Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tmoD (Q00459) - Overview - Molecular Target Synopsis

Protein


tmoD, Toluene-4-monooxygenase system, effector component
UniProt Q00459

Also Known as TMOD_PSEME, tmoD

Effector component of the toluene-4-monooxygenase multicomponent enzyme system which catalyzes the O2- and NADH-dependent hydroxylation of toluene to form p-cresol (PubMed:1885512, PubMed:15240250, PubMed:11297417, PubMed:15882052, PubMed:19033467). Required for optimal efficiency and specificity of the holoenzyme (PubMed:15882052, PubMed:19033467). The alkene monooxygenase multicomponent enzyme system is composed of an electron transfer component and a monooxygenase component interacting with the effector protein TmoD. The electron transfer component is composed of a ferredoxin reductase (TmoF) and a ferredoxin (TmoC), and the monooxygenase component is formed by a heterohexamer (dimer of heterotrimers) of two alpha subunits (TmoA), two beta subunits (TmoE) and two gamma subunits (TmoB).

5TDT
OXYGENATED TOLUENE INTERMEDIATE IN TOLUENE 4-MONOOXYGENASE (T4MOHD) AFTER REACTION IN THE CRYSTAL
RCSB/PDB
Inspect Structure
See all 3D Structures for tmoD

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
103Q00459-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project tmoD has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tmoD there are:
20 structures (27 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis