Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDKL1 (Q00532) - Overview - Molecular Target Synopsis

Protein


CDKL1, Cyclin-dependent kinase-like 1
Enzyme Classification 2.7.11.22
UniProt Q00532

Also Known as CDKL1_HUMAN, CDKL1


4AGU
CRYSTAL STRUCTURE OF THE HUMAN CDKL1 KINASE DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for CDKL1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CDKL1 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: CDKL1 is active in the following subcellular-locations: ciliary transition zone, cytoplasm, extracellular exosome, intracellular membrane-bounded organelle, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDKL1 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_62, LOXIMVI, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H209, A-375, SK-N-FI

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

RNA Interference


CDKL1 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: NOS1, H1793. (see details)

3D Structures


For CDKL1 there are:
1 structures (3 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDKL1 has been screened with 220 compounds (229 bioactivities), 4 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)