Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MYBPC1 (Q00872) - Overview - Molecular Target Synopsis

Protein


MYBPC1, Myosin-binding protein C, slow-type
UniProt Q00872

Also Known as MYPC1_HUMAN, MYBPC1, MYBPCS

Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Interacts with USP25 (isoform USP25m only); the interaction prevents proteasomal degradation of MYBPC1.

2YUW
SOLUTION STRUCTURE OF 2ND FIBRONECTIN DOMAIN OF SLOW TYPE MYOSIN-BINDING PROTEIN C
RCSB/PDB
Inspect Structure
See all 3D Structures for MYBPC1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: MYBPC1 is active in the following subcellular-locations: cytosol, M band, myofibril, myosin filament, sarcomere, striated muscle thin filament, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MYBPC1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, HL_60

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H446, OCUM-1, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For MYBPC1 there are:
7 structures (7 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis