Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CDK3 (Q00526) - Overview - Molecular Target Synopsis


CDK3, Cyclin-dependent kinase 3
Enzyme Classification
UniProt Q00526

Also Known as CDK3_HUMAN, CDK3, CDKN3

Serine/threonine-protein kinase that plays a critical role in the control of the eukaryotic cell cycle; involved in G0-G1 and G1-S cell cycle transitions. Interacts with CCNC/cyclin-C during interphase. Phosphorylates histone H1, ATF1, RB1 and CABLES1. ATF1 phosphorylation triggers ATF1 transactivation and transcriptional activities, and promotes cell proliferation and transformation. CDK3/cyclin-C mediated RB1 phosphorylation is required for G0-G1 transition. Promotes G1-S transition probably by contributing to the activation of E2F1, E2F2 and E2F3 in a RB1-independent manner. Interacts with CABLES1 and CABLES2 (By similarity). Interacts with ATF1. Binding to CCNC/cyclin-C promotes RB1 phosphorylation.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
305ENSG00000250506ENST00000448471, ENST00000425876ENSP00000400088, ENSP00000410561Q00526-1

Sub-cellular localization

GO terms: CDK3 is active in the following subcellular-locations: nucleus.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CDK3 has gain in 7 cell-lines, loss in 0 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: SK_MEL_5, COLO205, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, GTL-16

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 75% identity similarity to CDK3 there are:
210 structures (250 chains) solved
195 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

CDK3 is solved in complex with the approved drug(s):


(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

CDK3 has been screened with 775 compounds (1405 bioactivities), 93 compounds have bioactivities that show binding affinity of <= 500nM (100 bioactivities). (see details)