Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

aroQ (P9WPX7) - Overview - Molecular Target Synopsis

Protein


aroQ, 3-dehydroquinate dehydratase
Enzyme Classification 4.2.1.10
UniProt P9WPX7

Also Known as AROQ_MYCTU, aroQ, aroD

Catalyzes a trans-dehydration via an enolate intermediate. Homododecamer.

4V0S
CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TYPE II DEHYDROQUINASE D88N MUTANT INHIBITED BY A 3-DEHYDROQUINIC ACID DERIVATIVE
RCSB/PDB
Inspect Structure
See all 3D Structures for aroQ

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization


GO terms: aroQ is active in the following subcellular-locations: cytosol.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project aroQ has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For aroQ there are:
32 structures (217 chains) solved
28 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


aroQ has been screened with 42 compounds (61 bioactivities), 19 compounds have bioactivities that show binding affinity of <= 500nM (21 bioactivities). (see details)