 5.6 No No
10 empty 3.08 65.9 6.1 No No
5VK0_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.69 73.1 16.8 Yes No
2 empty 2.18 57.4 15.9 No No
3 empty 2.19 68.2 11.4 No No
4 empty 2.14 59.1 9.2 No No
5 empty 2.54 49.1 11.1 No No
6 empty 2.45 57.4 10.2 No No
7 empty 2.21 68 7.5 No No
8 empty 1.98 71.1 7.5 No No
9 empty 2.04 50.9 6.6 No No
10 empty 2.49 68.9 5.6 No No
6IM9_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.82 68.2 27.5 Yes No
2 empty 2.34 63.3 11 No No
3 empty 2.2 64.1 9.3 No No
4 empty 2.48 56.2 10.7 No No
5 empty 2.92 67.2 7.5 No No
6 empty 1.39 55.5 7.1 No No
7 empty 2.89 63.8 6.2 No No
8 empty 2.46 74.2 6 No No
9 empty 2.96 68.6 5.9 No No
10 empty 2.69 72.7 5.9 No No
4ZFI_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 74.3 12.1 Yes No
2 empty 2.57 61.9 13.4 No No
3 empty 2.49 55.8 13.2 No No
4 empty 1.82 66 10.7 No No
5 empty 1.93 56.8 12.5 No No
6 empty 2.17 70.8 7.6 No No
7 empty 1.27 67.1 6.5 No No
8 empty 2.24 49.3 8.3 No No
9 empty 1.33 69 6.3 No No
10 empty 1.4 65.8 7.3 No No
3VZV_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 70.2 20.2 No No
2 empty 2.24 57.8 16.3 No No
3 empty 2 67.4 9.9 No No
4 empty 2.32 56.5 10.3 No No
5 empty 2.16 62.8 12.7 No No
6 empty 2.25 50.8 12.3 No No
7 empty 2.12 69.2 6.8 No No
8 empty 1.92 68.1 9.3 No No
9 empty 2.48 74.4 0 No No
10 empty 2.26 57 7.9 No No
5WTS_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.42 70.4 19.3 No No
2 empty 2.14 59 18.4 No No
3 empty 2.46 53.9 10.7 No No
4 empty 2.33 57.3 13.3 No No
5 empty 2.72 58.2 12.1 No No
6 empty 1.87 55.3 11.3 No No
7 empty 2.29 60.5 7.7 No No
8 empty 1.92 59.1 8.4 No No
9 empty 2.39 52.6 6.6 No No
10 empty 2.07 76.4 6.6 No No
3VBG_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 67.9 22.2 No No
2 empty 2.19 55.5 16.8 No No
3 empty 2.37 55.1 12.9 No No
4 empty 2.22 68 9.2 No No
5 empty 1.43 55.4 12.4 No No
6 empty 2.32 60.7 10.3 No No
7 empty 2.7 62.4 9.5 No No
8 empty 2.14 63.4 9.1 No No
9 empty 2.16 66 6.5 No No
10 empty 2.48 62 4.7 No No
5VK0_K E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.85 70.9 16.7 No No
2 empty 2.06 59 13.7 No No
3 empty 3.02 63.7 10.7 No No
4 empty 2.11 58 9.3 No No
5 empty 2.22 64 8.5 No No
6 empty 2.65 75.6 6.4 No No
7 empty 3.47 67.1 7.8 No No
8 empty 2.49 64.9 9.9 No No
9 empty 2.12 60 8.7 No No
10 empty 2.29 68.3 6.5 No No
4OGV_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 72.8 16.2 Yes No
2 empty 2.57 63.3 13 No No
3 empty 1.78 67.1 10.5 No No
4 empty 2.69 58.9 9 No No
5 empty 1.65 69.4 9 No No
6 empty 2.07 62.4 8.5 No No
7 empty 1.74 59.5 10.3 No No
8 empty 2.53 62.8 10.1 No No
9 empty 1.46 61.9 6.5 No No
10 empty 2.28 60.7 7 No No
4OBA_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 73.6 18.9 Yes No
2 empty 2.47 63.2 12.2 No No
3 empty 2.46 59.3 12.5 No No
4 empty 2.83 60.4 14.3 No No
5 empty 1.73 59 9 No No
6 empty 1.99 72.5 6.6 No No
7 empty 2.59 51.6 9.5 No No
8 empty 1.84 70.4 7.3 No No
9 empty 1.96 69.4 6.9 No No
10 empty 1.95 61.3 8.7 No No
4HBM_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 78.5 17.4 Yes No
2 empty 2.36 57.1 19.2 No No
3 empty 2.54 59.4 12.1 No No
4 empty 2.55 55.5 12.1 No No
5 empty 2.24 61.1 8.6 No No
6 empty 2.16 67.3 7.6 No No
7 empty 2.86 97.8 0 Yes No
8 empty 2.06 53.2 8.8 No No
9 empty 1.84 62.9 7.5 No No
10 empty 1.89 63 6.6 No No
4UMN_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.8 71.6 13.8 Yes No
2 empty 2.06 54.4 16.8 No No
3 empty 2.21 57.5 15.5 No No
4 empty 2.49 57.1 10.5 No No
5 empty 2.76 52.6 10.2 No No
6 empty 2.07 47.4 9.9 No No
7 empty 3.19 63.8 9.6 No No
8 empty 1.74 71 8 No No
9 empty 2.66 68.6 8.7 No No
10 empty 2.06 65.1 6.1 No No
4ERE_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 67.9 25.8 Yes No
2 empty 1.74 60.8 14.2 No No
3 empty 2.51 54.5 9.8 No No
4 empty 1.95 53.9 10.7 No No
5 empty 2.33 61.3 8.1 No No
6 empty 1.96 61 7.8 No No
7 empty 2.18 59.6 7.6 No No
8 empty 2.1 69.5 5.2 No No
9 empty 3.2 65 5.8 No No
10 empty 1.64 58.8 5.3 No No
5LAY_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.85 73.1 16.8 Yes No
2 empty 2.02 59.6 12.6 No No
3 empty 2.4 61.3 10.8 No No
4 empty 1.99 74.9 6.4 No No
5 empty 1.45 66 6.2 No No
6 empty 1.75 71.6 7 No No
7 empty 1.53 48 7.4 No No
8 empty 2.54 48.5 6.7 No No
9 empty 2.38 71.6 5.7 No No
10 empty 2.95 67 6.2 No No
4UD7_D E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 69.7 28.9 Yes No
2 empty 2.56 62.5 13.4 No No
3 empty 1.52 60.5 11.4 No No
4 empty 2.56 68.7 9.1 No No
5 empty 1.74 56.7 11.5 No No
6 empty 2.7 63.9 8.3 No No
7 empty 2.91 58.3 6.8 No No
8 empty 2.8 58.2 6.6 No No
9 empty 2.47 74.8 0 No No
10 empty 2.38 52.9 8.1 No No
4ZYC_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.94 69.9 16.9 No No
2 empty 2.28 62.1 13.3 No No
3 empty 2.32 63 15.7 No No
4 bound 2.81 53.1 11 No No
5 empty 2.56 66.3 8.1 No No
6 empty 2.74 51.4 9.2 No No
7 empty 3.4 60.4 8.8 No No
8 empty 3.3 69.6 5.7 No No
9 empty 2.24 71.8 5.4 No No
10 empty 1.48 59.3 7 No No
4UE1_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.39 55.9 24.3 Yes No
2 empty 1.65 61.4 29.2 No No
3 empty 2.37 55 13.3 No No
4 empty 2.84 60 9.3 No No
5 empty 2.59 51.2 11.8 No No
6 empty 1.76 68.1 6.8 No No
7 empty 2.15 64.5 6.9 No No
8 empty 1.74 64.6 9.1 No No
9 empty 2.15 57.4 8.1 No No
10 empty 2.37 70 7 No No
4UD7_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.65 60.8 41.7 Yes No
2 empty 2.32 55.1 12.1 No No
3 empty 2.47 53.2 11.9 No No
4 empty 1.78 77.7 6.9 No No
5 empty 2.3 62.4 8.8 No No
6 empty 1.87 61.8 9.2 No No
7 empty 1.86 68.3 7 No No
8 empty 2.22 63.7 6.3 No No
9 empty 2.96 54.5 9.5 No No
10 empty 1.6 55.4 6.3 No No
5TRF_D E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.57 68.7 28.2 Yes No
2 empty 2.04 65.5 11.7 No No
3 empty 2.76 67.6 10 No No
4 empty 2.08 68.1 7.6 No No
5 empty 1.67 69.3 7.5 No No
6 empty 2.39 59.4 9 No No
7 empty 1.7 54.7 7.6 No No
8 empty 1.94 60.9 7.7 No No
9 empty 3.03 76.8 0 No No
10 empty 2.18 67 6 No No
4DIJ_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 75.4 18.6 Yes No
2 empty 2.06 63.8 10.7 No No
3 empty 1.39 59.5 12.4 No No
4 empty 2.95 66.7 8.8 No No
5 empty 2.07 64.7 7.9 No No
6 empty 1.77 71.8 7.9 No No
7 empty 2.56 59.3 8.1 No No
8 empty 1.8 66.1 7.1 No No
9 empty 2.52 68.9 10.5 No No
10 empty 2.04 60.8 6.9 No No
4OAS_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.61 65.6 22.2 No No
2 empty 2.14 63.9 13.1 No No
3 empty 2.61 60.7 9.6 No No
4 empty 2.42 64.3 9.9 No No
5 empty 2.51 59.4 10 No No
6 empty 1.66 52.6 9.7 No No
7 empty 1.94 61.4 5.8 No No
8 empty 2.23 55.8 9.1 No No
9 empty 2.42 71.5 4.6 No No
10 empty 1.89 63.4 6.3 No No
4QOC_I E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.54 73.4 13.9 Yes No
2 empty 1.83 66.5 13.5 No No
3 empty 2.37 57.7 12.6 No No
4 empty 2.41 60.4 9.8 No No
5 empty 1.83 62.1 9.1 No No
6 empty 2.21 73.9 7.2 No No
7 empty 2.74 63.1 9 No No
8 empty 2.98 52.7 6.5 No No
9 empty 2.08 59.3 7.6 No No
10 empty 2.85 49.1 6.9 No No
4OAS_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 71.8 15.7 Yes No
2 empty 2.41 61.7 13.4 No No
3 empty 2.71 59.6 11 No No
4 empty 2.49 59.1 11.2 No No
5 empty 1.95 69.7 9.3 No No
6 empty 2.37 67.2 8.5 No No
7 empty 2.78 67 8.4 No No
8 empty 2.09 61.5 9.2 No No
9 empty 1.93 60.5 8.7 No No
10 empty 2.09 74.1 6.1 No No
3LBL_C E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.01 63.6 30.9 Yes No
2 empty 2.37 69.2 6.8 No No
3 empty 2 62.5 8.8 No No
4 empty 1.79 66 6.7 No No
5 empty 1.98 61.5 9.6 No No
6 empty 2.46 60.5 6.8 No No
7 empty 2.44 54 7.8 No No
8 bound 2.42 57.9 7 No No
9 empty 2.41 56.3 6.8 No No
10 empty 2.78 66.2 5.6 No No
4ERE_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 67.4 20.7 No No
2 empty 1.76 61.3 12.1 No No
3 empty 2.37 58.2 9.9 No No
4 empty 2.1 61.8 9.8 No No
5 empty 2.35 68.8 6.2 No No
6 empty 2.63 58.8 9.6 No No
7 empty 2.52 68.9 6.7 No No
8 empty 2.21 47.8 8.5 No No
9 empty 2.79 69.7 5.1 No No
10 empty 1.43 70.5 5.4 No No
6Q9O_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.7 72.2 21.3 Yes No
2 bound 2.53 53.1 14.6 No No
3 empty 1.75 64.3 10.4 No No
4 empty 2.67 63.8 8.6 No No
5 empty 1.63 71.4 7.2 No No
6 empty 2.81 53.6 7 No No
7 empty 3.47 63.7 5.9 No No
8 empty 1.79 85.7 0 Yes No
9 empty 2.75 65 6.1 No No
10 empty 3.06 64.9 4.8 No No
5LAW_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.86 72.3 18 Yes No
2 empty 2.2 52.4 13 No No
3 bound 2.51 54.7 16.9 No No
4 empty 2.04 51.3 13.7 No No
5 empty 1.99 58 10.8 No No
6 empty 2.19 69.3 8.7 No No
7 empty 2.53 52.2 10.4 No No
8 empty 1.71 61.2 7.7 No No
9 empty 2.79 58.1 9.1 No No
10 empty 1.94 47.2 6.7 No No
6Q9L_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.58 74.9 13.1 Yes No
2 empty 2.84 59.3 18.4 No No
3 empty 2.13 63.5 10.7 No No
4 empty 2.36 49.5 10.7 No No
5 empty 1.64 68.2 8.3 No No
6 empty 1.99 63.8 8.5 No No
7 empty 2.02 67.5 6.2 No No
8 empty 2.81 71.6 8.5 No No
9 empty 2.41 72.7 5.2 No No
10 empty 2.6 70.7 5.4 No No
6H22_B E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.68 73 18 Yes No
2 empty 2.15 66.3 12.5 No No
3 empty 2.3 62.4 10.8 No No
4 empty 1.6 59.3 7.5 No No
5 empty 2.03 68.9 7.6 No No
6 empty 2.83 57.9 9.6 No No
7 empty 2.76 56.6 9 No No
8 empty 2.06 67.5 5.6 No No
9 empty 2.48 70.1 5.3 No No
10 empty 2.23 61.5 5.7 No No
4ERF_E E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 68.4 16.6 No No
2 empty 2.04 58.6 19.3 No No
3 empty 2.4 64.2 13.1 No No
4 empty 2.76 63.6 10.2 No No
5 empty 2.49 60.4 9.9 No No
6 empty 1.93 58.1 10.6 No No
7 empty 2.38 61.2 5.8 No No
8 empty 1.48 63.9 5.6 No No
9 empty 3.02 48.4 7.8 No No
10 empty 1.8 67.2 6.7 No No
4JWR_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 71.2 12.7 No No
2 empty 2.23 59.1 12.1 No No
3 empty 2.14 63.1 10.1 No No
4 empty 1.8 70 6.8 No No
5 empty 2.35 67.9 11.6 No No
6 empty 2.63 56.6 9.3 No No
7 empty 2.56 54 10.3 No No
8 empty 2.17 65.1 10 No No
9 empty 1.94 62.4 7.3 No No
10 empty 2.87 61.2 8.1 No No
4QOC_G E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.67 71.7 14 Yes No
2 empty 2.71 55 20.2 No No
3 empty 2.08 63.7 12.9 No No
4 empty 2.84 64.1 13.7 No No
5 empty 2.17 54.2 9.8 No No
6 empty 2.02 61.2 10.3 No No
7 empty 1.86 64.1 6.2 No No
8 empty 1.99 62.6 9.8 No No
9 empty 2.06 54.5 10.7 No No
10 empty 2.33 60.5 8.1 No No
4ERF_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 70.9 21.4 No No
2 empty 2.56 56.2 15 No No
3 empty 2.14 64 16.7 No No
4 empty 2.2 67.7 9.3 No No
5 empty 2.5 62.9 10.1 No No
6 empty 2.06 62.1 7.1 No No
7 empty 2.76 67.1 7.2 No No
8 empty 1.66 66.9 9 No No
9 empty 1.86 56.5 9.1 No No
10 empty 2.21 67.3 5.8 No No
5OAI_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.95 68.5 31.2 Yes No
2 empty 1.9 61.6 13.4 No No
3 empty 2.09 62 13.7 No No
4 empty 1.81 64.9 9.6 No No
5 empty 1.64 62 8.1 No No
6 empty 1.82 64.5 6.6 No No
7 empty 3.11 56.5 7.6 No No
8 empty 3.09 62.4 6.3 No No
9 empty 2.42 59.2 6 No No
10 empty 2.57 50.9 6.6 No No
5VK0_W E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.6 70.9 18 No No
2 empty 2.94 61.4 18.1 No No
3 empty 1.82 66.1 14 No No
4 empty 2.67 56.8 11.9 No No
5 empty 2.84 63.2 9.4 No No
6 empty 2.59 70.8 7 No No
7 empty 2.12 57.3 8 No No
8 empty 2.92 64.1 7.2 No No
9 empty 2.44 55.5 9 No No
10 empty 2.29 60 8 No No
6Q96_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.62 69.6 17 No No
2 empty 1.91 71 9.3 No No
3 empty 2.57 55.3 11.1 No No
4 empty 2.5 60 8.8 No No
5 empty 2.02 53.3 12.1 No No
6 empty 3.11 61.3 8.9 No No
7 empty 2.16 57.2 9.6 No No
8 empty 2.01 68.5 6.8 No No
