Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDK17 (Q00537) - Overview - Molecular Target Synopsis

Protein


CDK17, Cyclin-dependent kinase 17
Enzyme Classification 2.7.11.22
UniProt Q00537

Also Known as CDK17_HUMAN, CDK17, PCTAIRE2, PCTK2

May play a role in terminally differentiated neurons. Has a Ser/Thr-phosphorylating activity for histone H1. Found in a complex containing CABLES1, CDK16 and TDRD7. Interacts with TDRD7.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: CDK17 is active in the following subcellular-locations: cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDK17 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TYK-nu, HCC-15, Hs 746T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HUVEC, AG445

(see details)

RNA Interference


CDK17 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: T47D, MFM223. (see details)

3D Structures


At greater than 75% identity similarity to CDK17 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDK17 has been screened with 134 compounds (213 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (16 bioactivities). (see details)