Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

tmoA (Q00456) - Overview - Molecular Target Synopsis

Protein


tmoA, Toluene-4-monooxygenase system, hydroxylase component subunit alpha
Enzyme Classification 1.14.13.236
UniProt Q00456

Also Known as TMOA_PSEME, tmoA

Component of the toluene-4-monooxygenase multicomponent enzyme system which catalyzes the O2- and NADH-dependent hydroxylation of toluene to form p-cresol (PubMed:1885512, PubMed:15240250, PubMed:2019563, PubMed:19290655, PubMed:19705873). Also able to convert benzene to phenol, catechol, and 1,2,3-trihydroxybenzene by successive hydroxylations (PubMed:15240250). The alkene monooxygenase multicomponent enzyme system is composed of an electron transfer component and a monooxygenase component interacting with the effector protein TmoD. The electron transfer component is composed of a ferredoxin reductase (TmoF) and a ferredoxin (TmoC), and the monooxygenase component is formed by a heterohexamer (dimer of heterotrimers) of two alpha subunits (TmoA), two beta subunits (TmoE) and two gamma subunits (TmoB).

5TDV
INTERMEDIATE O2 DIIRON COMPLEX IN THE Q228A VARIANT OF TOLUENE 4- MOONOXYGENASE (T4MOHD)
RCSB/PDB
Inspect Structure
See all 3D Structures for tmoA

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
500Q00456-1

Gene Copy Number Variation


In COSMIC - Cell Lines Project tmoA has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For tmoA there are:
20 structures (29 chains) solved
10 are solved in complex with at least one small molecule ligand
2 are solved with an approved drug

tmoA is solved in complex with the approved drug(s):

IPH/PHENOL (3Q3O_A),
PAB/AMINOBENZOIC ACID (3Q2A_A).

(see details)
Molecular Target 3D Synopsis