9 empty 1.61 57.8 6.3 No No
10 empty 2.32 60.7 7.4 No No
4ODF_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 76.1 19.1 Yes No
2 empty 1.81 65.1 11.9 No No
3 empty 2.11 58.2 8.6 No No
4 empty 2.68 63.7 11.3 No No
5 empty 2.16 71.9 7.6 No No
6 empty 2.23 60.6 9 No No
7 empty 1.74 67.3 7.9 No No
8 empty 2.6 62.7 6.2 No No
9 empty 2.37 54.6 9.2 No No
10 empty 2.74 62.8 5.9 No No
2LZG_A E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.56 66.9 25 Yes Yes
2 bound 1.26 79.1 18.6 Yes Yes
3 empty 2.22 65.6 20.3 No No
4 empty 2.17 68.3 14.4 No No
5 empty 2.96 74.6 8.1 No No
6 empty 2.99 77 11.8 No No
7 empty 2.17 70.1 10.1 No No
8 empty 2.35 59.8 11.5 No No
9 empty 2.46 55.8 13.3 No No
10 empty 2.73 46.5 12.7 No No
4HBM_G E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.66 79.1 16.1 Yes Yes
2 empty 2.03 68.2 11 No No
3 empty 2.21 51.6 14.2 No No
4 empty 1.92 63.6 10.4 No No
5 empty 1.58 60.2 8.4 No No
6 empty 2.14 62.1 8.3 No No
7 empty 2.43 56 7.5 No No
8 empty 2.13 71.8 7.8 No No
9 empty 2.5 60.3 6.2 No No
10 empty 3.52 58.7 5.8 No No
1T4E_B E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.68 71.2 23.8 No No
2 empty 2.19 58.7 15.1 No No
3 empty 2.18 57.4 11.5 No No
4 empty 2.27 63.4 11.2 No No
5 empty 2.02 62.9 8.8 No No
6 empty 2.29 61.3 11.7 No No
7 empty 2.12 60.2 8.5 No No
8 empty 2.65 72.4 5.5 No No
9 empty 1.96 69 6 No No
10 empty 2.68 51.5 6.3 No No
6H22_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.74 72.8 18.5 Yes No
2 empty 2.27 68 12.6 No No
3 empty 2.46 59.1 10.2 No No
4 empty 2.06 68.8 9.5 No No
5 empty 2.53 51.9 11 No No
6 empty 1.7 72.6 8.6 No No
7 empty 2.84 59.6 10.3 No No
8 empty 3 63.8 8.5 No No
9 empty 2.48 74.4 6.1 No No
10 empty 2.35 53.2 8.3 No No
5UMM_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.76 69.5 19.8 No No
2 empty 2.67 54.9 12.3 No No
3 empty 2.53 59.5 12.2 No No
4 empty 2.18 71.2 8 No No
5 empty 2.08 65.3 7.1 No No
6 empty 3.02 61.4 8.1 No No
7 empty 2.6 68.4 8.3 No No
8 empty 1.89 50.5 6.6 No No
9 empty 1.85 69.4 5.1 No No
10 empty 2.43 65.6 6.8 No No
5VK0_I E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.7 74.8 16 Yes No
2 empty 2.41 61.2 17.2 No No
3 empty 2.4 56.2 12.3 No No
4 empty 3.07 56.8 10.7 No No
5 empty 2.14 53.9 11.7 No No
6 empty 2.63 60.3 9.1 No No
7 empty 2.91 74.4 5.9 No No
8 empty 2.01 66.2 8.4 No No
9 empty 2.85 69.7 5.6 No No
10 empty 2.16 59.9 6.3 No No
5C5A_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.82 65.7 24.9 Yes No
2 empty 2.23 59.2 13.9 No No
3 empty 2.29 66.3 13.6 No No
4 empty 2.15 56.3 11.4 No No
5 empty 1.86 59.1 9.3 No No
6 empty 1.74 59.8 8.4 No No
7 empty 2.27 55.3 9.1 No No
8 empty 3.04 62.9 9.9 No No
9 empty 1.86 55.5 8.2 No No
10 empty 3.03 76.9 0 No No
3TPX_C E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.58 69.3 21.9 No No
2 empty 2.54 57.3 13.4 No No
3 empty 1.89 58.1 15.4 No No
4 empty 2.72 56.2 10.8 No No
5 empty 2.45 67.4 6.7 No No
6 bound 2.19 71.9 6.3 No No
7 bound 1.77 58.3 9 No No
8 empty 2.5 72.8 7.3 No No
9 empty 1.98 64.3 7.3 No No
10 empty 2.33 47.7 5.5 No No
1YCR_A E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.39 74.3 12.7 Yes No
2 empty 2.62 62.7 11.1 No No
3 empty 2.16 55.9 8.7 No No
4 empty 2.05 71.9 7.2 No No
5 empty 1.58 68.3 7.5 No No
6 empty 3.17 61.9 5.7 No No
7 empty 2.26 61 6.1 No No
8 empty 2.18 64.2 7.8 No No
9 empty 1.88 52.2 6.9 No No
10 empty 2.11 54.3 5.4 No No
4HBM_D E3 ubiquitin-protein ligase Mdm2 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 78.2 19.1 Yes No
2 empty 2.23 55.6 14.4 No No
3 empty 1.66 66.5 7.9 No No
4 empty 2.34 70 9.2 No No
5 empty 2.08 61.6 9.3 No No
6 empty 1.32 64.6 7.7 No No
7 empty 2.7 55.9 7.4 No No
8 empty 2.09 65.9 7.1 No No
9 empty 2.77 67.3 7.1 No No
10 empty 3.12 68 5 No No
4OQ3_A E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.9 70.7 16 No No
2 empty 2.34 69.7 8.6 No No
3 empty 2.32 73.9 7.2 No No
4 empty 2.93 51.3 10.8 No No
5 empty 1.85 67.2 7.1 No No
6 empty 2.95 72.1 5.9 No No
7 empty 1.91 51.5 7.3 No No
8 empty 2.88 64.2 6.2 No No
9 empty 2.81 59.8 7.5 No No
10 empty 2.35 75.9 4.9 No No
4OQ3_D E3 ubiquitin-protein ligase Mdm2 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.81 70 15.8 No No
2 empty 2.3 53.7 12.8 No No
3 empty 2.32 55.5 12.7 No No
4 empty 2.25 66.3 10.3 No No
5 empty 1.94 59.1 10.6 No No
6 empty 2.92 65.1 5.9 No No
7 empty 2.1 69.2 6.1 No No
8 empty 2.76 71.8 6 No No
9 empty 2.39 72.5 5.4 No No
10 empty 3.41 77.3 4.9 No No
3TU1_A E3 ubiquitin-protein ligase Mdm2 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.73 69.2 29.3 Yes Yes
2 empty 2.02 67.2 13.1 No No
3 empty 2.55 57.6 13.9 No No
4 empty 1.45 68.8 6.6 No No
5 empty 2.64 59.7 8.1 No No
6 empty 1.74 64.7 7.6 No No
7 empty 2.45 76.7 0 No No
8 empty 2.04 69 6.1 No No
9 empty 3.05 61 6 No No
10 empty 2.88 58.9 0 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed30
Domains assessed as druggable using the strict criteria3
Domains assessed as druggable using the relaxed criteria12

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1RV1_A (4112675) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain (Homo Multimer) 2.3Å Yes Yes
1RV1_A (97901) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 2.3Å Yes No
1RV1_B (97902) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 2.3Å Yes No
1RV1_C (97903) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 2.3Å No No
1RV1_B (4112675) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain (Homo Multimer) 2.3Å Yes Yes
1RV1_C (4112675) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain (Homo Multimer) 2.3Å Yes Yes
1T4E_B (4250263) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain (Homo Multimer) 2.4Å Yes Yes
1T4E_A (4250263) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain (Homo Multimer) 2.4Å Yes Yes
1T4E_B (119143) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 2.4Å No No
1T4E_A (119142) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 2.4Å No No
1T4F_M (119144) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 1.9Å No No
1YCR_A (17420) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 2.6Å Yes No
1Z1M_A (3030325) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED No No
2AXI_A (127494) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 1.4Å No No
2C6A_A (129987) E3 ubiquitin-protein ligase Mdm2 Rubredoxin-like, Ran binding protein zinc finger-like, Ran binding protein zinc finger-like No No
2C6B_A (129988) E3 ubiquitin-protein ligase Mdm2 Rubredoxin-like, Ran binding protein zinc finger-like, Ran binding protein zinc finger-like No No
2GV2_A (135756) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 1.8Å No No
2HDP_A (3100987) E3 ubiquitin-protein ligase Mdm2 UNMATCHED, UNMATCHED, UNMATCHED 2HDP No No
2HDP_B (4082930) E3 ubiquitin-protein ligase Mdm2 UNMATCHED, UNMATCHED, UNMATCHED 2HDP HOMO Yes No
2HDP_A (4082930) E3 ubiquitin-protein ligase Mdm2 UNMATCHED, UNMATCHED, UNMATCHED 2HDP HOMO Yes No
2VJE_A (3220210) E3 ubiquitin-protein ligase Mdm2 UNMATCHED, UNMATCHED, UNMATCHED 2VJE 2.2Å No No
2VJF_A (3220212) E3 ubiquitin-protein ligase Mdm2 UNMATCHED, UNMATCHED, UNMATCHED 2VJF 2.3Å No No
3EQS_A (3390234) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 1.63Å Yes No
3G03_A (3420340) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 1.8Å Yes No
3IUX_A (3480563) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 1.65Å Yes No
3IWY_A (3480660) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 1.93Å No No
3JZK_A (3490488) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 2.1Å Yes No
3JZR_A (3490501) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 2.1Å No No
3JZS_A (3490502) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 1.78Å No No
3LBK_A (3530007) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 2.2Å No No
3LBL_A (3530008) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 1.6Å No No
3LNJ_A (3530591) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 2.4Å Yes No
3LNZ_A (3530615) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, UNMATCHED 1.949Å No No
3TU1_A (4177072) E3 ubiquitin-protein ligase Mdm2 SWIB/MDM2 domain, SWIB/MDM2 domain, SWIB/MDM2 domain 1.6Å Yes Yes
Ligand-based Druggability Score: 0.25
Ligand-based Druggability Score Percentile: 82%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MDM2 is involved in 227 interactions in the network.


Druggability
Overall Druggability Percentile: 74.01
Druggability for Cancer Therapeutics: 98.25
Druggability for Other Therapeutics: 92.42
Cancer-Associated
Cancer-associated percentile : 99.89
Network Articulation Point
Is MDM2 critical for communication in the network?


Detailed Graph Legend:Help