Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CaMKII (Q00168) - Overview - Molecular Target Synopsis

Protein


CaMKII, Calcium/calmodulin-dependent protein kinase type II alpha chain
Enzyme Classification 2.7.11.17
UniProt Q00168

Also Known as KCC2A_DROME, CaMKII, CaM

A key regulator of plasticity in synaptic physiology and behavior, alterations in its activity produce pleiotrophic effects that involve synaptic transmission and development as well as various aspects of behavior. Directly modulates eag potassium channels. Interacts with CASK.

5HU3
DROSOPHILA CAMKII-D136N IN COMPLEX WITH A PHOSPHORYLATED FRAGMENT OF THE EAG POTASSIUM CHANNEL AND MG2+/ADP
RCSB/PDB
Inspect Structure
See all 3D Structures for CaMKII

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
530Q00168-1
516Q00168-2
509Q00168-3
490Q00168-4

Sub-cellular localization


Gene Copy Number Variation


In COSMIC - Cell Lines Project CaMKII has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For CaMKII there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CaMKII has been screened with compounds ( bioactivities). (see details)